Cyanoacrylate glue in socket repair: a comparative study

Maia, Gabriela Vasconcelos; Sousa, Carlos Wallyson; Lima, Jose Carlos Rodrigues de; Vecchio, Juliana Lima; Silva, Paulo Goberlânio de Barros; Carvalho, Abrahão Cavalcante Gomes de Souza

doi:10.1016/j.bjoms.2021.01.017

Cited by 4 publications

(11 citation statements)

References 11 publications

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“…17 The recent development of topical cyanoacrylate has gained much attention due to its potential use in surgical wound adhesion and closure. The applications of cyanoacrylates have been expanded and examples of their use are in the ventricular wall, 18 fixations of craniotomy flaps, 11 apicectomy, mucogingival grafting, with better results in the immediate haemostasis, 7 fixations of dental materials to the bone and stabilization of bone grafts. 19 Although clinical and experimental studies have demonstrated the effectiveness of cyanoacrylates in fixing biological tissues, 2,3,12-14 they are histotoxic, as they degenerate in formaldehyde and cyanoacetate, they release heat on polymerization.…”

Section: Discussionmentioning

confidence: 99%

“…The recent development of topical cyanoacrylate has gained much attention due to its potential use in surgical wound adhesion and closure. The applications of cyanoacrylates have been expanded and examples of their use are in the ventricular wall, 18 fixations of craniotomy flaps, 11 apicectomy, mucogingival grafting, with better results in the immediate haemostasis, 7 fixations of dental materials to the bone and stabilization of bone grafts 19 …”

Section: Discussionmentioning

confidence: 99%

“…Tissue adhesives are substances with chemical polymerization properties that can be used in surgical procedures, without hemorrhagic control, and in other wound repair procedures. 7,8 Its biological properties allow it to be used to close soft tissue injuries, as an alternative to suturing in cases with significant flaws and patches of closure. 9,10 An additional advantage is that it does not interfere with computed tomography or magnetic resonance imaging.…”

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confidence: 99%

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Histological analysis of bone grafts fixed with ethyl‐cyanoacrylate and fixed with titanium screw: An experimental study on rats

Chandretti,

Santos,

Júlio

et al. 2024

Oral Surgery

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ObjectivesThe aim of this study was to evaluate, through qualitative and semi‐quantitative histological analysis, onlay autologous bone grafts fixed with ethyl‐cyanoacrylate adhesive and titanium screw, in order to verify whether the method of applying the adhesive would interfere with the graft incorporation.Materials and MethodsFourteen rats underwent bone graft surgery: seven grafts were fixed with ethyl‐cyanoacrylate (SB group, n = 7) and seven grafts were fixed with titanium screws (TS group, n = 7). After 30 days, the grafts were histologically analysed for vitality, adhesive presence, tissue reaction with formation of osteoid matrix, bone resorption presence, capillaries formation, inflammatory infiltrate, fibroblastic proliferation, presence of osteoblasts, osteocytes and osteoclasts. The data were submitted to non‐parametric tests, Mann–Whitney, Fisher's Test, Wilcoxon and McNemar and to statistical analysis (p < 0.05).ResultsNo significant differences were found in the qualitative evaluations. While findings of more osteocytes (p = 0.035) in the TS group in greater inflammation (p = 0.030) and more osteoclasts (p = 0.048) in the SB. Despite the fact that the titanium screw has presented bone neoformation with welding points, there was no complete incorporation and the adhesive affected the bone repair in a way that not even neoformation points could be seen in 30 days.ConclusionThe method of applying the adhesive did not show an advantage according to the histological aspects studied, as there was the formation of a dead space at the interface of the SB group and the adhesive acted as a barrier.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Histological analysis of bone grafts fixed with ethyl‐cyanoacrylate and fixed with titanium screw: An experimental study on rats

Chandretti,

Santos,

Júlio

et al. 2024

Oral Surgery

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“…Tissue adhesives are the subject of numerous scientific research questions [18,19], and are often used for their beneficial hemostyptic effects [14,20,21]. The utilization of various tissue adhesives after tooth extraction is not a new approach [5,14,[22][23][24][25]. For example, fibrin glue [24,25], cyanoacrylates [22,23], and polyvinyl alcohols [5] have been used in extraction sockets with the intention of facilitating surgical procedures [23] and improving the wound healing of bony tissue [5,23,24].…”

