Cutting Edge: Progesterone Directly Upregulates Vitamin D Receptor Gene Expression for Efficient Regulation of T Cells by Calcitriol

Thangamani, Shankar; Kim, Myughoo; Son, Young-Min; Huang, Xinxin; Kim, Hee Joo; Lee, Jee H.; Cho, Jungyoon; Ulrich, Bernd; Broxmeyer, Hal E.; Kim, Chang H.

doi:10.4049/jimmunol.1401923

Cited by 26 publications

(20 citation statements)

References 27 publications

(28 reference statements)

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“…This process is important for the menstrual cycle, mammary gland development, and pregnancy maintenance. Recently, we discovered that P4 induces vitamin D receptor (VDR) expression (Thangamani et al, 2015). We observed this regulation in T cells, and therefore, the immediate impact of our finding is on immune regulation (Fig.…”

supporting

confidence: 57%

“…We found that calcitriol becomes highly effective in regulating T cells when P4 is present at the same time (Thangamani et al, 2015). P4 enhances the T-cell response to calcitriol by three to five times.…”

Section: Vitamin D Receptor Induction By P4 and Its Impact On The Immmentioning

confidence: 74%

“…Active forms of vit. D such as calcitriol regulate T-cell maturation into effector and regulatory T cells (Boonstra et al, 2001;Gorman et al, 2007;Thangamani et al, 2015). Calcitriol suppresses naive T-cell differentiation into Th1 and Th17 cells, but reciprocally enhances T-cell differentiation into regulatory T cells.…”

Section: Vitamin D Is Another Immune-regulatory Steroid Hormonementioning

confidence: 99%

“…The regulatory T cells induced by calcitriol are a mixture of FoxP3 + and FoxP3 -regulatory T cells and express regulatory cell-associated CD25, FoxP3, CD38, and/or LAP-TGF-b1 (Stoeckler et al, 1996;Kang et al, 2012;Thangamani et al, 2015). In a manner somewhat similar to P4, vit.…”

Section: Vitamin D Is Another Immune-regulatory Steroid Hormonementioning

confidence: 99%

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A Functional Relay from Progesterone to Vitamin D in the Immune System

Kim

2015

DNA and Cell Biology

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Progesterone is a steroid hormone that promotes and maintains pregnancy. Vitamin D (vit. D), another steroid hormone, regulates calcium levels and bone health among many of its functions. The two hormones play important roles also in regulating the immune system. Recently, we discovered that the vitamin D receptor (VDR) is induced in T cells by progesterone. This finding connects the function of progesterone to that of vit. D and suggests that the two steroid hormones cooperate with each other for sequential and effective regulation of the immune system. Potential implications of the regulation in health and disease are discussed.

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supporting

confidence: 57%

Section: Vitamin D Receptor Induction By P4 and Its Impact On The Immmentioning

confidence: 74%

Section: Vitamin D Is Another Immune-regulatory Steroid Hormonementioning

confidence: 99%

Section: Vitamin D Is Another Immune-regulatory Steroid Hormonementioning

confidence: 99%

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A Functional Relay from Progesterone to Vitamin D in the Immune System

Kim

2015

DNA and Cell Biology

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“…3 guided in concert T cells from a pro-inflammatory (Th1 and Th17) to a more regulatory profile [434] . A synergistic effect of 1,25(OH) 2 …”

