Cutting edge issues in juvenile sclerosing cholangitis

Giorgio, Angelo Di; Vergani, Diego; Mieli‐Vergani, Giorgina

doi:10.1016/j.dld.2021.06.028

Cited by 6 publications

(3 citation statements)

References 102 publications

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“…Indeed, it has been stressed that PSC is rare in pediatrics, whereas sclerosing cholangitis is associated with strong autoimmune features [120]. In a retrospective cohort from the King's College Hospital, which included 83 children with autoimmune sclerosing cholangitis, female sex accounted for 42% of cases, while in a prospective cohort, which included 27 patients, female sex was present in 55% of cases [97].…”

Section: Sex Disparities In Autoimmune Liver Diseases In Pediatricsmentioning

confidence: 99%

Are Gender Differences Important for Autoimmune Liver Diseases?

Floreani,

Gabbia,

De Martin

2024

Life

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Gender Medicine has had an enormous expansion over the last ten years. Autoimmune liver diseases include several conditions, i.e., autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and conditions involving the liver or biliary tree overlapping with AIH, as well as IgG4-related disease. However, little is known about the impact of sex in the pathogenesis and natural history of these conditions. The purpose of this review is to provide an update of the gender disparities among the autoimmune liver diseases by reviewing the data published from 1999 to 2023. The epidemiology of these diseases has been changing over the last years, due to the amelioration of knowledge in their diagnosis, pathogenesis, and treatment. The clinical data collected so far support the existence of sex differences in the natural history of autoimmune liver diseases. Notably, their history could be longer than that which is now known, with problems being initiated even at a pediatric age. Moreover, gender disparity has been observed during the onset of complications related to end-stage liver disease, including cancer incidence. However, there is still an important debate among researchers about the impact of sex and the pathogenesis of these conditions. With this review, we would like to emphasize the urgency of basic science and clinical research to increase our understanding of the sex differences in autoimmune liver diseases.

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Section: Sex Disparities In Autoimmune Liver Diseases In Pediatricsmentioning

confidence: 99%

Are Gender Differences Important for Autoimmune Liver Diseases?

Floreani,

Gabbia,

De Martin

2024

Life

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“…UDCA from bear bile has been used in traditional Chinese medicine for hundreds of years to treat a range of diseases, including liver and intestinal disorders. In Western medicine, UDCA has been used for many years to treat liver diseases, especially primary biliary cholangitis, and as a bile acid replacement therapy to reduce bile acid toxicity in patients with deficient bile acid synthesis, gallstone dissolution, and digestive diseases[ 67 , 68 ]. Its potential for the prevention of primary sclerosing cholangitis and IBD has also been investigated.…”

Section: Treatment and Management Of Badmentioning

confidence: 99%

Diagnosis and treatment of post-cholecystectomy diarrhoea

Huang,

Xiao

et al. 2023

World J Gastrointest Surg

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The incidence of cholecystitis is relatively high in developed countries and may usually be attributed to gallstones, the treatment for which involves complete surgical removal of the gallbladder (cholecystectomy). Bile acids produced following cholecystectomy continue to flow into the duodenum but are poorly absorbed by the colon. Excessive bile acids in the colon stimulate mucosal secretion of water and electrolytes leading, in severe cases, to diarrhoea. Bile acid diarrhoea (BAD) is difficult to diagnose, requiring a comprehensive medical history and physical examination in combination with laboratory evaluation. The current work reviews the diagnosis and treatment of BAD following cholecystectomy.

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“… 2 , 11 Overlap syndrome shares these features described in ASC but historically affects older children/adults. 11 , 12 Ultimately true validated definitions for both conditions do not exist, and terminology and practice continue to evolve.…”

Section: Introductionmentioning

confidence: 99%

Biliary disease progression in childhood onset autoimmune liver disease: A 30-year follow-up into adulthood

Warner,

Rajanayagam,

Russell

et al. 2024

JHEP Reports

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Cutting edge issues in juvenile sclerosing cholangitis

Cited by 6 publications

References 102 publications

Are Gender Differences Important for Autoimmune Liver Diseases?

Are Gender Differences Important for Autoimmune Liver Diseases?

Diagnosis and treatment of post-cholecystectomy diarrhoea

Biliary disease progression in childhood onset autoimmune liver disease: A 30-year follow-up into adulthood

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