CXCL5 is a potential diagnostic and prognostic marker for bladder cancer patients

Zhu, Xiaoyan; Qiao, Yan; Liu, Weihua; Wang, Wenying; Shen, Hongliang; Lu, Yi; Hao, Gangyue; Zheng, Jiajia; Tian, Ye

doi:10.1007/s13277-015-4275-4

Cited by 26 publications

(21 citation statements)

References 28 publications

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“…The protein levels of CXCL5 in colorectal tumor tissues were significantly higher than in normal tissues (23). In addition, high expression of CXCL5 in bladder cancer tissue was correlated with TNM stage, cancer grade, lymph node metastasis, as well as a shorter survival time (19). In the present study, we revealed for the first time that the expression of CXCL5 was markedly upregulated in glioma tissues compared to normal brain tissues, and its high expression was significantly associated with poor differentiation, advanced clinical stage, as well as a shorter survival time.…”

Section: Discussionmentioning

confidence: 89%

“…Moreover, CXCL5 is deregulated in human types of cancer, and plays a role in cancer cell proliferation, migration, and invasion (17,18). For instance, CXCL5 was found to be significantly upregulated in the urine samples of patients with bladder cancer, and high expression of CXCL5 in bladder cancer tissue was found to be correlated with TNM stage, cancer grade, lymph node metastasis, as well as a shorter survival time (19). Moreover, the CXCL5/CXCR2 axis can promote the migration and invasion of bladder cancer cells by activating the PI3K/AKT-induced upregulation of MMP2/MMP9 (17).…”

Section: Introductionmentioning

confidence: 99%

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CXCL5 promotes the proliferation and migration of glioma cells in autocrine- and paracrine-dependent manners

Dai

Chen

et al. 2016

Oncology Reports

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CXCL5 and its receptor CXCR2 have been found to be involved in tumorigenesis and cancer progression. Recent studies have shown that CXCR2 is upregulated in glioma tissues, and associated with poor prognosis and recurrence. However, the role of CXCL5/CXCR2 signaling in mediating the malignant phenotypes of glioma cells, as well as the underlying mechanism, still remains unclear. In the present study, we found that CXCL5 was upregulated in glioma tissues compared to that noted in normal brain tissues. High CXCL5 levels were significantly associated with higher tumor grade, advanced clinical stage, and shorter survival time of glioma patients. In vitro studies indicated that the protein expression levels of CXCL5 and CXCR2 were markedly higher in human glioma cell lines (U87, U251, U373 and A172), when compared with those in normal human gliocyte HEB cells. Overexpression of CXLC5 significantly promoted the proliferation and migration of U87 cells, while knockdown of CXCL5 by small interfering RNA markedly inhibited U87 cell proliferation and migration. Moreover, both exogenous CXCL5 treatment and the conditioned medium of CXCL5-overexpressing HEB cells also enhanced the proliferation and migration of U87 cells. Molecular mechanism investigation revealed that CXLC5 activated the ERK, JNK, p38 MAPK signaling pathways, which play key roles in tumor growth and metastasis. According to these data, our study suggests that CXCL5 plays a promoting role in glioma in autocrine- and paracrine-dependent manners.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

CXCL5 promotes the proliferation and migration of glioma cells in autocrine- and paracrine-dependent manners

Dai

Chen

et al. 2016

Oncology Reports

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“…Although great efforts have been made with respect to surgical resection combined with radiotherapy and chemotherapy, the overall survival time of patients with advanced BC remains unsatisfactory (3,4). In recent years, accumulating evidence has indicated that numreous oncogenes and tumor suppressors are dysregulated during the development and malignant progression of BC, some of which have been suggested to be potential therapeutic targets for BC (5–7). …”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑124 inhibits cell proliferation, invasion and migration by targeting CAV1 in bladder cancer