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confidence: 99%

Mapping the effects of vitamin D in multiple sclerosis

Rolf¹

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Columbus (1451Columbus ( -1506 on one of his four voyages Er zijn verrassend veel parallellen te trekken tussen onderzoek doen en een van mijn favoriete vrijetijdsbestedingen, namelijk koken. Alles begint met een inspiratie, nieuwsgierigheid en een idee. Dan volgt de planning en de uitvoering en na (lang…) wachten kun je het resultaat proeven. Het blijft altijd spannend of het gelukt is en of het wel lekker is. Als het lekker is, dan smaakt het vaak ook naar meer! Zo niet, dan moet je het recept aanpassen, of crucialer, iets heel anders verzinnen...De weg naar een goed gelukt gerecht is, althans voor mij, minstens zo belangrijk: watertandend recepten zoeken en menu's samenstellen, op zoek gaan naar de juiste producten, lekker creatief combineren en (al of niet met succes) uitproberen. Dat kon ook in de voor mij nieuwe keuken van de wetenschap, en wel in een restaurant met een excellente ambiance. Verder is de diversiteit aan smaken, waar ik bij eten zo van houd, zeker ook terug te vinden in de verschillende hoofdstukken.Of kookkunsten gewaardeerd worden is vervolgens een kwestie van smaak, maar ook van kennis. De fijnproevers zullen zich op de details storten en boeren die het niet kennen zullen het niet eten, maar voor iedereen die aan tafel schuift: hopelijk is datgene wat in dit boekje geserveerd wordt smakelijk en levert het gespreksstof op voor het natafelen! Abbreviations and glossary & G L O S S A R Y AB BR EVI ATI ONS 23General IntroductionHistorical explorers discovered new land around the world, and with every journey more details have been added to global maps. For multiple sclerosis research, explorers of the 20 th century put vitamin D on the map, and from 2008 onwards, our research team in Maastricht has tried to add more details to this area. Today, vitamin D in multiple sclerosis is still an active area of research. Many reviews concentrate on the role of vitamin D in multiple sclerosis, illustrated by clinical and immunological studies. Also in this thesis two reviews elaborate on this topic. Therefore, the introduction to this thesis is restricted to the essential players, i.e. multiple sclerosis, its immune pathogenesis, and vitamin D, followed by the outline of the thesis.Multiple sclerosis (MS) is the most common disabling neurological disease among young people. Initial symptoms generally occur in the age of 20-40 years and MS affects women 2-3 times more often compared to men [1][2] . Currently, almost 1 in 1000 people suffers from MS in the Netherlands [3] . MS is characterized by inflammation and neurodegeneration of the central nervous system (CNS; brain and spinal cord). Though, it is still a matter of debate whether it is neurodegenerative or inflammatory from onset [1,4] . Most accepted, however, is the thought that inflammatory processes lead to damage of the fatty myelin sheaths covering the neuronal axons, which normally support fast transduction of signals, and this process is called demyelination. The inflammation can be accompanied by axonal injury and over time this result...

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Characterisation of vitamin D-related molecules and calcium-sensing receptor in human Fallopian tube during the menstrual cycle and in ectopic pregnancy

et al. 2016

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This is a prospective observational study that measures the expression of vitamin D (VD) metabolising and signalling molecules and Ca sensing receptor (CaSR) in human Fallopian tube (FT) during the menstrual cycle and ectopic pregnancy (EP). Fresh FTs were obtained during total abdominal hysterectomy at the follicular (n = 16) and midluteal (n = 16) phases. Specimens from remote and implantation sites as well as trophoblastic tissues were also freshly collected from each FT with EP (n = 10). All women had normal serum VD and ionised Ca. The expression of VD synthesising (CYP27B1) and catalysing (CYP24A1) enzymes, binding protein (VDBP), receptor (VDR), retinoid X receptor (RXR) and CaSR was measured by immunohistochemistry and quantitative RT-PCR. All molecules, except VDBP, were significantly increased (P < 0.05) in midluteal compared with follicular samples. Remote EP sites showed significantly (P < 0.05) lower expression of CYP27B1, CYP24A1, VDR and RXR and a higher expression of VDBP and CaSR (P < 0.05) compared with midluteal samples. Significant differences were observed by immunohistochemistry between implantation and remote sites from EP for all molecules, which were also localised in the trophoblastic tissues. In conclusion, VD and calcium are under cycle-dependent regulations within human FT and they appear to play a role in tubal biology through paracrine/autocrine mode of signalling. Furthermore, EP was associated with alterations in the expression of all the studied molecules by the tubal epithelium. Further studies are needed to explore the roles of VD in tubal biology and pathogenesis of EP.

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Cutting Edge: Progesterone Directly Upregulates Vitamin D Receptor Gene Expression for Efficient Regulation of T Cells by Calcitriol

Cited by 26 publications

References 27 publications

A Functional Relay from Progesterone to Vitamin D in the Immune System

A Functional Relay from Progesterone to Vitamin D in the Immune System

Mapping the effects of vitamin D in multiple sclerosis

Characterisation of vitamin D-related molecules and calcium-sensing receptor in human Fallopian tube during the menstrual cycle and in ectopic pregnancy

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