Meejin Ahn, Jonathan Lee, Andreas Gustafsson, Alan Enriquez, Eric Lancaster, Jai-Yoon Sul, Philip G. Haydon, David L. Paul, Yan Huang, Charles K. Abrams, Steven S. Scherer
Abstract:In rodents, oligodendrocytes and myelinating Schwann cells express connexin32 (Cx32) and Cx29, which have different localizations in the two cell types. We show here that, in contrast to Cx32, Cx29 does not form gap junction plaques or functional gap junctions in transfected cells. Furthermore, when expressed together, Cx29 and Cx32 are not colocalized and do not coimmunoprecipitate. To determine the structural basis of their divergent behavior, we generated a series of chimeric Cx32-Cx29 proteins by exchangin…
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