Cyanidin-3-O-glucoside restores spermatogenic dysfunction in cadmium-exposed pubertal mice via histone ubiquitination and mitigating oxidative damage

Liu, Xusheng; Yao, Zilan; Yang, Duomeng; Jiang, Xinwei; Sun, Jianxia; Tian, Lingmin; Hu, Jun; Wu, Biyu; Bai, Weibin

doi:10.1016/j.jhazmat.2019.121706

Cited by 62 publications

(44 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The antioxidant effects of C3G can be used to treat diseases, and it was reported that C3G modulated oxidation dependent on iron [ 14 ]. C3G ameliorated ferroptosis via histone ubiquitination and oxidative mitigation [ 15 ]. These literatures indicated that C3G might exhibit its pharmacological effect through ferroptosis and ubiquitination modification.…”

Section: Discussionmentioning

confidence: 99%

The Protective Effect of Cyanidin‐3‐Glucoside on Myocardial Ischemia‐Reperfusion Injury through Ferroptosis

Shan

Yin

et al. 2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

This study was conducted to estimate the protective effect of Cyanidin-3-glucoside (C3G) on myocardial ischemia-reperfusion (IR) injury and to explore its mechanism. The rats were subjected to left anterior descending ligation and perfusion surgery. In vitro experiments were performed on H9c2 cells using the oxygen-glucose deprivation/reoxygenation (OGD/R) model. The results showed the administration of C3G reduced the infarction area, mitigated pathological alterations, inhibited ST segment elevation, and attenuated oxidative stress and ferroptosis-related protein expression. C3G also suppressed the expressions of USP19, Beclin1, NCOA4, and LC3II/LC3I. In addition, treatment with C3G relieved oxidative stress, downregulated LC3II/LC3I, reduced autophagosome number, downregulated TfR1 expression, and upregulated the expressions of FTH1 and GPX4 in OGD/R-induced H9c2 cells. C3G could inhibit the protein levels of USP19 and LC3II. C3G promoted K11-linked ubiquitination of Beclin1. Further evidence that C3G reduced ferroptosis and ameliorated myocardial I/R injury was demonstrated with the ferroptosis promoter RSL3. Taken together, C3G could be a potential agent to protect myocardium from myocardial I/R injury.

show abstract

Section: Discussionmentioning

confidence: 99%

The Protective Effect of Cyanidin‐3‐Glucoside on Myocardial Ischemia‐Reperfusion Injury through Ferroptosis

Shan

Yin

et al. 2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…As a result of experimental studies, it has been reported that cadmium causes changes in reproductive hormone levels, disrupts spermatogenesis, causes DNA damage, induces apoptosis. 6,10,11 In many studies, it has been reported that oxidative stress is induced in almost all organs of the body in acute or chronic cadmium exposure. In these studies in the literature list, we have learned that cadmium causes decreased levels of the indicator related to testicular oxidation in the testicular tissue.…”

Section: Discussionmentioning

confidence: 99%

“…1 Cadmium, a heavy metal, has been reported to be abundant especially in industrial areas, 2 causing injury in the liver, kidneys and testicles. [3][4][5][6][7][8][9] Especially, in the toxicity it causes in the testicles, it has been reported that spermatogenesis is impaired and there are decreases in gonadotropic hormones and testosterone hormone. [10][11][12] It has also been reported to cause apoptosis in the male reproductive cell.…”

Section: Introductionmentioning

confidence: 99%

“…[10][11][12] It has also been reported to cause apoptosis in the male reproductive cell. 6 There are many studies in which oxidant / antioxidant balance is troubled after cadmium exposure. [3][4][5][6]8,9 Boron is an essential nutrient in animals as much as necessary for the normal growth and development of plants.…”

Section: Introductionmentioning

confidence: 99%

“…6 There are many studies in which oxidant / antioxidant balance is troubled after cadmium exposure. [3][4][5][6]8,9 Boron is an essential nutrient in animals as much as necessary for the normal growth and development of plants. 13,14 It is emphasized that some fruits (Banana, apple, grape, peanut, hazelnut) and vegetables (carrot, potato, bean, broccoli, cabbage) have rich boron content.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Investigation of the Effects of Calcium Fructoborate on Testicular Structure in Rats within the Framework of Biochemical Parameters, Testosterone Hormone and DNA Damage in Cadmium Chloride Induced Toxicity

