1998
DOI: 10.4049/jimmunol.160.2.540
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Cutting Edge: A Critical, Invariant Chain-Independent Role for H2-M in Antigen Presentation

Abstract: Antigen presentation by MHC class II (class II) is facilitated by the accessory molecules, invariant chain (Ii) and H2-M. Ii associates with class II during biosynthesis and promotes transport of class II to Ag-loading compartments. One function of H2-M is the removal of Ii fragments from MHC class II. We have previously demonstrated that Ii-deficient mice, unlike class II-deficient mice, are resistant to L. major infection. In the present study, we found that H2-M-deficient (H2-M0) mice were susceptible to pr… Show more

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Cited by 15 publications
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