Cyanoacrylic tissue glues: Biochemical properties and their usage in urology

Ayyıldız, Sema Nur; Ayyıldız, Ali

doi:10.5152/tud.2017.09465

Cited by 44 publications

(29 citation statements)

References 48 publications

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“…Moreover, tissue glue has an important haemostatic effect; 29 in haemophilic patients the use of glue reduces the duration of clotting factor replacement after surgery, thus decreasing the high costs of treatment. 30 Finally, bacteriostatic advantage of n-butyl-cyanoacrylate has been already stated in the literature, 31,32 and, to our knowledge, our study confirming the antimicrobical effects of NBCA-MS in a group of pediatric patients undergoing circumcision.…”

Section: Discussionsupporting

confidence: 87%

Pediatric circumcision using n‐butyl‐cyanoacrylate plusMSmonomer: Bacteriostatic and cosmetic advantages over suture

et al. 2020

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Section: Discussionsupporting

confidence: 87%

Pediatric circumcision using n‐butyl‐cyanoacrylate plusMSmonomer: Bacteriostatic and cosmetic advantages over suture

et al. 2020

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“…The use of cyanoacrylate glue has been described in general and laparoscopic surgery. Good results have been obtained in the treatment of acute bleeding of gastric (16) and esophageal varices (17), for the treatment of external pancreatic fistulas (39), and for mesh fixation during laparoscopic inguinal hernioplasty (18). The use of cyanoacrylate has also been evaluated in the prevention of postoperative lymphocele after lymphadenectomy in patients with uterine tumor (15), showing that in the cyanoacrylate group, only 15% of the patients developed lymphocele vs. 36% in the control group.…”

Section: Discussionmentioning

confidence: 99%

“…Interesting results in reducing lymphatic production and seroma development after demolitive and/or conservative breast surgery and after pelvic lymphadenectomy were also obtained using a cyanoacrylatebased synthetic surgical glue (7,15). In particular, recently, the use of a specific type of cyanoacrylate-based synthetic adhesive, Glubran R 2, developed to minimize toxic effect of cyanoacrylate glues, has been described in surgery in substitution or in addition to sutures or staples for its adhesive properties and for the potential activity in decreasing activated partial thromboplastin time, exerting a hemostatic effect and therefore further contributing to tissue adhesion (16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Retrospective Evaluation of the Effectiveness of a Synthetic Glue and a Fibrin-Based Sealant for the Prevention of Seroma Following Axillary Dissection in Breast Cancer Patients

et al. 2020

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Introduction: Seroma formation represents one of the most frequent postoperative complications of axillary dissection in breast cancer (BC) patients. We aimed to retrospectively explore the effectiveness of the intraoperative use of a synthetic cyanoacrylate glue (specifically Glubran®2) vs. the intraoperative use of a fibrin sealant (specifically Tisseel) in reducing seroma formation compared to the use of nonsealant in BC patients who underwent breast surgery and axillary dissection. Materials and Methods: We conducted a retrospective, monocentric observational study on BC patients who underwent axillary dissection associated with breast surgery. The axillary dissection was completed with the application of a closed suction drain and was preceded by the application of either Glubran®2 glue or Tisseel sealant or nonsealant. We analyzed the quantity of serum drained in the first 3 postoperative days, length of hospitalization, days of permanence of axillary drain, seroma development, and presence of postoperative infection signs. Results: Forty-one BC patients were considered. Based on the device used during the surgical treatment, the patients were divided into three groups: group A (17 patients), to whom suction axillary drain was applied; group B (7 patients), to whom Tisseel and axillary suction drain were applied; and group C (17 patients), to whom Glubran®2 and axillary suction drain were applied. Among the three groups, we did not find significant differences in terms of amount of serum drained in the first 3 postoperative days, length of hospitalization, and incidence of seroma. Group C maintained the axillary drain in a significantly lower number of days compared to the other two groups (p = 0.02); it also had a lower incidence of postoperative infections (6%) compared to group A (23%) and group B (57%) (p = 0.02). Conclusions: We did not find any evidence that the use of surgical glues may reduce the formation of seroma following axillary dissection in BC patients. Nevertheless, the use of cyanoacrylate glue in association with closed suction axillary drain seems to contribute to the reduction in days of axillary drain permanence and of postoperative infections, which are known factors delaying the schedule of any adjuvant oncological therapies.

