Abstract:Viral macrophage inflammatory protein 2 (vMIP-II/vCCL2) binds to multiple chemokine receptors, and vMIP-II based PET tracer ( 64 Cu-DOTA-vMIP-II: vMIP-II tracer) accumulates at atherosclerotic lesions in mice. The magnitude of 64 Cu-DOTA-vMIP-II accumulation correlated with monocyte recruitment, as Apoe -/mice treated with AAV-mApoE showed PET signal declining as monocyte recruitment subsided. Unexpectedly, monocytes themselves were not the major target of the 64 Cu-DOTA-vMIP-II tracer.Using fluorescence-tagge… Show more
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