Cyanoacrylate tissue sealant impairs tissue integration of macroporous mesh in experimental hernia repair

Abstract

Mesh fixation by Glubran-II impairs tissue integration, elicits inflammation, and unfavorably alters the biomechanics of macroporous mesh and the abdominal wall.

Randomized clinical trial of tissue glue versus absorbable sutures for mesh fixation in local anaesthetic Lichtenstein hernia repair

“…Those authors used 3/0 polypropylene sutures to fix the mesh. They found no significant difference in morbidity between fibrin glue and cyanoacrylate 27 , but some authors believe that cyanoacrylate glue is potentially cytotoxic in vitro when undiluted, and stiff to handle 28,29 .…”

Recent approaches in designing bioadhesive materials inspired by mussel adhesive protein

“…However, commercially available adhesives are limited by slow degradation rate, toxicity concerns, and poor adhesive strength 230, 231, 232. PEG‐based adhesives are one of the popular synthetic adhesives that have been used for various surgical applications such as dural,233 pulmonary,234 and cardiovascular235 surgeries.…”

A comparison of a bovine albumin/glutaraldehyde glue versus fibrin sealant for hernia mesh fixation in experimental onlay and IPOM repair in rats

“…Several glues have been developed to provide the biomechanical properties required to keep a prosthetic mesh in place until tissue integration is complete [10,12]. Our study group has tested different types of adhesives such as fibrin sealant (FS) and cyanoacrylate glue (CA) [7,[12][13][14]. It was demonstrated that use of CA for mesh fixation was associated with inhibition of tissue integration [12].…”

“…Our study group has tested different types of adhesives such as fibrin sealant (FS) and cyanoacrylate glue (CA) [7,[12][13][14]. It was demonstrated that use of CA for mesh fixation was associated with inhibition of tissue integration [12].…”

“…Substantial effort has been invested in developing new atraumatic methods of mesh fixation such as self-gripping meshes or tissue adhesives [10,11]. Several glues have been developed to provide the biomechanical properties required to keep a prosthetic mesh in place until tissue integration is complete [10,12]. Our study group has tested different types of adhesives such as fibrin sealant (FS) and cyanoacrylate glue (CA) [7,[12][13][14].…”