CXC Chemokine Receptor 4 Is Expressed Paravascularly in Apical Papilla and Coordinates with Stromal Cell–derived Factor-1α during Transmigration of Stem Cells from Apical Papilla

Liu, Jing-Yi; Chen, Xue; Lin, Yan; Huang, George T.‐J.; Zou, Xiaoying

doi:10.1016/j.joen.2015.04.006

Cited by 35 publications

(29 citation statements)

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“…The chemotactic effect of the cytokine SDF‐1α was further studied on SCAP by Liu et al . () using in vitro transmigration models. SDF‐1α is widely expressed and mediates cell migration through its binding with CXC chemokine receptor 4 (CXCR4).…”

Section: Resultsmentioning

confidence: 99%

Dental pulp regeneration via cell homing

et al. 2017

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Eramo S, Natali A, Pinna R, Milia E. Dental pulp regeneration via cell homing. International Endodontic Journal, 51, 405-419, 2018. The typical treatment for irreversibly inflamed/necrotic pulp tissue is root canal treatment. As an alternative approach, regenerative endodontics aims to regenerate dental pulp-like tissues using two possible strategies: cell transplantation and cell homing. The former requires exogenously transplanted stem cells, complex procedures and high costs; the latter employs the host's endogenous cells to achieve tissue repair/ regeneration, which is more clinically translatable. This systematic review examines cell homing for dental pulp regeneration, selecting articles on in vitro experiments, in vivo ectopic transplantation models and in situ pulp revascularization. MEDLINE/PubMed and Scopus databases were electronically searched for articles without limits in publication date. Two reviewers independently screened and included papers according to the predefined selection criteria. The electronic searches identified 46 studies. After title, abstract and full-text examination, 10 articles met the inclusion criteria. In vitro data highlighted that multiple cytokines have the capacity to induce migration, proliferation and differentiation of dental pulp stem/ progenitor cells. The majority of the in vivo studies obtained regenerated connective pulp-like tissues with neovascularization. In some cases, the samples showed new innervation and new dentine deposition. The in situ pulp revascularization regenerated intracanal pulp-like tissues with neovascularization, innervation and dentine formation. Cell homing strategies for pulp regeneration need further understanding and improvement if they are to become a reliable and effective approach in endodontics. Nevertheless, cell homing currently represents the most clinically viable pathway for dental pulp regeneration.

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Section: Resultsmentioning

confidence: 99%

Dental pulp regeneration via cell homing

et al. 2017

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“…It is plausible that locally populated MSCs from periapical region, including PDLSCs, SCAP, and alveolar BMSCs account for recruitment. 79,80 In addition, systematically circulated stem/progenitor cells appear clinically available. 75 However, regarding the regenerated pulp-dentin anatomically mimicking native tissue, periapical stem cells appear less therapeutically applicable and feasible as compared with PSCs.…”

Section: Cell Transplantation-based Regenerative Endodonticsmentioning

confidence: 99%

“…In cases of advanced pulpitis or necrosis, pulp is then extirpated completely. It is plausible that locally populated MSCs from periapical region, including PDLSCs, SCAP, and alveolar BMSCs account for recruitment . In addition, systematically circulated stem/progenitor cells appear clinically available .…”

Section: Introductionmentioning

confidence: 99%

“…A variety of exogenous growth factors have been determined in vitro on their potentials in enhancing PSC migration, proliferation, and differentiation. Regarding induced migration, SDF‐1, basic fibroblast growth factor (bFGF), stem cell factor (SCF), and granulocyte‐colony stimulating factor (GCSF) exhibit superior potentials. Considering the proliferation, SCF, bFGF and GCSF, as well as Wnt3a are capable of promoting cell proliferation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pulp stem cells derived from human permanent and deciduous teeth: Biological characteristics and therapeutic applications

Shi

Mao

Liu

2020

Stem Cells Translational Medicine

156

128

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Human pulp stem cells (PSCs) include dental pulp stem cells (DPSCs) isolated from dental pulp tissues of human extracted permanent teeth and stem cells from human exfoliated deciduous teeth (SHED). Depending on their multipotency and sensitivity to local paracrine activity, DPSCs and SHED exert therapeutic applications at multiple levels beyond the scope of the stomatognathic system. This review is specifically concentrated on PSC‐updated biological characteristics and their promising therapeutic applications in (pre)clinical practice. Biologically, distinguished from conventional mesenchymal stem cell markers in vitro, NG2, Gli1, and Celsr1 have been evidenced as PSC markers in vivo. Both perivascular cells and glial cells account for PSC origin. Therapeutically, endodontic regeneration is where PSCs hold the most promises, attributable of PSCs' robust angiogenic, neurogenic, and odontogenic capabilities. More recently, the interplay between cell homing and liberated growth factors from dentin matrix has endowed a novel approach for pulp‐dentin complex regeneration. In addition, PSC transplantation for extraoral tissue repair and regeneration has achieved immense progress, following their multipotential differentiation and paracrine mechanism. Accordingly, PSC banking is undergoing extensively with the intent of advancing tissue engineering, disease remodeling, and (pre)clinical treatments.

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“…CD105 expression in the apical papilla also appears to be associated with blood vessels [34]. NOTCH3 and CXCR4 were also found to be expressed paravascularly [35,36].…”

Section: Scap Nichementioning

confidence: 96%