CXCL8 and the peritoneal metastasis of ovarian and gastric cancer

Abstract

CXCL8 is the most representative chemokine produced autocrine or paracrine by tumor cells, endothelial cells and lymphocytes. It can play a key role in normal tissues and tumors by activating PI3K-Akt, PLC, JAK-STAT, and other signaling pathways after combining with CXCR1/2. The incidence of peritoneal metastasis in ovarian and gastric cancer is extremely high. The structure of the peritoneum and various peritoneal-related cells supports the peritoneal metastasis of cancers, which readily produces a poor prognosis, low 5-year survival rate, and the death of patients. Studies show that CXCL8 is excessively secreted in a variety of cancers. Thus, this paper will further elaborate on the mechanism of CXCL8 and the peritoneal metastasis of ovarian and gastric cancer to provide a theoretical basis for the proposal of new methods for the prevention, diagnosis, and treatment of cancer peritoneal metastasis.

The prognostic risk model of ESCA patients was constructed based on intercellular-related genes

“…CXCL8, also known as interleukin-8 (IL-8), is a neutrophil-activating factor, which is mainly produced by neutrophils, monocytes, macrophages, T cells, epithelial cells, and endothelial cells. CXCL8 has the same expression trend in ovarian cancer, breast cancer, liver cancer [10][11][12] , head and neck squamous cell carcinoma, and has prognostic and diagnostic value 13 .…”

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“…Furthermore, CXCR1/CXCR2 expression has also been confirmed in non-immune cells, such as endothelial cells, fibroblasts, and tumor cells [5,12]. Due to their homology and ligand overlapping, the functions of CXCR1/CXCR2 have been clarified in many diseases [13].…”