CXCL17 binds efficaciously to glycosaminoglycans with the potential to modulate chemokine signalling
Sean P. Giblin,
Sashini Ranawana,
Shyreen Hassibi
et al.
Abstract:CXCL17 is a mucosally secreted protein, and the most recently identified human chemokine, an assignment based on protein fold prediction and chemotactic activity for leukocytes. However, these credentials have been the subject of much recent discussion and no experimental evidence has been presented regarding the definitive structure of CXCL17. In this study, we evaluated the structural and chemoattractant credentials of CXCL17 to better characterise this molecule, and gain deeper insights into its functional … Show more
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