Cyanidins: metabolism and biological properties

Galvano, Fabio; Fauci, L. La; Lazzarino, Giuseppe; Fogliano, Vincenzo; Ritieni, Alberto; Ciappellano, Salvatore; Battistini, N.; Tavazzi, Barbara; Galvano, G.

doi:10.1016/j.jnutbio.2003.07.004

Cited by 280 publications

(213 citation statements)

References 57 publications

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“…Several flavonoids such as myricetin, pelargonidin and epigallocatechin (EGC) previously identified in epidemiological studies (as being linked to reduced incidence of PCa) 19,[33][34][35][36][37][38] did not display antiproliferative activity in our experiments. These studies, however, were based on retrospective dietary assessments and numerous problems arise while attempting to examine the effect of flavonoids by this methodology.…”

Section: Discussionmentioning

confidence: 48%

Novel antiproliferative flavonoids induce cell cycle arrest in human prostate cancer cell lines

Haddad

Venkateswaran

Viswanathan

et al. 2005

Prostate Cancer Prostatic Dis

147

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Epidemiologic studies have demonstrated an inverse association between flavonoid intake and prostate cancer (PCa) risk. The East Asian diet is very high in flavonoids and, correspondingly, men in China and Japan have the lowest incidence of PCa worldwide. There are thousands of different naturally occurring and synthetic flavonoids. However, only a few have been studied in PCa. Our aim was to identify novel flavonoids with antiproliferative effect in PCa cell lines, as well as determine their effects on cell cycle. We have screened a representative subgroup of 26 flavonoids for antiproliferative effect on the human PCa (LNCaP and PC3), breast cancer (MCF-7), and normal prostate stromal cell lines (PrSC). Using a fluorescence-based cell proliferation assay (Cyquant), we have identified five flavonoids, including the novel compounds 2,2 0 -dihydroxychalcone and fisetin, with antiproliferative and cell cycle arresting properties in human PCa in vitro. Most of the flavonoids tested exerted antiproliferative effect at lower doses in the PCa cell lines compared to the non-PCa cells. Flow cytometry was used as a means to determine the effects on cell cycle. PC3 cells were arrested in G2/M phase by flavonoids. LNCaP cells demonstrated different cell cycle profiles. Further studies are warranted to determine the molecular mechanism of action of 2,2 0 -DHC and fisetin in PCa, and to establish their effectiveness in vivo.

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Section: Discussionmentioning

confidence: 48%

Novel antiproliferative flavonoids induce cell cycle arrest in human prostate cancer cell lines

Haddad

Venkateswaran

Viswanathan

et al. 2005

Prostate Cancer Prostatic Dis

147

View full text Add to dashboard Cite

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“…Rational use of the substances in protection and treatment is possible only if, in addition to studies showing the health-enhancing properties of plant extracts and polyphenolic compounds, we understand the mechanism of their interaction with the living cell, with regard to possible side effects [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Application of the DSC and spectroscopy methods in the analysis of the protective effect of extracts from the blueberry fruit of the genus Vaccinium in relation to the lipid membrane

Pruchnik

Bonarska-Kujawa

Żyłka

et al. 2018

J Therm Anal Calorim

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The aim of the study was to determine changes incurred in lipid model membranes by polyphenol compounds from blueberry fruit of the genus Vaccinium that includes low, high and black blueberry. In particular, the effect of extracts on the packing order in the lipid hydrophilic phase, the fluidity of the hydrophobic phase, as well as the temperature of the phase transition in phospholipids was studied. Model membranes were formed of dipalmitoylphosphatidylcholine (DPPC) and egg phosphatidylcholine. The interaction of extracts with lipids was studied using the differential scanning calorimetry, infrared spectroscopy (ATR-FTIR) and fluorimetry using Laurdan, Prodan and DPH probes. All experimental results indicate that the biggest changes are in the hydrophilic part of the lipid bilayer. The polyphenol compounds had practically no influence on fluidity in the hydrophobic region of the membranes. No changes in the temperature of the main phase transition of DPPC were observed and only a small change in the temperature of pretransition for high concentration of compounds. Results obtained with the ATR-FTIR method did not reveal any changes in the alkyl chain region of bilayer; however, a small shift of bands was observed for phosphate and choline groups-the broadest effect appeared for the wild bilberry. The findings indicate that polyphenolic compounds contained in extracts of blueberries interact with the membrane surface and therefore can protect it.

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“…Anthocyanins are polyphenol pigments in plants (Galvano et al, 2004;Williams and Grayer, 2004). Anthocyanins and their aglycons, anthocyanidins, have various biological effects, such as antioxidative activity (Cao et al, 1997;Kahkonen and Heinonen, 2003;Rahman et al, 2006;Tsuda et al, 1999a), anti-hyperglycemic activity (Matsui et al, 2002), anti-inflammatory activity (Karlsen et al, 2007;Wang et al, 2008b), cell protective activity (Elisia and Kitts, 2008;Tarozzi et al, 2007) and antitumor activity (Hou, 2003;Lala et al, 2006;Kang et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Differential Effects of Cyanidin and Cyanidin-3-glucoside on Human Cell Lines

Takeuchi

Ohtani

et al. 2011

FSTR

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Anthocyanins are pigments in plants. Anthocyanins and their aglycons, anthocyanidins, have various biological effects. In the present study, we examined the effects of cyanidin and cyanidin-3-glucoside on intracellular reactive oxygen species (ROS) levels and on proliferative effects, using four cancer cell lines and one normal cell line, and we found that cyanidin (100 μmol/L) has significant effects when compared with cyanidin-3-glucoside. Cyanidin reduced intracellular ROS levels in MCF-7, HuH-7, HepG2, Caco-2 and HUVEC cell lines, but cyanidin-3-glucoside did not. Cyanidin inhibited the proliferation of MCF-7, HuH-7, HepG2 and Caco-2 cells, but cyanidin-3-glucoside did not. Cyanidin and cyanidin-3-glucoside had no effect on the proliferation of HUVEC. We also tested cyanidin-3-rutinoside, peonidin and peonidin-3-glucoside, but the presence of a sugar in their structure hampered the biological effects of aglycons. These results suggest that a sugar in the anthocyanin structure affects biological activity.

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Cyanidins: metabolism and biological properties

Cited by 280 publications

References 57 publications

Novel antiproliferative flavonoids induce cell cycle arrest in human prostate cancer cell lines

Novel antiproliferative flavonoids induce cell cycle arrest in human prostate cancer cell lines

Application of the DSC and spectroscopy methods in the analysis of the protective effect of extracts from the blueberry fruit of the genus Vaccinium in relation to the lipid membrane

Differential Effects of Cyanidin and Cyanidin-3-glucoside on Human Cell Lines

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