Section: Introductionmentioning

confidence: 99%

A Biodegradable Tissue Adhesive for Post-Extraction Alveolar Bone Regeneration under Ongoing Anticoagulation—A Microstructural Volumetric Analysis in a Rodent Model

Heitzer,

Winnand,

Ooms

et al. 2024

IJMS

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In addition to post-extraction bleeding, pronounced alveolar bone resorption is a very common complication after tooth extraction in patients undergoing anticoagulation therapy. The novel, biodegenerative, polyurethane adhesive VIVO has shown a positive effect on soft tissue regeneration and hemostasis. However, the regenerative potential of VIVO in terms of bone regeneration has not yet been explored. The present rodent study compared the post-extraction bone healing of a collagen sponge (COSP) and VIVO in the context of ongoing anticoagulation therapy. According to a split-mouth design, a total of 178 extraction sockets were generated under rivaroxaban treatment, of which 89 extraction sockets were treated with VIVO and 89 with COSP. Post-extraction bone analysis was conducted via in vivo micro-computed tomography (µCT), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX) after 5, 10, and 90 days. During the observation time of 90 days, µCT analysis revealed that VIVO and COSP led to significant increases in both bone volume and bone density (p ≤ 0.001). SEM images of the extraction sockets treated with either VIVO or COSP showed bone regeneration in the form of lamellar bone mass. Ratios of Ca/C and Ca/P observed via EDX indicated newly formed bone matrixes in both treatments after 90 days. There were no statistical differences between treatment with VIVO or COSP. The hemostatic agents VIVO and COSP were both able to prevent pronounced bone loss, and both demonstrated a strong positive influence on the bone regeneration of the alveolar ridge post-extraction.

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“…Cyanoacrylate glue is an acrylic resin that consists of two separate liquids, one for pouring into the mold and another used sparingly as a hardener, but in the case of cyanoacrylate glue, the hardener is water [14,15]. Ifabond Surgical Glue (Peters Surgical, Boulogne-Billancourt, France) is a tissue adhesive made of n-hexyl-cyanoacrylate widely used in general surgery, especially in Cyanoacrylate glue is an acrylic resin that consists of two separate liquids, one for pouring into the mold and another used sparingly as a hardener, but in the case of cyanoacrylate glue, the hardener is water [14,15].…”

Section: Introductionmentioning

confidence: 99%

Surgical Wound Repair with Innovative Hemostatic Glue: Clinical Case Report

et al. 2023

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Background: The labial frenulum may be associated with traction on the marginal gingiva of the incisors with resulting gingival recession, a condition known as “pull syndrome”. In this case, performing a frenulectomy at least 6 months before root covering surgery is necessary. Recently, tissue adhesives have been studied as a good alternative to conventional sutures. Methods: A 34-year-old female affected by pull syndrome of the central lower incisors underwent frenulectomy, and an n-hexyl-cyanoacrylate tissue adhesive was used to ensure wound closure. Results: The patient was instructed in hygiene maneuvers and rinsed with 0.12% chlorhexidine-based mouthwash for 15 days. The glue was partially removed at 7 days, and for the remaining, natural disposal time was expected. The wound healing process was complete after 15 days with minimal postoperative discomfort. Conclusion: This n-hexyl-cyanoacrylate surgical glue could be proposed as a viable alternative to conventional sutures during surgical procedures involving wide flaps with the impossibility of first-intention healing. Moreover, it could be indicated to reduce operative time and patients’ discomfort, even if these hypotheses should be confirmed by future clinical studies.

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Cyanoacrylate glue in socket repair: a comparative study

Cited by 4 publications

References 11 publications

Histological analysis of bone grafts fixed with ethyl‐cyanoacrylate and fixed with titanium screw: An experimental study on rats

Histological analysis of bone grafts fixed with ethyl‐cyanoacrylate and fixed with titanium screw: An experimental study on rats

A Biodegradable Tissue Adhesive for Post-Extraction Alveolar Bone Regeneration under Ongoing Anticoagulation—A Microstructural Volumetric Analysis in a Rodent Model

Surgical Wound Repair with Innovative Hemostatic Glue: Clinical Case Report

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