Cutoff values for central obesity in Chinese based on mesenteric fat thickness

Ko, G. T. C.; Liu, Kin-Hung; So, Wing‐Yee; Tong, Peter C.Y.; Ma, Rong; Ozaki, Risa; Kong, Alice Pik‐Shan; Yeung, Chi K; Yang, Xilin; Ho, Chung-Shun; Chu, Winnie Chiu-Wing; Chan, Juliana C.N.

doi:10.1016/j.clnu.2009.05.017

Cited by 19 publications

(13 citation statements)

References 27 publications

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“…The different observations between our and other groups may result from changes in correlations of WC and %TF with increasing age [38]. Recently, data from Shanghai [39] and Hong Kong [40] indicated that the optimal WC cutoffs were 82 cm for abdominal obesity and 75 cm for mesenteric fat thickness among Chinese women, respectively. In this study, the WC cutoff was 80 cm for central obesity, which is similar.…”

Section: Discussionmentioning

confidence: 70%

Association of central adiposity with prediabetes and decreased insulin sensitivity in rural Chinese normal-weight and overweight women

Venners

Zhang

et al. 2010

Metabolism

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Objective-This study investigated whether high central adiposity was associated with pre-diabetes and decreased insulin sensitivity (IS) in both normal weight (BMI < 23 kg/m 2 ) and overweight (BMI ≥ 23) rural Chinese women.Methods-Adipose variables measured by dual energy X-ray absorptiometry (DEXA) (Percent body fat -%BF, percent lower body fat -%LF and percent trunk fat -%TF) and general adipose variables (BMI and waist circumference -WC) were used for examining the association of adiposity with pre-diabetes among 4,071 rural Chinese females aged 20-60 years. Also, the association of adiposity with IS was tested in both normal and overweight women with normal glucose tolerance (NGT).Results-BMI was highly correlated with %BF and WC, but weakly correlated with %LF and % TF. Both high %TF (top quartile of %TF) and low %LF (lower three quartiles of %LF) were associated with higher prevalence of pre-diabetes in both normal and overweight women. Compared to normal weight women in low %TF, the odds of pre-diabetes were similarly increased for women with high %TF regardless of whether they were overweight (OR (95% CI) = 1.6 (1.3-2.0)) or not (OR (95% CI) = 1.5 (1.2-2.0)). Similarly, among 3,280 women with NGT, high %TF was associated with increased fasting insulin, 2H-OGTT insulin and HOMA-IR regardless of normal or overweight.Conclusions-Among relatively lean, rural Chinese women, high %TF was associated with increased odds of pre-diabetes and lower IS regardless of normal or overweight.

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Section: Discussionmentioning

confidence: 70%

Association of central adiposity with prediabetes and decreased insulin sensitivity in rural Chinese normal-weight and overweight women

Venners

Zhang

et al. 2010

Metabolism

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“…20,21 Mesenteric adipose tissue inflammation plays a pathogenic role in NAFLD. First, the incidence of NAFLD dramatically increases as MAT thickens, 22,23 and Bergman et al suggest that MAT is a better predictor of insulin sensitivity than other depots of VAT. 7 Next, in inflamed MAT, the cytokines and lipid decomposition products drained to portal vein are elevated, promoting the damage of liver.…”

Section: Discussionmentioning

confidence: 99%

Mesenteric adipose tissue B lymphocytes promote local and hepatic inflammation in non‐alcoholic fatty liver disease mice

