“…[22][23][24][25][26] Additionally, within these systems, the incorporation of water-based and organicbased polymers, 25,[27][28][29] functional polymers for the creation of specific targeting and stealth patches on the surface of the particles, 30,31 stimuliresponsive polymers for on-demand therapeutic release kinetics, [32][33][34] small molecule-based therapeutics, [33][34][35] DNA-based therapeutics, 36 protein-based therapeutics, 35 and imaging agents 22 have been explored. Furthermore, the interaction of such systems with various cell types, 34,[36][37][38][39][40][41] their biodistribution in vivo, 42 and their functionality as carriers for dual therapeutic delivery to the cochlea 35,43 have demonstrated that multifunctional systems fabricated based on EHD co-jetting can be ideal carriers for targeted delivery in various applications. To date, the majority of these studies have been accomplished using microparticles, and while some have contained nanoparticles, 36,37,42 a systematic study into the fabrication of uniform, multifunctional nanoparticles using the EHD co-jetting system has not been reported.…”