Belhan¹,

Kömüroğlu²,

Özdek³

et al. 2021

IJPER

View full text Add to dashboard Cite

Background: The present study aims to investigate the effects of calcium fructoborate on testicular DNA damage and testicular tissue biochemical markers and serum testosterone levels after cadmium chloride administration. Materials and Methods: 28 Wistar albino rats (200-220 g) in the study were divided into 4 groups with an equal number. These groups are; Control group (No chemicals applied), calcium fructoborate (100 mg) group, Cadmium chloride (200 mg/L) + calcium fructoborate (100 mg), Cadmium chloride (200 mg/L) group. The study lasted 28 days and both chemicals were applied daily with oral gavage. Results: While 8-hydroxy-2-deoxyguanosine (8-OHdG) expression was moderate in the cadmium chloride + calcium fructoborate group, the expression in the cadmium chloride group was severe. In the cadmium chloride group, testicular tissue glutathione (GSH) and 8-OHdG levels, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and serum testosterone levels were significantly decreased compared to other groups. It is determined that the reversal of the change in the parameters listed in the calcium fructoborate group. Conclusion: The reversal of the change in the parameters listed in the calcium fructoborate group indicates the positive strength of the present chemical. It is our suggestion to transfer calcium fructoborate into life practice by conducting further clinical studies and evaluating different parameters.

show abstract

Protective effects of cyanidin‐3‐O‐glucoside on UVB‐induced chronic skin photodamage in mice via alleviating oxidative damage and anti‐inflammation

Peng

Liu

et al. 2020

Food Frontiers

Self Cite

View full text Add to dashboard Cite

Excessive ultraviolet (UV) radiation exposure results in skin chronic photodamage via stimulating reactive oxygen species (ROS) and inflammation. Anthocyanins are a group of flavonoids frequently found in edible plants. Cyanidin-3-O-glucoside (C3G) as a typical anthocyanin shows effective anti-oxidative and anti-inflammatory properties. This study aims to investigate whether the topical application of C3G moisturizing gel on mice can protect the skin from UVB-induced chronic photodamage. The results of in vitro experiment showed that the active ingredient C3G can penetrate the mice skin. The dorsal of Kunming mice were treated with C3G moisturizing gel (100, 200, 300 μmol/L) after UVB exposure. The animal experiment demonstrated that C3G can reduce chronic photodamage caused by UVB. C3G could effectively ameliorate the UVB-induced epidermal barrier dysfunction including an increase in the skin hydration and decrease in the transepidermal water loss, and have statistically significance. Besides, our results also indicated that C3G inhibited UVB-induced epidermal hyperplasia, the destruction of collagen fibers, ROS levels, and the expression of COX-2 and IL-6. In brief, these results indicate that C3G can reduce UVB-induced chronic photodamage by inhibiting oxidative stress and inflammation.

show abstract

Cyanidin-3-O-glucoside restores spermatogenic dysfunction in cadmium-exposed pubertal mice via histone ubiquitination and mitigating oxidative damage

Cited by 62 publications

References 43 publications

The Protective Effect of Cyanidin‐3‐Glucoside on Myocardial Ischemia‐Reperfusion Injury through Ferroptosis

The Protective Effect of Cyanidin‐3‐Glucoside on Myocardial Ischemia‐Reperfusion Injury through Ferroptosis

Investigation of the Effects of Calcium Fructoborate on Testicular Structure in Rats within the Framework of Biochemical Parameters, Testosterone Hormone and DNA Damage in Cadmium Chloride Induced Toxicity

Protective effects of cyanidin‐3‐O‐glucoside on UVB‐induced chronic skin photodamage in mice via alleviating oxidative damage and anti‐inflammation

Contact Info

Product

Resources

About