Cutting Edge: Identification of Neutrophil PGLYRP1 as a Ligand for TREM-1

Read, Christine B.; Kuijper, Joseph L.; Hjorth, Siv A.; Heipel, Mark; Tang, Xiaoting; Fleetwood, Andrew J.; Dantzler, Jeffrey L.; Grell, S. N.; Kastrup, Jesper; Wang, Camilla; Brandt, Cameron S.; Hansen, Anker Jón; Wagtmann, Nicolai; Xu, Wenfeng; Stennicke, Vibeke W.

doi:10.4049/jimmunol.1402303

Cited by 124 publications

(124 citation statements)

References 16 publications

Supporting

Mentioning

120

Contrasting

Unclassified

Order By: Relevance

“…Of particular note is PGLYRP-1, which is expressed primarily in neutrophil granules, and was recently identified by Read et al (2015) as a ligand for the orphan neutrophil and monocyte/macrophage Ig superfamily receptor TREM-1, which augments inflammatory and innate immune responses triggered by exogenous pathogens by stimulating release of pro-inflammatory mediators (Ford and McVicar, 2009). Of particular interest, PGLYP-1 acts either independently or in combination with PGN to promote signaling at this receptor.…”

Section: Discussionmentioning

confidence: 99%

Immunobiotic Lactobacillus administered post-exposure averts the lethal sequelae of respiratory virus infection

Percopo¹,

Rice²,

Brenner³

et al. 2015

Antiviral Research

View full text Add to dashboard Cite

We reported previously that priming of the respiratory tract with immunobiotic Lactobacillus prior to virus challenge protects mice against subsequent lethal infection with pneumonia virus of mice (PVM). We present here the results of gene microarray which document differential expression of proinflammatory mediators in response to PVM infection alone and those suppressed in response to Lactobacillus plantarum. We also demonstrate for the first time that intranasal inoculation with live or heat-inactivated L. plantarum or Lactobacillus reuteri promotes full survival from PVM infection when administered within 24 h after virus challenge. Survival in response to L. plantarum administered after virus challenge is associated with suppression of proinflammatory cytokines, limited virus recovery, and diminished neutrophil recruitment to lung tissue and airways. Utilizing this post-virus challenge protocol, we found that protective responses elicited by L. plantarum at the respiratory tract were distinct from those at the gastrointestinal mucosa, as mice devoid of the anti-inflammatory cytokine, interleukin (IL)-10, exhibit survival and inflammatory responses that are indistinguishable from those of their wild-type counterparts. Finally, although L. plantarum interacts specifically with pattern recognition receptors TLR2 and NOD2, the respective gene-deleted mice were fully protected against lethal PVM infection by L. plantarum, as are mice devoid of type I interferon receptors. Taken together, L. plantarum is a versatile and flexible agent that is capable of averting the lethal sequelae of severe respiratory infection both prior to and post-virus challenge via complex and potentially redundant mechanisms.

show abstract

Section: Discussionmentioning

confidence: 99%

Immunobiotic Lactobacillus administered post-exposure averts the lethal sequelae of respiratory virus infection

Percopo¹,

Rice²,

Brenner³

et al. 2015

Antiviral Research

View full text Add to dashboard Cite

show abstract

“…Its silencing markedly reduces activation of the key cytokine genes under the effect of LPS [28] . Read et al [24] showed that Tag7 is able to interact with the TREM-1 receptor, inducing the secretion of proinflammatory cytokines. Here, we have shown an activation of the proinflammatory cytokine genes in response to the Tag7 stimulation of TREM-1.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it has been shown by Read et al [24] that Tag7 (PGLYRP1) in the complex with bacterial peptidoglycan or in a multimeric form is capable of binding to TREM-1 during immune responses triggered by bacteria. These authors also demonstrated the direct binding of these 2 proteins.…”

