CXCL12 Signaling in the Development of the Nervous System

Mithal, Divakar S.; Banisadr, Ghazal; Miller, Richard J.

doi:10.1007/s11481-011-9336-x

Cited by 49 publications

(42 citation statements)

References 135 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SDF-1, which regulates neural-vascular system development, [11][12][13][17][18][19] is therefore a critical element of neural-vascular remodeling after ischemia-induced brain injury. Our data indicate that SDF-1α gene expression in the perifocal area 1 week after stroke is beneficial to neurogenesis and angiogenesis in the recovery phase.…”

Section: Discussionmentioning

confidence: 99%

“…[11][12][13][14][15] It is now recognized that SDF-1 regulates the development of nervous tissue, particularly because of its effects on cell migration and axon guidance.…”

mentioning

confidence: 99%

“…[11][12][13][14][15] It is now recognized that SDF-1 regulates the development of nervous tissue, particularly because of its effects on cell migration and axon guidance. 16 SDF-1 is also essential to the development of vasculature by recruiting Background and Purpose-Acute interventions of stroke are often challenged by a narrow treatment window.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Postacute Stromal Cell–Derived Factor-1α Expression Promotes Neurovascular Recovery in Ischemic Mice

Huang

et al. 2014

Stroke

View full text Add to dashboard Cite

A lthough the majority of patients with ischemic stroke survive with timely treatment in the acute phase, many still experience various long-term neurological deficits. 1 One of the obstacles to neurobehavioral recovery is limited spontaneous neurogenesis and angiogenesis in the postacute phase. Therapeutics that target the postacute phase with a wider treatment window would help improve functional recovery after stroke.Stromal cell-derived factor-1 (SDF-1), also called C-X-C motif chemokine ligand 12, functions by interacting with its receptor CXCR4, which is found on the cell surface of leucocytes and various kinds of stem cells.2-7 Previously, we have shown that blocking SDF-1/CXCR4 interaction suppresses inflammatory responses and reduces brain infarction in the acute phase of ischemic stroke. 8,9 In addition, CXCR4 gene transfer into the heart before myocardial ischemia enhances ischemia-reperfusion injury and increases the influx of inflammatory cells. 10 These results suggest that SDF-1 functions mainly as an inflammatory initiator during the acute phase of ischemia. However, the function of SDF-1 during the postacute phase of ischemia is still unknown.It is noteworthy that SDF-1 plays an important role during the development of the central nervous system and has a strong modulation effect on neurons, interneurons, and granule cells. [11][12][13][14][15] It is now recognized that SDF-1 regulates the development of nervous tissue, particularly because of its effects on cell migration and axon guidance.16 SDF-1 is also essential to the development of vasculature by recruiting Background and Purpose-Acute interventions of stroke are often challenged by a narrow treatment window. In this study, we explore treatments in the postacute phase of stroke with wider windows of opportunity. We investigated the effects of stromal cell-derived factor (SDF-1α) in neurovascular recovery during the postacute phase and downstream signaling pathways, underlying SDF-1α-mediated neurovascular recovery. Methods-Adult male Institute of Cancer Research (ICR) mice underwent middle cerebral artery occlusion. One week after middle cerebral artery occlusion, the animals received stereotactic injection of adenoassociated virus (AAV) carrying SDF-1α gene as treatment or AAV-green fluorescent protein as control and were monitored for 5 weeks. Neurobehavioral outcomes were evaluated, and brain atrophy was measured. Neurogenesis and angiogenesis were examined. The proliferation and migration of neural progenitor cells were evaluated. Downstream pathways of SDF-1α were investigated. Inflammatory response was monitored. Results-Neurobehavioral outcomes were improved, and brain atrophy was greatly reduced for ≤5 weeks in AAV-SDF-1α groups when compared with the control. SDF-1 receptor CXCR4 was upregulated and colocalized with neural and endothelial progenitor cells. Li et al SDF-1 Promotes Neurobehavioral Recovery 1823circulating endothelial progenitor cells (EPCs) involved in angiogenesis. [17][18][19][20][21][22] It is possible that SDF...