Zhou

Dai

et al. 2018

Exp Ther Med

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MicroRNAs (miRs) may have promotive or suppressive roles in various human cancers types, but the molecular mechanisms underlying the role of miR-124 in bladder cancer (BC) progression have remained largely elusive. In the present study, it was observed that miR-124 was significantly downregulated in BC tissues compared with that in adjacent non-neoplastic tissues. Furthermore, its expression was also reduced in several human BC cell lines (T24, HT-1376 and 5637) compared with that in the normal bladder epithelial SV-HUC-1 cell line. A low expression of miR-124 in BC patients was significantly associated with advanced malignancy and a poor prognosis. Caveolin 1 (CAV1) was identified as a novel target gene of miR-124, and the expression of CAV1 was negatively regulated by miR-124 in T24 cells. Furthermore, CAV1 was identified to be significantly upregulated in BC tissues and cell lines, and a negative correlation was observed between the expression of miR-124 and CAV1 in BC tissues. Furthermore, restoration of miR-124 expression significantly inhibited the proliferation, migration and invasion of T24 cells, and these effects were impaired following overexpression of CAV1. Taken together, the present results demonstrate that miR-124 has a suppressive role in the proliferation, migration and invasion of BC cells by targeting CAV1, which suggests that miR-124 is a potential therapeutic candidate for BC.

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“…C-X-C motif chemokine 5 (CXCL5), is a member of the C-X-C chemokine family, that acts as an important attractant for granulocytic immune cells by binding to its receptor C-X-C Chemokine Receptor Type 2 (CXCR2) [10] . CXCL5 overexpression has been observed in several malignancies, including osteosarcoma, glioma, and lung, bladder, liver, prostate and colorectal cancers [10][11][12][13][14][15][16] , demonstrating its roles in tumor carcinogenesis. Furthermore, CXCL5-CXCR2-dominated cross-talk between cancer cells and macrophages or neutrophils could promote tumor metastases in gastric, hepatocellular and prostate cancers [12,17,18] .…”

Section: Ivyspringmentioning

confidence: 99%

CXCL5 overexpression predicts a poor prognosis in pancreatic ductal adenocarcinoma and is correlated with immune cell infiltration

Liu¹,

Peng²,

Wang³

et al. 2020

J. Cancer

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Background: C-X-C motif chemokine 5 (CXCL5) is an important attractant for immune cell accumulation in tumor tissues. Recent evidence has shown that CXCL5 could promote carcinogenesis and cancer progression in a variety of cancer types. However, the relationships between CXCL5, immune cell infiltration and pancreatic ductal adenocarcinoma (PDAC) remain largely unknown. This study aimed to explore the role and regulative mechanism of CXCL5 in PDAC carcinogenesis. Materials and Methods: The expression of CXCL5 in PDAC was analyzed based on online databases and tissue microarray staining, and Western blotting of CXCL5 in PDAC cell lines and patient samples. The correlation between CXCL5 expression and clinicopathological features, prognosis and immune cell infiltration in tumor tissues was analyzed. Results: High expression of CXCL5 was observed both in PDAC tumor tissue and PDAC cell lines, compared to normal pancreas tissues and normal ductal epithelium cells. High CXCL5 expression in tumor tissues was positively correlated with an advanced T stage (p=0.036), a positive tumor lymph node metastasis (p=0.014), a poor differentiation status (p=0.003) and a poor prognosis (p=0.001). Combination of CA242 and CXCL5 expression (p<0.0001) served as a better prognostic factor than CA242 alone (p=0.006). In addition, PDAC patients with high CXCL5 expression had more intratumoral M2 polarized macrophages (p=0.0248), neutrophils (p=0.0068) and IgG + plasma cells (p=0.0133) than patients with low CXCL5 expression. Conclusions: The expression of CXCL5 is elevated in pancreatic cancer cells. High CXCL5 expression is positively correlated with poor survival and the increased infiltration of several types of immune suppressive cells. Thus, CXCL5 could be a promising therapeutic target for PDAC immunotherapy.

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CXCL5 is a potential diagnostic and prognostic marker for bladder cancer patients

Cited by 26 publications

References 28 publications

CXCL5 promotes the proliferation and migration of glioma cells in autocrine- and paracrine-dependent manners

CXCL5 promotes the proliferation and migration of glioma cells in autocrine- and paracrine-dependent manners

MicroRNA‑124 inhibits cell proliferation, invasion and migration by targeting CAV1 in bladder cancer

CXCL5 overexpression predicts a poor prognosis in pancreatic ductal adenocarcinoma and is correlated with immune cell infiltration

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