Cyanobacteria and Algae-Derived Bioactive Metabolites as Antiviral Agents: Evidence, Mode of Action, and Scope for Further Expansion; A Comprehensive Review in Light of the SARS-CoV-2 Outbreak

Pradhan, Biswajita; Nayak, Rabindra; Patra, Srimanta; Bhuyan, Prajna Paramita; Dash, Soumya Ranjan; Ki, Jang‐Seu; Adhikary, S. P.; Ragusa, Andrea; Jena, Mrutyunjay

doi:10.3390/antiox11020354

Cited by 33 publications

(15 citation statements)

References 101 publications

(143 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The fresh and marine ecosystems are rich in biodiversity and hold a potential source of sulfated polysaccharides ( Behera et al, 2020 ; Behera et al, 2021 ; Dash et al, 2020 ; Dash et al, 2021 ; Maharana et al, 2019 ; Pradhan, Maharana, Bhakta, & Jena, 2021 ; Pradhan, Patra, Behera, et al, 2020 ; Pradhan, Patra, Dash, et al, 2021 ). Algae-derived sulfated polysaccharides such as fucoidan have potentially been used as an antiviral agent ( Pagarete et al, 2021 ; Pradhan, Bhuyan, et al, 2022 ; Pradhan, Nayak, et al, 2022 ; Pradhan, Patra, Nayak, et al, 2020 ). Many marine algae species contain large amounts of complicated structural sulphated polysaccharides that have been demonstrated to impede enveloped virus replication ( Pereira & Critchley, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

A state-of-the-art review on fucoidan as an antiviral agent to combat viral infections

Pradhan

Nayak

Patra

et al. 2022

Carbohydrate Polymers

Self Cite

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

A state-of-the-art review on fucoidan as an antiviral agent to combat viral infections

Pradhan

Nayak

Patra

et al. 2022

Carbohydrate Polymers

Self Cite

View full text Add to dashboard Cite

“…Carrageenans, ulvans, fucoidans, agars, and alginates have strong antiviral properties [ 124 , 125 ]. It was reported that some of the sulfated polysaccharides could be used to prevent and treat COVID-19 [ 126 , 127 ]. In vitro studies demonstrated that iota-carrageenan can inhibit SARS-CoV-2 [ 128 , 129 ].…”

Section: Macroalgaementioning

confidence: 99%

Algae: Study of Edible and Biologically Active Fractions, Their Properties and Applications

Babich

Сухих

Larina

et al. 2022

Plants

View full text Add to dashboard Cite

The beneficial properties of algae make them perfect functional ingredients for food products. Algae have a high energy value and are a source of biologically active substances, proteins, fats, carbohydrates, vitamins, and macro- and microelements. They are also rich in polyunsaturated fatty acids, proteins, mycosporine-like amino acids, polysaccharides, polyphenols, carotenoids, sterols, steroids, lectins, halogenated compounds, polyketides, alkaloids, and carrageenans. Different extraction parameters are used depending on the purpose and the substances to be isolated. In this study, the following parameters were used: hydromodule 1:10 and an extraction duration of 1–2 h at the extraction temperature of 25–40 °C. A 30–50% solution of ethanol in water was used as an extractant. Algae extracts can be considered as potential natural sources of biologically active compounds with antimicrobial activity and antiviral properties. The content of crude protein, crude fat, and carbohydrates in U. Prolifera, C. racemosa var. peltata (Chlorophyta), S. oligocystum and S. fusiforme (SF-1) was studied. It was found that C. muelleri (Bacillariophyta), I. galbana (Haptophyta), and T. weissflogii (Bacillariophyta) contain about 1.9 times more omega-3 than omega-6 fatty acids. N. gaditana (Ochrophyta), D. salina (Chlorophyta), P. tricornutum (Bacillaryophyta) and I. galbana (Haptophyta) extracts showed inhibitory activity of varying intensities against E. coli or P. aeruginosa. In addition, algae and algae-derived compounds have been proposed to offer attractive possibilities in the food industry, especially in the meat sector, to evolve functional foods with myriad functionalities. Algae can increase the biological activity of food products, while the further study of the structure of compounds found in algae can broaden their future application possibilities.

show abstract

“…One of the most important components of marine ecosystems is phytoplankton [1], and because of their photosynthetic activities, they play an important role as the principal source of biomass and organic molecules in oceans [20,21]. In contrast, many phytoplankton species produce secondary bioactive metabolites, including poisonous toxins [22][23][24][25]. The most hazardous molecular structures of certain toxins derived from marine phytoplankton are displayed in Figure 1.…”

Section: Marine Phytoplankton: the Most Important Source Of Toxinsmentioning

confidence: 99%

Toxic Effects and Tumor Promotion Activity of Marine Phytoplankton Toxins: A Review

Pradhan

Kim

Abassi

et al. 2022

Toxins

Self Cite

View full text Add to dashboard Cite

Phytoplankton are photosynthetic microorganisms in aquatic environments that produce many bioactive substances. However, some of them are toxic to aquatic organisms via filter-feeding and are even poisonous to humans through the food chain. Human poisoning from these substances and their serious long-term consequences have resulted in several health threats, including cancer, skin disorders, and other diseases, which have been frequently documented. Seafood poisoning disorders triggered by phytoplankton toxins include paralytic shellfish poisoning (PSP), neurotoxic shellfish poisoning (NSP), amnesic shellfish poisoning (ASP), diarrheic shellfish poisoning (DSP), ciguatera fish poisoning (CFP), and azaspiracid shellfish poisoning (AZP). Accordingly, identifying harmful shellfish poisoning and toxin-producing species and their detrimental effects is urgently required. Although the harmful effects of these toxins are well documented, their possible modes of action are insufficiently understood in terms of clinical symptoms. In this review, we summarize the current state of knowledge regarding phytoplankton toxins and their detrimental consequences, including tumor-promoting activity. The structure, source, and clinical symptoms caused by these toxins, as well as their molecular mechanisms of action on voltage-gated ion channels, are briefly discussed. Moreover, the possible stress-associated reactive oxygen species (ROS)-related modes of action are summarized. Finally, we describe the toxic effects of phytoplankton toxins and discuss future research in the field of stress-associated ROS-related toxicity. Moreover, these toxins can also be used in different pharmacological prospects and can be established as a potent pharmacophore in the near future.

show abstract

Cyanobacteria and Algae-Derived Bioactive Metabolites as Antiviral Agents: Evidence, Mode of Action, and Scope for Further Expansion; A Comprehensive Review in Light of the SARS-CoV-2 Outbreak

Cited by 33 publications

References 101 publications

A state-of-the-art review on fucoidan as an antiviral agent to combat viral infections

A state-of-the-art review on fucoidan as an antiviral agent to combat viral infections

Algae: Study of Edible and Biologically Active Fractions, Their Properties and Applications

Toxic Effects and Tumor Promotion Activity of Marine Phytoplankton Toxins: A Review

Contact Info

Product

Resources

About