Tan

et al. 2019

J Cellular Molecular Medi

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Mesenteric adipose tissue (MAT) inflammation is associated with non‐alcoholic fatty liver disease (NAFLD), and immune cells play pivotal roles in the inflammation of adipose tissue. Here, we investigated the roles of MAT B lymphocytes in NAFLD. Mice fed with high‐fat diet (HFD) and normal diet (ND) were killed in time gradients (4, 8 and 12 weeks). Compared with ND‐fed mice, intra‐hepatic CD45 + CD19 + B lymphocytes increased after 4 weeks ( P < 0.01) of HFD feeding, and lasted until the 12th week, infiltrated earlier than CD45 + CD3 + T lymphocytes and CD45 + F4/80 + macrophages. The mRNA expression of tumour necrosis factor (TNF)‐α, interleukin (IL)‐6 and monocyte chemotactic protein (MCP)‐1 decreased in MAT of B null HFD‐fed mice compared to that in wild‐type HFD‐fed mice, along with lesser macrophages. Mesenteric adipose tissue B cells from HFD‐fed mice promoted macrophage differentiation to type‐Ι macrophages and expression of pro‐inflammatory cytokines in vitro. Macrophages pre‐treated with MAT B cells from HFD‐fed mice showed elevated mRNA expression of IL‐6 and TNF‐α and declined IL‐10 levels in adipocytes compared to ND MAT B cell pre‐treated macrophages. Besides, internal near‐infrared scanning and external transwell assay showed that HFD MAT B cells migrated to the liver more than ND MAT B cells. High‐fat diet MAT B cells induced higher MCP‐1 and lower IL‐10 expression in primary hepatocytes compared to ND MAT B cells in co‐culture experiment. These data indicate that B lymphocytes infiltrate early in MAT during the development of NAFLD, which may not only promote MAT inflammation by regulating macrophages but also migrate to the liver and induce hepatocytes inflammation.

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“…Ko et al 20. determined that in a Chinese population, WC of 84.6 cm in men and 75.7 cm in women were the optimal cut‐off values to predict high mesenteric fat thickness with ROC analysis.…”

Section: Discussionmentioning

confidence: 99%

Optimal cut‐off levels of obesity indices by different definitions of metabolic syndrome in a southeast rural Chinese population

Pan

Wang

et al. 2016

J of Diabetes Invest

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Aims/IntroductionThe aim of the present study was to compare the cut‐off values and prediction effect of different obesity indices by different definitions of metabolic syndrome (MetS) in Zhejiang Province of China.Materials and MethodsWe carried out a cross‐sectional survey of 10,100 individuals (age 40 years and older) in Jiashan, Zhejiang Province. Receiver operating characteristic analysis was used to examine discrimination and find optimal cut off values of waist circumference (WC), body mass index (BMI), waist‐to‐hip ratio (WHR) and waist‐to‐height ratio (WHtR) to predict two or more non‐adipose components of MetS by The National Cholesterol Education Program Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III) definition modified by the Asia–Pacific region criteria, International Diabetes Federation definition for the Chinese population and Chinese Diabetes Society definitions of MetS.ResultsThe age‐standardized prevalence of MetS was 23.78% vs 28.76% vs 19.37% by The National Cholesterol Education Program Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III), International Diabetes Federation and Chinese Diabetes Society definitions, respectively. Cut‐off values of BMI were approximately 24 kg/m2 both in men and women by three definitions; the average cut‐off values of WC, WHR and WHtR were 83 cm in men vs 81 cm in women, 0.89 in men vs 0.86 in women and 0.50 in men vs 0.51 in women, respectively. The area under receiver operating characteristic curve of BMI was larger than WC both in men and women (P < 0.05); in women, the area under receiver operating characteristic curve of WHtR was larger than WC, and WHR was smaller.ConclusionsMetS is prevalent in Zhejiang Province of China, especially in the female population. BMI and WHtR might be more useful than WC and WHR for predicting two or more non‐adipose components of MetS.

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Cutoff values for central obesity in Chinese based on mesenteric fat thickness

Cited by 19 publications

References 27 publications

Association of central adiposity with prediabetes and decreased insulin sensitivity in rural Chinese normal-weight and overweight women

Association of central adiposity with prediabetes and decreased insulin sensitivity in rural Chinese normal-weight and overweight women

Mesenteric adipose tissue B lymphocytes promote local and hepatic inflammation in non‐alcoholic fatty liver disease mice

Optimal cut‐off levels of obesity indices by different definitions of metabolic syndrome in a southeast rural Chinese population

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