Cyanoacrylate Adhesive Provides Efficient Local Drug Delivery

Abstract

Biodegradable drug delivery systems have advanced treatment of a wide spectrum of musculoskeletal problems. However, their lack of availability and cost can restrict use. To find an easily available and inexpensive biodegradable implant, we tested a widely used tissue adhesive, n-butyl-2-cyanoacrylate, as a drug-trapping material. We tested vancomycin with commercially available absorbable gelatin-sponge pieces as the scaffold. We evaluated the in vitro and in vivo drug release profiles and in vivo inflammatory response. A mouse muscle pouch model was used for in vivo evaluations. The released vancomycin level was measured by fluorescence polarization immunoassay technique, and a leukocyte count-based grading system was used to evaluate inflammatory response. Our findings suggest the proposed implant provides effective drug release for as much as 42 days in vitro and 14 days in vivo. The presence of n-butyl-2-cyanoacrylate led to a local inflammatory response which decreased after 3 weeks in the group with less adhesive. These results showed that n-butyl-2-cyanoacrylate could efficiently trap and slowly release a drug when used in the structure of a biodegradable local drug delivery device.

Characterization of Nanoporous Surfaces as Templates for Drug Delivery Devices

“…Poly (2-octyl cyanoacrylate) was used as a the polymer matrix because of its strong adhesive properties, biocompatibility, and as a drug carrier (15)(16)(17). It is also approved by FDA and is being currently used as a tissue adhesive (18).…”

Inkjet printing of bioadhesives

“…Conventional adhesives and techniques suffer from biocompatibility and safety issues. For example, tissue sealants derived from cyanoacrylate esters (Dermabond®, Indermil®, Nexaband®, and Vetbond®) are used in repairing tendon, tooth enamel, cornea, and skin tissues 1–5. Unfortunately, cyanoacrylate adhesives are nonbiodegradable and permanently remain at the treatment site.…”

“…For example, tissue sealants derived from cyanoacrylate esters (Dermabond 1 , Indermil 1 , Nexaband 1 , and Vetbond 1 ) are used in repairing tendon, tooth enamel, cornea, and skin tissues. [1][2][3][4][5] Unfortunately, cyanoacrylate adhesives are nonbiodegradable and permanently remain at the treatment site. As a result, these materials have the potential to induce local inflammation, neovascularization, foreign body reaction, and necrosis.…”

In VitroElution of Amikacin and Ticarcillin from a Resorbable, Self‐Setting, Fiber Reinforced Calcium Phosphate Cement

“…Many bioabsorbable carriers have been investigated including protein materials, bone graft materials and substitutes, and synthetic polymers. Protein materials including collagen sponge, 11,12 fibrinogen, 13 gelatin, 14,15 albumin, ferric‐hyaluronate, 16 R‐gel ™ , 17 and autologous blood clot have all been described but suffer from very short‐term antibiotic release over hours to days 9 . Bone graft materials and substitutes for antibiotic delivery and release include calcium sulfate (plaster of Paris), 18,19 calcium sulfate wrapped in porcine small intestinal submucosa, 20 calcium phosphate cement, 10,21,22 hydroxyapatite cement, 18,23 calcium sulfate and hydroxyapatite combination, 24 bioactive glass, and cancellous bone graft 9 .…”