CXCL14 Inhibits Insulin Secretion Independently of CXCR4 or CXCR7 Receptor Activation or cAMP Inhibition

Abstract

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CXCL14‐like immunoreactivity in somatostatin‐producing cells of the Japanese quail (Coturnix japonica) pancreas

“…In the mouse pancreatic islets, CXCL14‐immunoreactive cells correspond to somatostatin‐producing cells (Atanes et al, 2019; Suzuki & Yamamoto, 2015). CXCL14 and somatostatin co‐localization in the same secretory granules has been previously demonstrated using immunoelectron microscopy (Suzuki & Yamamoto, 2015).…”

“…Suzuki and Yamamoto (2015) have postulated that CXCL14 secreted from somatostatin‐producing cells might inhibit somatostatin secretion in an autocrine manner. Atanes et al (2019) have revealed that CXCL14 inhibits insulin secretion through ATP level reduction in the mouse insulin‐producing cells. A previous study has reported significantly low serum insulin concentration in CXCL14 ‐deficient mice (Nara et al, 2007).…”

“…It is also involved in monocytederived tissue macrophage homeostasis (Kurth et al, 2001). In addition to its functions in the immune system, CXCL14 modulates the nervous and endocrine systems (Atanes et al, 2019;Nara et al, 2007;Suzuki et al, 2017;Suzuki & Yamamoto, 2015;Yamamoto et al, 2011Yamamoto et al, , 2020. Nara et al (2007) have described that serum insulin levels in CXCL14-deficient mice on high-fat diet were significantly lower than those in control mice.…”

“…Nara et al (2007) have described that serum insulin levels in CXCL14-deficient mice on high-fat diet were significantly lower than those in control mice. CXCL14 participates in insulin secretion as a local hormone in mouse pancreatic islets (Atanes et al, 2019;Suzuki & Yamamoto, 2015). Although molecular studies revealed that CXCL14 is widely conserved in vertebrates (Hara & Nakayama, 2009;Park et al, 2009), its distribution in the pancreatic islets has only been studied in mammals (Atanes et al, 2018(Atanes et al, , 2019Suzuki & Yamamoto, 2015).…”

The Chemokine Systems at the Crossroads of Inflammation and Energy Metabolism in the Development of Obesity

“…It is implicated that CXCL14 is important not only in the regulation of insulin-dependent glucose uptake in skeletal muscles but also in control of whole-body glucose metabolism. Nevertheless, the in vitro study has also shown that CXCL14 has the pro-diabetogenic effects to inhibit glucose-stimulated insulin secretion in mouse islets [53].…”