Cyanoacrylate Adhesives in Surgical Applications

Petrie, Edward M.

doi:10.7569/raa.2014.097306

Cited by 40 publications

(32 citation statements)

References 52 publications

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“…A number of review papers on medical applications of cyanoacrylate adhesives have been published (118)(119)(120). More recently, a review of cyanoacrylate adhesives in surgical applications has been published and which gives an overview of the chemistry and clinical applications of medical-grade cyanoacrylate adhesives over the past 50 years (121).…”

Section: Cyanoacrylates In Medical Applicationsmentioning

confidence: 99%

“…The FDA granted approval of Dermabond for external clinical use in 1998 (124). Other adhesives such as Indermil, Trufill, LiquiBand Optima, Flexifuze, and Surgiseal (Adhezion Biomedical) have all subsequently been granted regulatory approval in many regions around the world for topical wound closure applications (121).…”

Section: Cyanoacrylates In Medical Applicationsmentioning

confidence: 99%

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Polycyanoacrylates

Burns

2016

Encyclopedia of Polymer Science and Technology

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Alkyl 2‐cyanoacrylate monomers are commonly used as instant adhesives or “superglue,” mainly because of their unique ability to undergo rapid polymerization under ambient conditions on a wide range of surfaces. This article overviews the chemistry and physical properties of these materials, the most common methods of preparation, their mode(s) of polymerization, and typical performance properties. The main performance limitations of alkyl 2‐cyanoacrylate adhesives, such as poor hot strength and resistance to extreme environments (high heat and humidity) are explained in terms of the susceptibility of the polymer to degradation, and how the chemical structure of the polymer directly affects this degradation process. An overview is given of how the performance properties of cyanoacrylate adhesives are modified through the inclusion of various thickeners for viscosity modification, accelerators for cure acceleration, and recent advances in two component cyanoacrylate adhesives. The uses of polycyanoacrylates in medical adhesive applications and for the preparation of nanoparticles for drug delivery are briefly reviewed.

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Section: Cyanoacrylates In Medical Applicationsmentioning

confidence: 99%

Section: Cyanoacrylates In Medical Applicationsmentioning

confidence: 99%

Polycyanoacrylates

Burns

2016

Encyclopedia of Polymer Science and Technology

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“…Among fluid adhesives available for medical use, cyanoacrylate glues are extremely adhesive to tissues even in wet conditions. However, when applied as a glue, they show non-elastic adhesion with risk of damage due to traction 20 and its application in intrauterine environment is complex due to its non-solid condition. Previous studies have investigated the use of mussel-like glues as an alternative to cyanoacrylate 15 , since they are based on a catechol side chain of 3,4-dihydroxyphenylalanine (DOPA) amino acid that theoretically secures strong adhesion to almost any surface even underwater 15 , 15 .…”

Section: Discussionmentioning

confidence: 99%

Ex-vivo mechanical sealing properties and toxicity of a bioadhesive patch as sealing system for fetal membrane iatrogenic defects

Helfer

Eixarch

Berdún

et al. 2020

Sci Rep

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Preterm prelabor rupture of membranes (PPROM) is the most frequent complication of fetal surgery. Strategies to seal the membrane defect created by fetoscopy aiming to reduce the occurrence of PPROM have been attempted with little success. The objective of this study was to evaluate the ex-vivo mechanical sealing properties and toxicity of four different bioadhesives integrated in semi-rigid patches for fetal membranes. We performed and ex-vivo study using term human fetal membranes to compare the four integrated patches composed of silicone or silicone-polyurethane combined with dopaminated-hyaluronic acid or hydroxypropyl methylcellulose (HPMC). For mechanical sealing properties, membranes were mounted in a multiaxial inflation device with saline, perforated and sealed with the 4 combinations. We measured bursting pressure and maximum pressure free of leakage (n = 8). For toxicity, an organ culture of membranes sealed with the patches was used to measure pyknotic index (PI) and lactate dehydrogenase (LDH) concentration (n = 5). All bioadhesives achieved appropriate bursting pressures, but only HPMC forms achieved high maximum pressures free of leakage. Concerning toxicity, bioadhesives showed low PI and LDH levels, suggesting no cell toxicity. We conclude that a semi-rigid patch coated with HPMC achieved ex-vivo sealing of iatrogenic defects in fetal membranes with no signs of cell toxicity. These results warrant further research addressing long-term adhesiveness and feasibility as a sealing system for fetoscopy.

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“…Research showed that the longer the hydrocarbon group at the –R position, the slower the rate of polymerization, the less heat released during polymerization, and the lower the histotoxicity. 7 In addition, longer chain esters degrade much slower, allowing more efficient metabolism of the degradation products and reducing the inflammatory response. 8 2-octyl-cyanoacrylate was developed to address toxicity concern and to reduce skin irritation and allergic response, improving properties for medical applications.…”

Section: Discussionmentioning

confidence: 99%

Skin Protectants Made of Curable Polymers: Effect of Application on Local Skin Temperature

Walt

Atwood

Bernatchez

et al. 2017

Advances in Wound Care

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Objective: To measure the skin temperature after application of a new skin protectant intended for incontinence-associated dermatitis (IAD), compared with a commercial product with an analogous cyanoacrylate-based chemistry.Approach: Twelve healthy human volunteers received an application of the new product on one thigh and of the comparator on the other thigh. An infrared camera using ThermaCAM™ software imaged the skin and measured the temperature at the skin surface over time to characterize the thermal cure profile induced by the products on the skin.Results: The new product led to a drop in skin surface temperature (endothermic reaction), whereas the commercial product displayed an exotherm and a slight rise in skin surface temperature.Innovation: Cyanoacrylate-based chemistries come in various formulations, differing in the side chains and additives used. They are liquid monomers that polymerize after application, and this polymerization is accompanied by an exothermic reaction that can be perceived as an unpleasant warming sensation, especially on compromised skin. A new formulation was designed to mitigate this rise in temperature.Conclusion: The new skin protectant may potentially be more comfortable for IAD patients, since it causes a drop in skin surface temperature instead of a rise during the curing process that follows application.

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Cyanoacrylate Adhesives in Surgical Applications

Cited by 40 publications

References 52 publications

Polycyanoacrylates

Polycyanoacrylates

Ex-vivo mechanical sealing properties and toxicity of a bioadhesive patch as sealing system for fetal membrane iatrogenic defects

Skin Protectants Made of Curable Polymers: Effect of Application on Local Skin Temperature

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