CXCR4-dependent ‘wandering period’ of migrating cortical interneurons

Neuronal Migration on Silicon Microcone Arrays with Different Pitches

“…The soma then migrated to the direction of the remaining extended branch, which was consistent with the previous in vitro studies, employing flat substrates, as well as in vivo ones. [57][58][59] These representative examples showed that the neurons on the microtopographical substrate, in some cases, exhibited the migration behaviors found in the neurons both on flat substrates andin vivo. In addition, the two types of neurons in Figure 3a,b showed the nonsaltatory continuous and conventional saltatory movements respectively (Figure S5, Supporting Information), supporting the hypothesis on the coordination of multiple mechanisms for neuronal migration in vivo.…”