Cyanidin-3-<i>O</i>-β-glucoside Purified from Black Rice Protects Mice against Hepatic Fibrosis Induced by Carbon Tetrachloride via Inhibiting Hepatic Stellate Cell Activation

Jiang, Xinwei; Guo, Honghui; Shen, Tao; Tang, Xilan; Yang, Yan; Ling, Wenhua

doi:10.1021/acs.jafc.5b02181

Cited by 44 publications

(29 citation statements)

References 48 publications

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“…Extraction and purification of Cy-3-g from black rice was performed as described previously (16). Briefly, highly purified Cy-3-g was isolated from black rice using middle-pressure liquid chromatography (MPLC).…”

Section: Methodsmentioning

confidence: 99%

Anthocyanin Cyanidin-3-Glucoside Attenuates Platelet Granule Release in Mice Fed High-Fat Diets

ZHOU

Deng

Chen

et al. 2017

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Summary Platelet granule release is considered an important target for preventing and treating cardiovascular diseases (CVDs). Cyanidin-3-glucoside (Cy-3-g) is a predominant bioactive anthocyanin compound in many edible plants and has been reported to be protective against CVDs by attenuating platelet dysfunction. However, direct evidence of the action of Cy-3-g on platelet granule secretion in purified platelets from in vivo assays is still poor. In the present study, we demonstrated that dietary supplementation of purified Cy-3-g reduces serum lipid levels and facilitates down-regulation of the platelet granule release of substances such as P-selectin, CD40L, 5-HT, RANTES and TGF-b1 in gel-filtered platelets, in addition to attenuating serum PF4 and b-TG levels in mice fed high-fat diets. These results provide evidence that Cy-3-g protects against thrombosis and CVDs by inhibiting purified platelet granule release in vivo.

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Section: Methodsmentioning

confidence: 99%

Anthocyanin Cyanidin-3-Glucoside Attenuates Platelet Granule Release in Mice Fed High-Fat Diets

ZHOU

Deng

Chen

et al. 2017

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Other natural anti-adipogenic substances, like cyanidin and carvacrol, Pompei et al (2012) and Spalletta et al (2018) may also restrain adipose tissue fibrosis, as recently seen for liver fibrosis. In particular cyanidin has been proven to be effective in antagonizing the oxidative stress, the inflammatory response and HSC activation; while carvacrol has been found to be particularly successful in inhibiting the TGFβ signaling pathway, by downregulating not only the TGF-β levels but also the protein levels of the related Hippo cascade mediators such as TAZ and YAP (Cho et al, 2014;Jiang et al, 2015;Hussein et al, 2017;Mohseni et al, 2019). Blockade of these signaling pathways could inhibit EMT and ameliorate fat fibrosis, as well as the associated metabolic dysfunctions such as insulin resistance.…”

Section: Adipose Tissue Fibrosismentioning

confidence: 99%

The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders

Gregorio

Robuffo

Spalletta³

et al. 2020

Front. Cell Dev. Biol.

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Fibrosis is a chronic and progressive disorder characterized by excessive deposition of extracellular matrix, which leads to scarring and loss of function of the affected organ or tissue. Indeed, the fibrotic process affects a variety of organs and tissues, with specific molecular background. However, two common hallmarks are shared: the crucial role of the transforming growth factor-beta (TGF-β) and the involvement of the inflammation process, that is essential for initiating the fibrotic degeneration. TGF-β in particular but also other cytokines regulate the most common molecular mechanism at the basis of fibrosis, the Epithelial-to-Mesenchymal Transition (EMT). EMT has been extensively studied, but not yet fully explored as a possible therapeutic target for fibrosis. A deeper understanding of the crosstalk between fibrosis and EMT may represent an opportunity for the development of a broadly effective anti-fibrotic therapy. Here we report the evidences of the relationship between EMT and multi-organ fibrosis, and the possible therapeutic approaches that may be developed by exploiting this relationship.

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“…A series of studies from Ling's team suggested that 800 mg/kg dietary cyanidin-3-O- β -glucoside alleviated liver fibrosis by suppressing inflammatory factors, such as TNF- α , IL-6, and IL-10. The progression of HSC activation was also blocked by cyanidin-3-O- β -glucoside through significant inhibition of HSC proliferation and migration [ 111 , 112 ].…”

Section: Flavonoidsmentioning

confidence: 99%

A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids

Pan

Jiang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Liver fibrosis resulting from continuous long-term hepatic damage represents a heavy burden worldwide. Liver fibrosis is recognized as a complicated pathogenic mechanism with extracellular matrix (ECM) accumulation and hepatic stellate cell (HSC) activation. A series of drugs demonstrate significant antifibrotic activity in vitro and in vivo. No specific agents with ideally clinical efficacy for liver fibrosis treatment have been developed. In this review, we summarized the antifibrotic effects and molecular mechanisms of 29 kinds of common natural products. The mechanism of these compounds is correlated with anti-inflammatory, antiapoptotic, and antifibrotic activities. Moreover, parenchymal hepatic cell survival, HSC deactivation, and ECM degradation by interfering with multiple targets and signaling pathways are also involved in the antifibrotic effects of these compounds. However, there remain two bottlenecks for clinical breakthroughs. The low bioavailability of natural products should be improved, and the combined application of two or more compounds should be investigated for more prominent pharmacological effects. In summary, exploration on natural products against liver fibrosis is becoming increasingly extensive. Therefore, natural products are potential resources for the development of agents to treat liver fibrosis.

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Cyanidin-3-O-β-glucoside Purified from Black Rice Protects Mice against Hepatic Fibrosis Induced by Carbon Tetrachloride via Inhibiting Hepatic Stellate Cell Activation

Cited by 44 publications

References 48 publications

Anthocyanin Cyanidin-3-Glucoside Attenuates Platelet Granule Release in Mice Fed High-Fat Diets

Anthocyanin Cyanidin-3-Glucoside Attenuates Platelet Granule Release in Mice Fed High-Fat Diets

The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders

A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids

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