Conservation Voltage Reduction (CVR) has been traditionally applied adopting moderate settings at primary substations and when distributed generation was uncommon. However, as new infrastructure is deployed across Europeanstyle MV and LV networks, driven by increasing photovoltaic (PV) penetration levels, the opportunity arises to develop more advanced CVR schemes. This work proposes a centralized, threephase AC OPF-based CVR scheme that, using monitoring, onload tap changers (OLTCs) and capacitors across MV and LV, actively manages voltages to minimize energy consumption, even with high PV penetration, whilst considering MV-LV constraints. To tackle scalability issues brought by discrete variables, a twostage approach is proposed to solve the OPF as a non-linear programming problem (relaxing integer variables). A process that continuously checks customer voltages is adopted to trigger the optimization only when needed. Moreover, CVR benefits are not only quantified at a network level but also for customers, providing useful insights to policy makers. The proposed control is assessed using a realistic, unbalanced UK residential MV-LV network (2,400+ customers) with high PV penetration, and 1-min resolution time-varying profiles and load models. Results demonstrate that the proposed control effectively coordinates voltage regulation in MV and LV levels throughout the day, minimizing energy imports for all customers.