Cyanobacteria in cosmetics: a natural alternative for anti-aging ingredients

Morone, Janaína; Lopes, Graciliana; Oliveira, M. Beatriz P.P.; Vasconcelos, Vítor; Martíns, Rosário

doi:10.1016/b978-0-12-821491-6.00009-0

Cited by 5 publications

(3 citation statements)

References 139 publications

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“…Focusing on skin formulations, cyanobacteria produce a wide array of bioactive metabolites, including phenolic compounds, proteins, pigments, and MMPs inhibitors, that cover the main processes comprising the basis of skin aging, namely antioxidation, photoprotection, and the ability to inhibit crucial enzymes of the ECM [ 8 , 9 , 10 , 11 , 12 ], as recently reviewed [ 1 , 9 ]. Regarding antioxidant activity, numerous strains have been reported to have a representative amount of metabolites with radical scavenging capacity, such as carotenoids, e.g., those from the genera Leptolyngbya , Synechocystis, and Wollea [ 9 , 13 ], phycobiliproteins (PBP), such as Arthospira spp.…”

Section: Introductionmentioning

confidence: 99%

Cyanobacteria Secondary Metabolites as Biotechnological Ingredients in Natural Anti-Aging Cosmetics: Potential to Overcome Hyperpigmentation, Loss of Skin Density and UV Radiation-Deleterious Effects

et al. 2022

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The loss of density and elasticity, the appearance of wrinkles and hyperpigmentation are among the first noticeable signs of skin aging. Beyond UV radiation and oxidative stress, matrix metalloproteinases (MMPs) assume a preponderant role in the process, since their deregulation results in the degradation of most extracellular matrix components. In this survey, four cyanobacteria strains were explored for their capacity to produce secondary metabolites with biotechnological potential for use in anti-aging formulations. Leptolyngbya boryana LEGE 15486 and Cephalothrix lacustris LEGE 15493 from freshwater ecosystems, and Leptolyngbya cf. ectocarpi LEGE 11479 and Nodosilinea nodulosa LEGE 06104 from marine habitats were sequentially extracted with acetone and water, and extracts were analyzed for their toxicity in cell lines with key roles in the skin context (HaCAT, 3T3L1, and hCMEC). The non-toxic extracts were chemically characterized in terms of proteins, carotenoids, phenols, and chlorophyll a, and their anti-aging potential was explored through their ability to scavenge the physiological free radical superoxide anion radical (O2•−), to reduce the activity of the MMPs elastase and hyaluronidase, to inhibit tyrosinase and thus avoid melanin production, and to block UV-B radiation (sun protection factor, SPF). Leptolyngbya species stood out for anti-aging purposes: L. boryana LEGE 15486 presented a remarkable SPF of 19 (at 200 µg/mL), being among the best species regarding O2•− scavenging, (IC50 = 99.50 µg/mL) and also being able to inhibit tyrosinase (IC25 = 784 µg/mL), proving to be promising against UV-induced skin-aging; L. ectocarpi LEGE 11479 was more efficient in inhibiting MMPs (hyaluronidase, IC50 = 863 µg/mL; elastase, IC50 = 391 µg/mL), thus being the choice to retard dermal density loss. Principal component analysis (PCA) of the data allowed the grouping of extracts into three groups, according to their chemical composition; the correlation of carotenoids and chlorophyll a with MMPs activity (p < 0.01), O2•− scavenging with phenolic compounds (p < 0.01), and phycocyanin and allophycocyanin with SPF, pointing to these compounds in particular as responsible for UV-B blockage. This original survey explores, for the first time, the biotechnological potential of these cyanobacteria strains in the field of skin aging, demonstrating the promising, innovative, and multifactorial nature of these microorganisms.

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Section: Introductionmentioning

confidence: 99%

Cyanobacteria Secondary Metabolites as Biotechnological Ingredients in Natural Anti-Aging Cosmetics: Potential to Overcome Hyperpigmentation, Loss of Skin Density and UV Radiation-Deleterious Effects

et al. 2022

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“…For instance, they can be used as photoprotective Mycosporine-like Amino Acids (MAAs) in sunscreens to shield the skin from destructive UVR. In addition, cyanobacteria natural pigments such as phycobiliproteins and carotenoids may be employed as natural colorants as well as antioxidants to shield the skin from destruction resulting from exposure to UV irradiation [123]. Therefore, the field of cyanobacteria exploration is very crucial research.…”