show abstract

Section: Discussionmentioning

confidence: 99%

“…[11][12][13][14][15] It is now recognized that SDF-1 regulates the development of nervous tissue, particularly because of its effects on cell migration and axon guidance.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Postacute Stromal Cell–Derived Factor-1α Expression Promotes Neurovascular Recovery in Ischemic Mice

Huang

et al. 2014

Stroke

View full text Add to dashboard Cite

show abstract

“…Interestingly, besides their involvement in a battery of processes in the immune system, chemokines and their receptors are expressed by all major cell types in the central nervous system (CNS), and a growing body of evidence shows that chemokines and their receptors mediate cellular communication in the CNS Mithal et al, 2012;Zhu and Murakami, 2012). For example, projection neurons in the intermediate zone (IZ)/subventricular zone (SVZ) of the cortex express Cxcl12 Tiveron et al, 2006), and regulate the tangential migration of Cxcr4-expressing GABAergic interneurons (López-Bendito et al, 2008;Tiveron et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons

et al. 2013

View full text Add to dashboard Cite

CXCL12/CXCR4 signaling has been reported to regulate three essential processes for the establishment of neural networks in different neuronal systems: neuronal migration, cell positioning and axon wiring. However, it is not known whether it regulates the development of A9-A10 tyrosine hydroxylase positive (TH + ) midbrain dopaminergic (mDA) neurons. We report here that Cxcl12 is expressed in the meninges surrounding the ventral midbrain (VM), whereas CXCR4 is present in NURR1 + mDA precursors and mDA neurons from E10.5 to E14.5. CXCR4 is activated in NURR1 + cells as they migrate towards the meninges. Accordingly, VM meninges and CXCL12 promoted migration and neuritogenesis of TH + cells in VM explants in a CXCR4-dependent manner. Moreover, in vivo electroporation of Cxcl12 at E12.5 in the basal plate resulted in lateral migration, whereas expression in the midline resulted in retention of TH + cells in the IZ close to the midline. Analysis of Cxcr4 −/− mice revealed the presence of VM TH + cells with disoriented processes in the intermediate zone (IZ) at E11.5 and marginal zone (MZ) at E14. Consistently, pharmacological blockade of CXCR4 or genetic deletion of Cxcr4 resulted in an accumulation of TH + cells in the lateral aspect of the IZ at E14, indicating that CXCR4 is required for the radial migration of mDA neurons in vivo. Altogether, our findings demonstrate that CXCL12/CXCR4 regulates the migration and orientation of processes in A9-A10 mDA neurons.

show abstract

“…The tissue modifications happening during inflammatory processes are intended for leukocytes recruitment from the circulation to the injured tissue with the purpose of destroying pathogens. Indeed, the majority of the cell movements implicated in the physiological tissue rearrangements and pathological conditions rely on chemokine driven signaling [8].…”

Section: A Brief Description Of Immune System Main Featuresmentioning

confidence: 99%

Biomedical Nanoparticles: Overview of Their Surface Immune-Compatibility

et al. 2014

View full text Add to dashboard Cite

Diagnostic-and therapeutic release-aimed nanoparticles require the highest degree of biocompatibility. Some physical and chemical characteristics of such nanomaterials are often at odds with this requirement. For instance, metals with specific features used as contrast agents in magnetic resonance imaging need particular coatings to improve their blood solubility and increase their biocompatibility. Other examples come from the development of nanocarriers exploiting the different characteristics of two or more materials, i.e., the ability to encapsulate a certain drug by one core-material and the targeting capability of a different coating surface. Furthermore, all these "human-non-self" modifications necessitate proofs of compatibility with the immune system to avoid inflammatory reactions and resultant adverse effects for the patient. In the present review we discuss the molecular interactions and responses of the immune system to the principal nanoparticle surface modifications used in nanomedicine.

show abstract

CXCL12 Signaling in the Development of the Nervous System

Cited by 49 publications

References 135 publications

Postacute Stromal Cell–Derived Factor-1α Expression Promotes Neurovascular Recovery in Ischemic Mice

Postacute Stromal Cell–Derived Factor-1α Expression Promotes Neurovascular Recovery in Ischemic Mice

Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons

Biomedical Nanoparticles: Overview of Their Surface Immune-Compatibility

Contact Info

Product

Resources

About