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“…1 Currently, topical tissue adhesives, or "super glues" [e.g., octyl cyanoacrylate (Dermabond®), and n-butyl cyanoacrylate (Histoacryl®)] are widely used in the surgical eld. 2,3 There is a long-chain cyanoacrylic glue that can form a permanent thin lm coating that binds to the keratin in the epidermis, remaining intact for 5-10 days, after which it naturally sloughs off with the epithelia. 4 The advantages of these glues are not only that they can tightly close a surgical wound (as an alternative to sutures or staples), but they also prevent leakage and control bleeding.…”

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confidence: 99%

Effectiveness of Securing Central Venous Catheters with Topical Tissue Adhesive in Patients Undergoing Cardiac Surgery: A Randomized Controlled Pilot Study

Prachanpanich

Morakul

Kiatmongkolkul

2020

Preprint

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Background: Central venous catheters (CVCs) play an important role during cardiac surgery. Topical tissue adhesives form a thin film of coating that becomes bound to the keratin in the epidermis. The advantage of this “super glue” lies in its antimicrobacterial activity. This study aimed to evaluate fixation of CVCs with topical tissue adhesive in patients (prone to bleed) undergoing cardiac surgery, regarding its ability to reduce the incidence of pericatheter leakage.Methods: This randomized controlled trial included 150 patients >15 years of age who were (1) scheduled to undergo elective cardiac surgery, (2) required CVC insertion at the internal jugular vein, and (3) were scheduled for transfer postoperatively to the cardiac intensive care unit. We randomly assigned patients to a topical tissue adhesive group (TA) or a standard control group (SC). The primary outcome was a change of dressing immediately postoperatively due to pericatheter blood oozing. Secondary outcomes were the number of dressings, total dressings per catheter-day, and composite outcome of catheter failure within 3 days. Both intention-to-treat and per-protocol analyses were performed. Seven patients violated the protocol (three TA patients, and four SC patients).Results: Regarding the primary outcome, the SC group had a significantly higher incidence of dressing change immediately postoperatively due to pericatheter leakage than the TA group in both the intention-to-treat analysis (5.33% vs 18.67%, RR 0.25 [95%CI 0.08 to 0.79], P = 0.012) and the per-protocol analysis (5.56% vs 16.90%, RR 0.289 [95%CI 0.09 to 0.95], P = 0.031). There were no significant differences between the two groups for the number of dressings, total dressings per catheter-day, or composite outcome of catheter failure within 3 days. Multiple logistic regression analysis was performed to adjust baseline characteristics which were different in the per-protocol analysis. The result showed that the risk ratios of immediate postoperative dressing change in TA patients were 0.25 compared to the SC group ([95%CI 0.07 to 0.87], P = 0.029) in the per-protocol analysis.Conclusion: Use of a topical tissue adhesive can reduce the incidence of immediate postoperative pericatheter blood oozing.Trial registration: TCTR20180608004, retrospectively registered on June 06, 2018. http://www.clinicaltrials.in.th/index.php?tp=regtrials&menu=trialsearch&smenu=fulltext&task=search&task2=view1&id=3610

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Cyanoacrylic tissue glues: Biochemical properties and their usage in urology

Cited by 44 publications

References 48 publications

Pediatric circumcision using n‐butyl‐cyanoacrylate plusMSmonomer: Bacteriostatic and cosmetic advantages over suture

Pediatric circumcision using n‐butyl‐cyanoacrylate plusMSmonomer: Bacteriostatic and cosmetic advantages over suture

Retrospective Evaluation of the Effectiveness of a Synthetic Glue and a Fibrin-Based Sealant for the Prevention of Seroma Following Axillary Dissection in Breast Cancer Patients

Effectiveness of Securing Central Venous Catheters with Topical Tissue Adhesive in Patients Undergoing Cardiac Surgery: A Randomized Controlled Pilot Study

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