CXCL10 produced from hair follicles induces Th1 and Tc1 cell infiltration in the acute phase of alopecia areata followed by sustained Tc1 accumulation in the chronic phase

Ito, Taisuke; Hashizume, Hideo; Shimauchi, Takatoshi; Funakoshi, Akihiro; Ito, Natsuho; Fukamizu, Hidekazu; Takigawa, Masaharu; Tokura, Y.

doi:10.1016/j.jdermsci.2012.12.003

Cited by 73 publications

(58 citation statements)

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“…Furthermore, skin infiltrating T cells of an acute phase AA lesion from one patient, which were isolated as previously described [5], also showed an increased number of MAGE-A3…”

Section: Dear Editorsupporting

confidence: 58%

Birth, life, and death of the MAGE3 hypothesis of alopecia areata pathobiology

Ito

Bertolini

Funakoshi

et al. 2013

Journal of Dermatological Science

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“…Furthermore, skin infiltrating T cells of an acute phase AA lesion from one patient, which were isolated as previously described [5], also showed an increased number of MAGE-A3…”

Section: Dear Editorsupporting

confidence: 58%

Birth, life, and death of the MAGE3 hypothesis of alopecia areata pathobiology

Ito

Bertolini

Funakoshi

et al. 2013

Journal of Dermatological Science

Self Cite

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“…On the other hand, it has been suggested that the CD8 + T cells around hair bulbs contribute to hair loss in the chronic phase of AA. 3 UVB radiation has immunosuppressive effects, for example, it induces Tcell apoptosis, 4 and reductions in the numbers of both CD4 + and CD8 + cells have been detected after the irradiation of psoriatic lesions with narrowband (NB)-UVB 5 therefore, it may be effective at treating AA. Unfortunately, NB-UVB was concluded to be ineffective against AA in a retrospective analysis of the cases of 25 patients.…”

Section: Discussionmentioning

confidence: 99%

“…2 AU is usually resistant to therapy; therefore, further investigations into new treatments for the condition are needed. The 308-nm excimer light (equivalent to an excimer lamp) is a system that delivers long-wave monochromatic ultraviolet (UV)B radiation, which is known to induce T-cell apoptosis in vitro, 3 and has recently been reported to be useful for treating patchy AA in several clinical studies. 4,5 However, only a few patients with the severe forms of AA were included in these studies, and all of them exhibited poor outcomes.…”

Section: Introductionmentioning

confidence: 99%

Three hundred and eight nanometer excimer light therapy for alopecia universalis that is resistant to other treatments: A clinical study of 11 patients

Arakawa

Nomiyama

Katoh

2016

The Journal of Dermatology

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Three hundred and eight nanometer excimer light therapy has recently been reported to be effective against patchy alopecia areata (AA) in several clinical studies. However, these studies only included a few patients with severe forms of AA, and all of them exhibited poor outcomes. We further investigated the use of excimer light as a therapeutic option for cases of alopecia universalis (AU) that are resistant to other treatments. Eleven treatmentresistant AU patients were treated with a 308-nm excimer light at 2-week intervals for more than 16 sessions. Four patients achieved good responses and two patients exhibited poor responses. Three patients had Japanese skin type 1 and all of them achieved good responses. The radiation dose was increased until the patients exhibited marked erythema. The patients with Japanese skin type 3 who achieved good responses exhibited strong pigmentation at the irradiated sites. In conclusion, 308-nm excimer light therapy has significant effects on some AU patients who are resistant to other treatments and may be an alternative therapeutic option for AU. During the treatment of AU, high doses of radiation should be administrated until a strong inflammatory skin reaction is seen.

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“…For example, Nakamura et al indicated the Th1-predominant lymphocytic infi ltration around hair follicles of patients with alopecia areata [18]. In another study, Ito et al demonstrated that patients with acute AA have a higher frequency of circulating CXCR3+ CD4+ Th1 cells [19].…”

Section: Discussionmentioning

confidence: 99%

Study of Th1/Th2 balance in peripheral blood mononuclear cells of patients with alopecia areata

Sadeghi

Sanati

Taghizadeh

et al. 2015

Acta Microbiologica et Immunologica Hungarica

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Alopecia areata represents an autoimmune pathological process driven primarily by cellular aberrations contained within the immune system, which activates various humoral and cellular elements of the immune response. The aim of this study was to determine the mRNA expression levels of T-bet and GATA-3 as potential inducers of T helper (Th)1 and Th2 differentiation, respectively, as well as Th1(IFN-γ) and Th2(IL-4) cytokine mRNA expression in patients with alopecia areata. Using real-time reverse transcriptase PCR (RT-PCR), the relative amounts of T-bet, GATA-3, IFN-γ, and IL-4 mRNA transcripts were determined in PBMCs from 20 Iranian patients with alopecia areata and compared with those of 20 healthy control subjects. In comparison with the normal group, T-bet and IFN-γ mRNA expression levels were signifi cantly up-regulated in the alopecia areata patients, while GATA-3 and IL-4 mRNA expression levels were down-regulated. Notably, positive correlation (P < 0.05) was found between IFN-γ and T-bet levels in patients and controls. In addition, signifi cant positive correlations existed between GATA-3 and IL-4 (P < 0.05). These results indicate that a Th1/Th2 imbalance exists in alopecia areata, and it may be implicated in the pathogenesis of disease.

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CXCL10 produced from hair follicles induces Th1 and Tc1 cell infiltration in the acute phase of alopecia areata followed by sustained Tc1 accumulation in the chronic phase

Cited by 73 publications

References 50 publications

Birth, life, and death of the MAGE3 hypothesis of alopecia areata pathobiology

Birth, life, and death of the MAGE3 hypothesis of alopecia areata pathobiology

Three hundred and eight nanometer excimer light therapy for alopecia universalis that is resistant to other treatments: A clinical study of 11 patients

Study of Th1/Th2 balance in peripheral blood mononuclear cells of patients with alopecia areata

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