Cutting in choline

Deane, Caitlin

doi:10.1038/s41589-018-0218-x

Cited by 4 publications

(4 citation statements)

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“…It can also be metabolized to fumarate and acetoacetate, which are intermediates in the TCA cycle and can be used to produce energy or synthesize fatty acids. The observed decrease in phenylalanine and tyrosine could account for the enhanced utilization of fatty acids as a source of energy and biomass in tumors 17 . Tryptophan is involved in kynurenine, serotonin, and indole synthesis, and the tryptophan‐kynurenine metabolic pathway is strongly activated in response to interferons and other cytokines released upon inflammation 18 .…”

Section: Discussionmentioning

confidence: 99%

“…In PCa observed decrease in phenylalanine and tyrosine could account for the enhanced utilization of fatty acids as a source of energy and biomass in tumors. 17 Tryptophan is involved in kynurenine, serotonin, and indole synthesis, and the tryptophan-kynurenine metabolic pathway is strongly activated in response to interferons and other cytokines released upon inflammation. 18 Our observation of decreased tryptophan not only supports this hypothesis but also suggests tryptophan's potential role as a biomarker for diseases characterized by excessive or chronic inflammation, including malignancies.…”

Section: Potential Contributing Metabolites (Hmbd Id)mentioning

confidence: 99%

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Differentiation of patients with and without prostate cancer using urine ¹H NMR metabolomics

Hasubek,

Wang,

Zhang

et al. 2023

Magnetic Reson in Chemistry

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Prostate cancer (PCa) is one of the most prevalent cancers in men worldwide. For its detection, serum prostate‐specific antigen (PSA) screening is commonly used, despite its lack of specificity, high false positive rate, and inability to discriminate indolent from aggressive PCa. Following increases in serum PSA levels, clinicians often conduct prostate biopsies with or without advanced imaging. Nuclear magnetic resonance (NMR)‐based metabolomics has proven to be promising for advancing early‐detection and elucidation of disease progression, through the discovery and characterization of novel biomarkers. This retrospective study of urine‐NMR samples, from prostate biopsy patients with and without PCa, identified several metabolites involved in energy metabolism, amino acid metabolism, and the hippuric acid pathway. Of note, lactate and hippurate—key metabolites involved in cellular proliferation and microbiome effects, respectively—were significantly altered, unveiling widespread metabolomic modifications associated with PCa development. These findings support urine metabolomics profiling as a promising strategy to identify new clinical biomarkers for PCa detection and diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Potential Contributing Metabolites (Hmbd Id)mentioning

confidence: 99%

Differentiation of patients with and without prostate cancer using urine ¹H NMR metabolomics

Hasubek,

Wang,

Zhang

et al. 2023

Magnetic Reson in Chemistry

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“…Tumor cells require a high uptake of choline to synthesize cellular membranes. , In clinical practice, 11 C-/ 18 F-labeled choline PET/CT technique is commonly used to diagnose PCa , and assess the therapeutic effect of PCa . Moreover, choline can also be transformed into trimethylamine (TMA) and then oxidized to trimethylamine N-oxide (TMAO) by the hepatic enzyme . Increased serum TMAO level has been reported to be associated with a high risk of aggressive PCa .…”

Section: Discussionmentioning

confidence: 99%

“…35 Moreover, choline can also be transformed into trimethylamine (TMA) and then oxidized to trimethylamine N-oxide (TMAO) by the hepatic enzyme. 36 Increased serum TMAO level has been reported to be associated with a high risk of aggressive PCa. 37 In this study, as expected, we observed a significantly higher concentration of choline in HSPC relative to BPH.…”

Section: Discussionmentioning

confidence: 99%

Distinct Metabolic Signatures of Hormone-Sensitive and Castration-Resistant Prostate Cancer Revealed by a ¹H NMR-Based Metabolomics of Biopsy Tissue

et al. 2020

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Tumor metabolic characteristics have been associated with the progression of prostate cancer (PCa), but little information is available regarding the metabolic alterations from hormone-sensitive (HSPC) to castration-resistant PCa (CRPC). In this study, therefore, we investigated the metabolic profiles in prostate tissues from patients with benign prostatic hyperplasia (BPH), HSPC, and CRPC using a 1 H NMR-based metabolomics approach. The results show that clear separations in metabolic patterns were obtained in prostate tissues among BPH, HSPC, and CRPC; however, CRPC may induce a metabolic shift toward BPH, mainly involving amino acid metabolism, choline metabolism, and the Warburg effect. Based on these metabolic changes, we identified potential biomarker panels for the discrimination between BPH vs HSPC, BPH vs CRPC, and HSPC vs CRPC with the AUC values of 0.995, 0.972, and 0.937, respectively. Collectively, tissuebased metabolomics analysis not only identifies the altered metabolic pathways during PCa progression but also has the potential to help the classification and diagnosis of PCa in clinical practice.

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NMR-based metabolomics analysis identifies discriminatory metabolic disturbances in tissue and biofluid samples for progressive prostate cancer

Zheng

Dong

Ning

et al. 2020

Clinica Chimica Acta

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Cutting in choline

Cited by 4 publications

References 0 publications

Differentiation of patients with and without prostate cancer using urine ¹H NMR metabolomics

Differentiation of patients with and without prostate cancer using urine ¹H NMR metabolomics

Distinct Metabolic Signatures of Hormone-Sensitive and Castration-Resistant Prostate Cancer Revealed by a ¹H NMR-Based Metabolomics of Biopsy Tissue

NMR-based metabolomics analysis identifies discriminatory metabolic disturbances in tissue and biofluid samples for progressive prostate cancer

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Cutting in choline

Cited by 4 publications

References 0 publications

Differentiation of patients with and without prostate cancer using urine 1H NMR metabolomics

Differentiation of patients with and without prostate cancer using urine 1H NMR metabolomics

Distinct Metabolic Signatures of Hormone-Sensitive and Castration-Resistant Prostate Cancer Revealed by a 1H NMR-Based Metabolomics of Biopsy Tissue

NMR-based metabolomics analysis identifies discriminatory metabolic disturbances in tissue and biofluid samples for progressive prostate cancer

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Differentiation of patients with and without prostate cancer using urine ¹H NMR metabolomics

Differentiation of patients with and without prostate cancer using urine ¹H NMR metabolomics

Distinct Metabolic Signatures of Hormone-Sensitive and Castration-Resistant Prostate Cancer Revealed by a ¹H NMR-Based Metabolomics of Biopsy Tissue