CXCL11 (Interferon-Inducible T-Cell Alpha Chemoattractant) and Interleukin-18 in Relapsing-Remitting Multiple Sclerosis Patients Treated with Methylprednisolone

Szczuciński, Adam; Kalinowska, Alicja; Losy, Jacek

doi:10.1159/000107945

Cited by 12 publications

(5 citation statements)

References 54 publications

(37 reference statements)

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“…Specifically, CXCL10 was higher in acute MS and lower in stable disease, suggesting a pathogenetic role for the chemokine in mediating clinical re-exacerbation of MS (45). In addition, the previously reported inverse correlation between CXCL10 levels and time from last clinical relapse, together with the finding that CXCL9, CXCL10, and CXCL11 are up-regulated during relapse in MS (46)(47)(48), strongly supports this hypothesis.…”

Section: Discussionsupporting

confidence: 59%

Increase of Interferon-γ Inducible CXCL9 and CXCL11 Serum Levels in Patients with Active Graves' Disease and Modulation by Methimazole Therapy

Antonelli

Ferrari

Corrado

et al. 2013

Thyroid

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Section: Discussionsupporting

confidence: 59%

Increase of Interferon-γ Inducible CXCL9 and CXCL11 Serum Levels in Patients with Active Graves' Disease and Modulation by Methimazole Therapy

Antonelli

Ferrari

Corrado

et al. 2013

Thyroid

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“…These activated basophils also could induce the development of Th-2 cells [ 106 ]. Moreover, it stimulates other cytokine production such as IL-1β, IL-6, IL-17, TNF-a, CRP, and chemokines, which are engaged in host innate defense and cytokine storm leading to ARDS [ 103 , 112 ].…”

Section: Il-18 and Covid-19mentioning

confidence: 99%

The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19

et al. 2022

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A global pandemic has erupted as a result of the new brand coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic has been consociated with widespread mortality worldwide. The antiviral immune response is an imperative factor in confronting the recent coronavirus disease 2019 (COVID-19) infections. Meantime, cytokines recognize as crucial components in guiding the appropriate immune pathways in the restraining and eradication of the virus. Moreover, SARS-CoV-2 can induce uncontrolled inflammatory responses characterized by hyper-inflammatory cytokine production, which causes cytokine storm and acute respiratory distress syndrome (ARDS). As excessive inflammatory responses are contributed to the severe stage of the COVID-19 disease, therefore, the pro-inflammatory cytokines are regarded as the Achilles heel during COVID-19 infection. Among these cytokines, interleukin (IL-) 1 family cytokines (IL-1, IL-18, IL-33, IL-36, IL-37, and IL-38) appear to have a strong inflammatory role in severe COVID-19. Hence, understanding the underlying inflammatory mechanism of these cytokines during infection is critical for reducing the symptoms and severity of the disease. Here, the possible mechanisms and pathways involved in inflammatory immune responses are discussed.

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“…CXCL11 could bind to CXCR3 expressed on CD8 + and CD4 + T cells. 30 Elevated serum levels of CXCL11 were found to be related to multiple sclerosis 31 and traumatic brain injury. 32 It is speculated that increased CXCL11 levels could facilitate the recruitment of activated Th1 cells and initiate a protective response of the inflammation sites.…”

Section: Discussionmentioning

confidence: 99%

Identification of Plasma Inflammatory Markers of Adolescent Depression Using the Olink Proteomics Platform

Yang,

Cao,

Tian

et al. 2023

JIR

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Purpose The quality of life of worldwide adolescents has been seriously affected by depression. Notably, the inflammatory response is closely associated with the pathophysiology of depression. The present study applied a novel targeted proteomics technology, Olink proximity extension assay (PEA), to profile circulating immune-related proteins in adolescents with depression. Methods In the present study, the expression levels of 92 inflammation-related proteins were compared between adolescents with depression (ADs) (n=15) and healthy controls (HCs) (n=15), using the OLINK PEA inflammation panel. We further validated 5 top proteins that were identified through KEGG and GO analyses between 40 HCs and 50 ADs, including CCL4, CXCL5, CXCL6, CXCL11, and IL-18 using enzyme linked immunosorbent assay (ELISA). Results We identified 13 differentially expressed proteins between the two cohorts, including 5 up-regulated and 8 down-regulated proteins. Among them, the TRAIL protein levels were significantly negatively correlated with the HAMA-14 score (r=−0.538, p= 0.038), and the levels of transforming growth factor α (TGF-α) were significantly associated with a change in appetite (r = -0.658, p = 0.008). After validation by ELISA, CCL4, CXCL5, CXCL11, and IL-18 showed significant changes between ADs and HCs (p < 0.05), while CXCL6 showed an up-regulated tendency in ADs (p=0.0673). The pooled diagnostic efficacy (area under the curve [AUC]) of these five inflammation markers in clinical diagnosis for adolescent depression was 0.819 (95% CI: 0.735–0.904). Conclusion We report a number of inflammation-related plasma biomarkers, which uncover a potential involvement of chemokines, cytokines, and cytokine receptors in adolescent depression. Their roles in the pathophysiology of depression need to be further elucidated.

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CXCL11 (Interferon-Inducible T-Cell Alpha Chemoattractant) and Interleukin-18 in Relapsing-Remitting Multiple Sclerosis Patients Treated with Methylprednisolone

Cited by 12 publications

References 54 publications

Increase of Interferon-γ Inducible CXCL9 and CXCL11 Serum Levels in Patients with Active Graves' Disease and Modulation by Methimazole Therapy

Increase of Interferon-γ Inducible CXCL9 and CXCL11 Serum Levels in Patients with Active Graves' Disease and Modulation by Methimazole Therapy

The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19

Identification of Plasma Inflammatory Markers of Adolescent Depression Using the Olink Proteomics Platform

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