Section: Cyanobacteria In Medical and Pharmaceutical Biotechnologymentioning

confidence: 99%

Versatile Applications of Cyanobacteria in Biotechnology

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Cyanobacteria are blue-green Gram-negative and photosynthetic bacteria which are seen as one of the most morphologically numerous groups of prokaryotes. Because of their ability to fix gaseous nitrogen and carbon dioxide to organic materials, they are known to play important roles in the universal nutrient cycle. Cyanobacteria has emerged as one of the promising resources to combat the issues of global warming, disease outbreaks, nutrition insecurity, energy crises as well as persistent daily human population increases. Cyanobacteria possess significant levels of macro and micronutrient substances which facilitate the versatile popularity to be utilized as human food and protein supplements in many countries such as Asia. Cyanobacteria has been employed as a complementary dietary constituent of feed for poultry and as vitamin and protein supplement in aquatic lives. They are effectively used to deal with numerous tasks in various fields of biotechnology, such as agricultural (including aquaculture), industrial (food and dairy products), environmental (pollution control), biofuel (bioenergy) and pharmaceutical biotechnology (such as antimicrobial, anti-inflammatory, immunosuppressant, anticoagulant and antitumor); recently, the growing interest of applying them as biocatalysts has been observed as well. Cyanobacteria are known to generate a numerous variety of bioactive compounds. However, the versatile potential applications of cyanobacteria in biotechnology could be their significant growth rate and survival in severe environmental conditions due to their distinct and unique metabolic pathways as well as active defensive mechanisms. In this review, we elaborated on the versatile cyanobacteria applications in different areas of biotechnology. We also emphasized the factors that could impede the implementation to cyanobacteria applications in biotechnology and the execution of strategies to enhance their effective applications.

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“…Os filtros orgânicos absorvem os raios UVA e UVB, dissipando sua energia em forma de calor, enquanto os filtros inorgânicos consistem em partículas opacas que refletem e dispersam a radiação ultravioleta e visível. Muitas formulações cosméticas destinadas à fotoproteção combinam os dois tipos de filtros para obter formulações finais foto estáveis e que proporcionem ampla proteção contra radiação (Morone, Janaína et al, 2022). Apesar de indispensáveis, os protetores solares disponíveis no mercado podem, muitas vezes, apresentar efeitos adversos tanto para os seres humanos quanto para os ecossistemas.…”

Section: Cianobactérias Como Fonte Alternativa De Compostos Fotoprote...unclassified

Caracterização e bioprospecção da biomassa de cianobactérias e microalgas presentes em reservatórios de água visando seu potencial biotecnológico

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Em primeiro lugar, gostaria de agradecer as pessoas sem as quais nada disso seria possível: minha mãe e meu irmão. Mãe, muito obrigada por todo apoio e carinho, não só neste período, mas durante toda a vida. Você é e sempre será meu exemplo! Gui, sem você todas as aventuras teriam gosto de medo, e não teriam nem um terço da graça que tiveram. Amo vocês! Também quero estender esse agradecimento a minha linda família: Edinho, Rose, Camila, Alexia e Pedro. Saber que vocês estavam sempre a caminho, seja lá para onde for, fez essa jornada muito mais leve.Quero agradecer também ao Paulo, por ser um incrível companheiro de muitas aventuras e por ter deixado a cidade cinza mais colorida.Aos meus grandes amigos, Andressa, Carol e Marcelo, muito obrigada! Pela companhia, pelas risadas, ombros e cervejas.Não posso deixar de agradecer também a quem participou de toda essa jornada acadêmica comigo. Ao professor Ernani, muito obrigada por ter aberto as portas do doutorado para mim e por todos os ensinamentos durante essa jornada. À professora Camila, que tão gentilmente aceitou me coorientar, me acolheu em seu laboratório e me ensinou tantas coisas, no pessoal e no profissional. Muito obrigada por toda a dedicação e carinho que vi durante esses anos, não só comigo, mas com toda a equipe de trabalho. Você é um exemplo da profissional que quero me tornar.Ao pessoal do LTPNA, Fernanda, Larissa, Mariana, Rafa, Vanessa e, em especial, a Éryka (amiga linda e companheira oficial de revisões e mochilões) e ao Felipe. O apoio de vocês foi essencial. O meu muito obrigada também a todo o pessoal do meu querido LabAzul,

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Cyanobacteria in cosmetics: a natural alternative for anti-aging ingredients

Cited by 5 publications

References 139 publications

Cyanobacteria Secondary Metabolites as Biotechnological Ingredients in Natural Anti-Aging Cosmetics: Potential to Overcome Hyperpigmentation, Loss of Skin Density and UV Radiation-Deleterious Effects

Cyanobacteria Secondary Metabolites as Biotechnological Ingredients in Natural Anti-Aging Cosmetics: Potential to Overcome Hyperpigmentation, Loss of Skin Density and UV Radiation-Deleterious Effects

Versatile Applications of Cyanobacteria in Biotechnology

Caracterização e bioprospecção da biomassa de cianobactérias e microalgas presentes em reservatórios de água visando seu potencial biotecnológico

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