CXCL12/SDF-1 in IgG4-Related Disease

Capecchi, Riccardo; Croia, Cristina; Puxeddu, Ilaria; Pratesi, Federico; Cacciato, Andrea; Campani, Daniela; Boggi, Ugo; Morelli, Luca; Tavoni, Antonio; Migliorini, Paola

doi:10.3389/fphar.2021.750216

Cited by 5 publications

(2 citation statements)

References 41 publications

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“…This is also critical in IgG4-RD development. Regarding CXCR4, there was a study showing that its ligand CXCL12 was significantly increased in the serum and tissue of IgG4-RD patients and suggesting CXCL12/CXCR4 axis played important roles in the pathogenesis of this disorder [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

Single-Cell RNA-Sequencing Reveals Peripheral T Helper Cells Promoting the Development of IgG4-Related Disease by Enhancing B Cell Activation and Differentiation

Ji,

Lu,

et al. 2023

IJMS

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Abnormal B cell differentiation plays a critical role in IgG4-related disease (IgG4-RD), but the underlying mechanism remains largely unknown. We investigated the cell landscape from three IgG4-RD retroperitoneal tissues and three control tissues using single-cell RNA-sequencing. Critical cell type or markers were further validated in the peripheral blood from the patients with IgG4-RD and healthy controls via flow cytometry as well as in the IgG4-RD and control tissue via immunofluorescence staining. The increases in B cells, plasma cells, and CD4+ T cells were found in IgG4-RD retroperitoneal tissue. Importantly, among CD4+ T cells, an increase in CD4+CXCR5−PD1hi peripheral T helper (Tph) cells with a high expression of IL-21 and TIGIT was discovered in IgG4-RD tissue, which was further validated in peripheral blood of the patients with IgG4-RD. The Tph cell and TIGIT+ Tph cell proportion were remarkably higher in active IgG4-RD patients and correlated with disease activity. Moreover, TIGIT+CD4+ cells were able to promote B cell differentiation via IL-21. Our study revealed that Tph cells are increased in IgG4-RD and probably play critical roles in B cell differentiation through TIGIT-IL-21 axis. Peripheral Tph cell and TIGIT+Tph cell are potential markers for IgG4-RD disease activity.

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Section: Resultsmentioning

confidence: 99%

Single-Cell RNA-Sequencing Reveals Peripheral T Helper Cells Promoting the Development of IgG4-Related Disease by Enhancing B Cell Activation and Differentiation

Ji,

Lu,

et al. 2023

IJMS

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“…Ducts and acini produce CXCL-12 in IgG4-RDs affecting the pancreas ( 78 ). The receptor CXCR4 has also been detected in pancreatic lesions, but the type of cells expressing this receptor were not studied.…”

Section: Systemic Diseasesmentioning

confidence: 99%

Heterogeneity of antibody-secreting cells infiltrating autoimmune tissues

et al. 2023

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The humoral response is frequently dysfunctioning in autoimmunity with a frequent rise in total serum immunoglobulins, among which are found autoantibodies that may be pathogenic by themselves and/or propagate the inflammatory reaction. The infiltration of autoimmune tissues by antibody-secreting cells (ASCs) constitutes another dysfunction. The known high dependency of ASCs on the microenvironment to survive combined to the high diversity of infiltrated tissues implies that ASCs must adapt. Some tissues even within a single clinical autoimmune entity are devoid of infiltration. The latter means that either the tissue is not permissive or ASCs fail to adapt. The origin of infiltrated ASCs is also variable. Indeed, ASCs may be commonly generated in the secondary lymphoid organ draining the autoimmune tissue, and home at the inflammation site under the guidance of specific chemokines. Alternatively, ASCs may be generated locally, when ectopic germinal centers are formed in the autoimmune tissue. Alloimmune tissues with the example of kidney transplantation will also be discussed own to their high similarity with autoimmune tissues. It should also be noted that antibody production is not the only function of ASCs, since cells with regulatory functions have also been described. This article will review all the phenotypic variations indicative of tissue adaptation described so for at the level of ASC-infiltrating auto/alloimmune tissues. The aim is to potentially define tissue-specific molecular targets in ASCs to improve the specificity of future autoimmune treatments.

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