Cutting Edge: Human CD4+CD25+ T Cells Restrain the Maturation and Antigen-Presenting Function of Dendritic Cells

Abstract

The characteristics and functions of CD4+CD25+ regulatory cells have been well defined in murine and human systems. However, the interaction between CD4+CD25+ T cells and dendritic cells (DC) remains unclear. In this study, we examined the effect of human CD4+CD25+ T cells on maturation and function of monocyte-derived DC. We show that regulatory T cells render the DC inefficient as APCs despite prestimulation with CD40 ligand. This effect was marginally reverted by neutralizing Abs to TGF-β. There was an increased IL-10 secretion and reduced expression of costimulatory molecules in DC. Thus, in addition to direct suppressor effect on CD4+ T cells, regulatory T cells may modulate the immune response through DC.

Alloreactive regulatory T cells generated with retinoic acid prevent skin allograft rejection

“…This idea is reinforced by the observation that in vitro suppression was abrogated in the presence of APCP, a CD73-specific inhibitor (data not shown). Another well-known suppressive function of Treg cells includes the control of DC maturation and activation by CTLA-4 and LAG-3 expression [62][63][64][65][66]. The high expression of these molecules by RA-iTreg cells supports the notion that these cells may regulate the immune response by also suppressing DC function.…”

Inhibition of murine γδ lymphocyte expansion and effector function by regulatory αβ T cells is cell‐contact‐dependent and sensitive to GITR modulation

“…CD4 1 CD25 1 ab T cells are well known for their ability to control the activity of several immune cell populations in vitro and in vivo, including effector CD4 1 CD25 À and CD8 1 ab T cells [13], NK [14] and NKT cells [15], B cells [16], DC [17], and monocytes/macrophages [18]. As a result, CD4 1 CD25 1 ab T cells, and particularly those that develop in the thymus through a Foxp3-dependent genetic program [19,20], so-called ''naturally occurring'' Treg (nTreg), are pivotal to maintaining immune homeostasis and preventing inflammatory and autoimmune diseases [21].…”

“…Furthermore, several reports have demonstrated the crucial contributions of gd T cells to the reservoirs of such cytokines in the context of anti-tumor immunity [8], immune responses to infection [9], and autoimmunity [9,10]. While these data highlight the importance of understanding how the [17], and monocytes/macrophages [18]. As a result, CD4 1 CD25 1 ab T cells, and particularly those that develop in the thymus through a Foxp3-dependent genetic program [19,20], so-called ''naturally occurring '' Treg (nTreg), are pivotal to maintaining immune homeostasis and preventing inflammatory and autoimmune diseases [21].…”

Localisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer

“…These observations indicated that T regs play important roles in immunological homeostasis. Although the mechanisms of suppression by T regs are still unclear, it has been reported that T regs can inhibit the function of effector T cells directly through cell-to-cell contact or indirectly via the secretion of immune-suppressive cytokines, and also suppress the Agpresenting function of dendritic or NK cells (Dieckmann et al, 2002;Misra et al, 2004;Earle et al, 2005;Longhi et al, 2006;Smyth et al, 2006).…”