CX43 Expression in Colonic Adenomas and Surrounding Mucosa Is a Marker of Malignant Potential

Bišćanin, Alen; Ljubičić, Neven; Boban, Marko; Baličević, Drinko; Pavić, Ivana; Bišćanin, Mirela Maver; Budimir, Ivan; Dorosulić, Zdravko; Duvnjak, Marko

doi:10.21873/anticanres.11122

Cited by 9 publications

(4 citation statements)

References 18 publications

(27 reference statements)

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“…Connexin 43 is a member of the connexin family and known for its greater capacity for transporting macromolecules than other connexin proteins [18].Compelling evidence suggests that dysregulated Cx43 (GJA1) expression is associated with tumor development and progression [19][20][21], making Cx43 an attractive tumor biomarker.…”

Section: Discussionmentioning

confidence: 99%

GJA1 rs2071165 A > G Variant Increased Gastric Cancer Risk in Females of Northwest China: A Case-Control Study

Yuan

Yang

Wei

et al. 2021

Journal of Oncology

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Gastric cancer (GC) is one of the most common malignancies, and its incidence rates vary widely between men and women. Previous studies have suggested that connexin 43 (Cx43, encoded by gap junction protein alpha 1 (GJA1)) and secretory carrier membrane protein 1 (SCAMP1) are key functional proteins in tumors. Herein, the association between GJA1 and SCAMP1 polymorphisms and GC susceptibility and prognosis was evaluated. A total of three single-nucleotide polymorphisms among 681GC patients and 756 controls were tested using the Agena MassARRAY RS1000 system, including GJA1 rs2071165, SCAMP1 rs4530741, and SCAMP1 rs6874309. The strength of the association with GC risk was assessed by the odds ratios (ORs) and 95% confidence intervals (CIs) generated from the logistic regression model. Kaplan–Meier curve, long-rank tests, and a multivariate Cox proportional hazard model were used for prognosis analysis. The expression of GJA1 was assessed by immunohistochemistry. The GJA1 rs2071165 AA/AG genotype significantly increased the risk of GC in the female Chinese population (OR = 1.55, 95% CI = 1.03–2.32, p = 0.034 ). Furthermore, the risk effect of GJA1 rs2071165 was more evident in the subgroups of female patients with GC, stratified by age, clinical stage, tumor size, and recurrence/metastasis. However, no obvious differences in Cx43 expression in GC tissues were observed between males and females. Furthermore, no significant association between SCAMP1 rs4530741 and rs6874309 polymorphisms and GC risk or prognosis was observed. In conclusion, this study suggests for the first time that the GJA1 rs2071165 polymorphism is associated with increased GC risk in females, revealing a potential new clinical marker for assessing GC risk in females.

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Section: Discussionmentioning

confidence: 99%

GJA1 rs2071165 A > G Variant Increased Gastric Cancer Risk in Females of Northwest China: A Case-Control Study

Yuan

Yang

Wei

et al. 2021

Journal of Oncology

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“…Chromosomal instability (CIN), as an essential molecular pathway of malignant transformation, mainly affects genes such as APC , KRAS , PIK3CA , and TP53 [ 18 ]. In addition, the adenoma–carcinoma sequence offers potential for screening and surveillance; e.g., connexin 43 expression in colonic adenomas is linked with high-grade dysplasia and colonic mucosa surrounding adenomas [ 19 ]. APC mutations lead to nuclear beta-catenin translocations and the transcription of genes participating in carcinogenesis and invasion processes.…”

Section: Etiology Of Colorectal Cancermentioning

confidence: 99%

Profiling Colorectal Cancer in the Landscape Personalized Testing—Advantages of Liquid Biopsy

Verbanac

Čeri

Hlapčić

et al. 2021

IJMS

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Drug-specific therapeutic approaches for colorectal cancer (CRC) have contributed to significant improvements in patient health. Nevertheless, there is still a great need to improve the personalization of treatments based on genetic and epigenetic tumor profiles to maximize the quality and efficacy while limiting cytotoxicity. Currently, CEA and CA 19-9 are the only validated blood biomarkers in clinical practice. For this reason, laboratories are trying to identify new specific prognostics and, more importantly, predictive biomarkers for CRC patient profiling. Thus, the unique landscape of personalized biomarker data should have a clinical impact on CRC treatment strategies and molecular genetic screening tests should become the standard method for diagnosing CRC. This review concentrates on recent molecular testing in CRC and discusses the potential modifications in CRC assay methodology with the upcoming clinical application of novel genomic approaches. While mechanisms for analyzing circulating tumor DNA have been proven too inaccurate, detecting and analyzing circulating tumor cells and protein analysis of exosomes represent more promising options. Blood liquid biopsy offers good prospects for the future if the results align with pathologists’ tissue analyses. Overall, early detection, accurate diagnosis and treatment monitoring for CRC with specific markers and targeted molecular testing may benefit many patients.

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“…25 Interestingly, there is also evidence of correlation of higher level of stromal expression of GJA1 with more advanced clinical stage of CRC. 26,27 These contradictory findings indicate further investigation of GJA1 as a potential prognostic biomarker in CRC and the underlying mechanisms are warranted.…”

Section: Gja1 Modulated the Infiltration Of Immune Cells Of Crc Micromentioning

confidence: 99%

<p>GJA1 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Colorectal Cancer</p>

Hu¹,

Li²,

Zhang³

et al. 2020

CMAR

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CX43 Expression in Colonic Adenomas and Surrounding Mucosa Is a Marker of Malignant Potential

Abstract: CX43 expression in mucosa surrounding adenoma could be an additional factor indicative of malignant potential. CX43 expression in colonic adenoma seems to be closely related to family history of colorectal cancer, statin therapy and hemoglobin level.

Cited by 9 publications

References 18 publications

GJA1 rs2071165 A > G Variant Increased Gastric Cancer Risk in Females of Northwest China: A Case-Control Study

GJA1 rs2071165 A > G Variant Increased Gastric Cancer Risk in Females of Northwest China: A Case-Control Study

Profiling Colorectal Cancer in the Landscape Personalized Testing—Advantages of Liquid Biopsy

<p>GJA1 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Colorectal Cancer</p>

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