Cutting edge microfluidics: Xurography and a microwave

Speller, Nicholas C.; Morbioli, Giorgio Gianini; Cato, Michael E.; Cantrell, T.; Leydon, Erin M.; Schmidt, B. E.; Stockton, Amanda M.

doi:10.1016/j.snb.2019.04.004

Cited by 52 publications

(51 citation statements)

References 35 publications

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“…[30] The interest in this methodology increased in recent years since some authors have been successfully applied methods using commercial microwave ovens to achieve fast PDMS curing envisaging microfluidic applications. [31][32][33] The silicone used in this study is cross-linked by Ptcatalysed hydrosilylation reaction, that is, carried out at Si H bonds have an exponential increase when the temperature is raised from 55 C to 75 C; the reaction is completed in nearly 5 minutes, as reported by Bhattacharya and coworkers. [34] Therefore, it is reasonable to state that that PDMS crosslinking can be completed within 10 minutes, as observed in this study and that the process is accelerated by the heating effect provided by microwave irradiation.…”

Section: Silicone/pmma Blends Characterizationmentioning

confidence: 57%

Microwave‐assisted processing of silicone/PMMA blends for maxillofacial prostheses

Anjos

Revoredo

Galembeck

2020

Polymer Engineering & Sci

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Maxillofacial prostheses replace soft tissues that were lost due to disease or trauma, providing the restoration of the original anatomy and protecting the injured tissue. Silicone is the most widely used material, but the crosslinking process usually takes 24 hours to be completed. In this study, silicone/poly (methyl-methacrylate) blends were prepared at room temperature and assisted by microwave irradiation. The samples were characterized by confocal Raman microscopy and scanning electron microscopy/energy-dispersive X-ray spectroscopy. The microwave-assisted crosslinking is completed within 10 minutes and leads to better adhesion between silicone and PMMA than samples processed at room temperature. The methodology was adapted for the fabrication of prostheses for 50 patients with an average lifetime of 3 years, which is higher than the averages reported earlier in the literature (6-24 months).

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Section: Silicone/pmma Blends Characterizationmentioning

confidence: 57%

Microwave‐assisted processing of silicone/PMMA blends for maxillofacial prostheses

Anjos

Revoredo

Galembeck

2020

Polymer Engineering & Sci

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“…(C) Schematic view of the hot embossing process (Sahli et al, 2013). (D) Schematic of xurography fabrication process (Speller et al, 2019). (E) Examples of commercial rapid paper-based microfluidic devices (Yetisen et al, 2013).…”

Section: Technology For Loc Fabricationmentioning

confidence: 99%

“…(F) Lab-on-PCB integrating active control diluter (Moschou and Tserepi, 2017). 2D) (Speller et al, 2019) and paper-based methods ( Fig. xurography ( Fig.…”

Section: Technology For Loc Fabricationmentioning

confidence: 99%

Recent advances in lab-on-a-chip technologies for viral diagnosis

Zhu

Fohlerová

Pekárek

et al. 2020

Biosensors and Bioelectronics

190

146

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A B S T R A C TThe global risk of viral disease outbreaks emphasizes the need for rapid, accurate, and sensitive detection techniques to speed up diagnostics allowing early intervention. An emerging field of microfluidics also known as the lab-on-a-chip (LOC) or micro total analysis system includes a wide range of diagnostic devices. This review briefly covers both conventional and microfluidics-based techniques for rapid viral detection. We first describe conventional detection methods such as cell culturing, immunofluorescence or enzyme-linked immunosorbent assay (ELISA), or reverse transcription polymerase chain reaction (RT-PCR). These methods often have limited speed, sensitivity, or specificity and are performed with typically bulky equipment. Here, we discuss some of the LOC technologies that can overcome these demerits, highlighting the latest advances in LOC devices for viral disease diagnosis. We also discuss the fabrication of LOC systems to produce devices for performing either individual steps or virus detection in samples with the sample to answer method. The complete system consists of sample preparation, and ELISA and RT-PCR for viral-antibody and nucleic acid detection, respectively. Finally, we formulate our opinions on these areas for the future development of LOC systems for viral diagnostics.

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“…The incisions are made with a sintered tungsten alloy blade (Figure 5b,c) into the desired material. Xurography has been used to cut cyclo-olefin-based flow chambers to study microtubules dynamics under mechanical stress [25], cut omniphobic fluoroalkylated paper (R F paper) in the production of microfluidic paper-based analytical devices [26] and create moulds for soft-lithography [27]. Even though xurography can achieve good fidelity and reproducibility when cutting relatively thin (<200 µm) and rigid sheets of materials, the use of thick and soft materials (such as PDMS) is more challenging as the sheets deform during the cut process [24].…”

Section: Xurographymentioning

confidence: 99%

Low-Cost Microfabrication Tool Box

et al. 2020

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Microsystems are key enabling technologies, with applications found in almost every industrial field, including in vitro diagnostic, energy harvesting, automotive, telecommunication, drug screening, etc. Microsystems, such as microsensors and actuators, are typically made up of components below 1000 microns in size that can be manufactured at low unit cost through mass-production. Yet, their development for commercial or educational purposes has typically been limited to specialized laboratories in upper-income countries due to the initial investment costs associated with the microfabrication equipment and processes. However, recent technological advances have enabled the development of low-cost microfabrication tools. In this paper, we describe a range of low-cost approaches and equipment (below £1000), developed or adapted and implemented in our laboratories. We describe processes including photolithography, micromilling, 3D printing, xurography and screen-printing used for the microfabrication of structural and functional materials. The processes that can be used to shape a range of materials with sub-millimetre feature sizes are demonstrated here in the context of lab-on-chips, but they can be adapted for other applications. We anticipate that this paper, which will enable researchers to build a low-cost microfabrication toolbox in a wide range of settings, will spark a new interest in microsystems.

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Cutting edge microfluidics: Xurography and a microwave

Cited by 52 publications

References 35 publications

Microwave‐assisted processing of silicone/PMMA blends for maxillofacial prostheses

Microwave‐assisted processing of silicone/PMMA blends for maxillofacial prostheses

Recent advances in lab-on-a-chip technologies for viral diagnosis

Low-Cost Microfabrication Tool Box

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