Section: Treatment With Tag7 Leads To Activation Of Monocytes and Conmentioning

confidence: 99%

Innate Immunity Protein Tag7 Induces 3 Distinct Populations of Cytotoxic Cells That Use Different Mechanisms to Exhibit Their Antitumor Activity on Human Leukocyte Antigen-Deficient Cancer Cells

et al. 2017

View full text Add to dashboard Cite

The search for new immune response mechanisms capable of controlling immune-evasive tumor cells devoid of the MHC antigen is a challenging task for immunologists. In this study, we found that the treatment of human peripheral blood lymphocytes with the innate immunity protein Tag7 (PGRP-S, PGLYRP1) induces differentiation of the populations of NK (natural killer) cells and CD8+ and CD4+ T lymphocytes that are cytotoxic for human leukocyte antigen-negative tumor cells. These populations employ different mechanisms of tumor cell lysis (based on the release of granzymes in the case of NK cells and on the FasL-Fas interaction in the case of CD8+ and CD4+ T lymphocytes) and induce different death pathways (apoptosis or necroptosis) in tumor cells. An analysis of genes activated in leukocyte populations after Tag7 treatment and experiments with specific inhibitors have shown that the TREM-1 receptor expressed on the monocyte cell surface is essential for activation of cytotoxic activity. Overall, the results of this study provide evidence for a novel role of the Tag7 protein in the immune response.

show abstract

“…Direct interaction between TREM-1 and HMGB1 was demonstrated in a murine model through a combination of immunoprecipitation, chemical cross-linking of proteins and surface plasmon resonance techniques, indicating binding capability with TREM-1 and supporting HMGB1 as an activating ligand [14]. Peptidoglycan recognition protein 1, when complexed with bacterially derived peptidoglycan, has also been identified as a ligand for TREM-1 [15]. This pathway provides a mechanism for activation of TREM-1 by neutrophils, thereby enhancing cytokine production in the local innate immune response.…”

Section: Molecular Characteristics and Expression Of The Trem Receptomentioning

confidence: 99%

“…The activity of HMGB1 in TREM signaling, whether an agonist or antagonist, remains unresolved. Additionally, a complex between peptidoglycan recognition protein 1 and bacterially derived peptidoglycan has been identified as a potent ligand capable of binding and activating TREM-1 [15]. This offers a mechanism for activation of TREM-1 by neutrophils in sepsis.…”

Section: Expert Commentary and Five-year Viewmentioning

confidence: 99%

Chronic inflammation and cancer: emerging roles of triggering receptors expressed on myeloid cells

Nguyen

Berim

Agrawal

2015

Expert Review of Clinical Immunology

View full text Add to dashboard Cite

Summary Inflammation is tightly regulated by a vast system that is intricately interconnected with innate immunity. Aberrations in expression or signaling, such as in innate immune receptors, can create excessive inflammation and, when chronic, often promote oncogenesis. The triggering receptor expressed on myeloid cells (TREM) receptor family has been characterized as a major player in the amplification and signaling of the inflammatory response. In a number of chronic inflammatory conditions and malignancies, TREM has been implicated in disease severity and progression. In this article, the current understanding of TREM function in pre-malignant, malignant and chronic inflammatory conditions is critically reviewed. The potential for therapeutic application is also discussed.

show abstract

Cutting Edge: Identification of Neutrophil PGLYRP1 as a Ligand for TREM-1

Cited by 124 publications

References 16 publications

Immunobiotic Lactobacillus administered post-exposure averts the lethal sequelae of respiratory virus infection

Immunobiotic Lactobacillus administered post-exposure averts the lethal sequelae of respiratory virus infection

Innate Immunity Protein Tag7 Induces 3 Distinct Populations of Cytotoxic Cells That Use Different Mechanisms to Exhibit Their Antitumor Activity on Human Leukocyte Antigen-Deficient Cancer Cells

Chronic inflammation and cancer: emerging roles of triggering receptors expressed on myeloid cells

Contact Info

Product

Resources

About