Cutoff and Target Values for Intra-Abdominal Fat Area for Prevention of Metabolic Disorders in Pre- and Post-Menopausal Obese Women Before and After Weight Reduction

Shigematsu, Ryosuke; Okura, Tomohiro; Kumagai, Syuzo; Kitagawa, Yuko; Hiyama, Teruo; Sasaki, Haruka; Amagai, Hitoshi; Tanaka, Kiyoji

doi:10.1253/circj.70.110

Cited by 7 publications

(15 citation statements)

References 24 publications

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“…[23][24][25] In the present study, 75 cm 2 of VFA at L4 and 87.5 cm 2 at L1 level were the optimal cut-off thresholds for discrimination of MetS risk. Shigematsu et al also reported similar results to ours; their cut-off values for obesity-related metabolic disorders in Japanese obese women were 80 cm 2 in the premenopausal and 110 cm 2 in the postmenopausal.…”

Section: Discussionmentioning

confidence: 50%

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Evaluation of Metabolic Syndrome Risk in Korean Premenopausal Women Not Waist Circumference but Visceral Fat

Hyun

Kim

Jang

et al. 2008

Circ J

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simple anthropometric measurement, such as waist circumference (WC) or waist to hip ratio (WHR), is widely used in clinical practice as a surrogate for central obesity in order to assess health status. 1,2 However, for a given WC, body fat distribution differs significantly according to gender, menopausal status, age, and so forth. 3,4 Particularly in premenopausal women, subcutaneous fat is relatively predominant over abdominal visceral fats, 5 and so using WC to evaluate visceral obesity could underestimate metabolic disorders.Metabolic syndrome (MetS) is a major public health challenge because of its implications in the increased risk of type 2 diabetes and cardiovascular disease (CVD). 6,7 During the past decade, various sets of diagnostic criteria for MetS have been proposed [8][9][10][11] and all share the major metabolic risk factors (RF) such as abdominal obesity, insulin resistance/glucose intolerance, dyslipidemia and hypertension. However, there are 2 major differences in the organization of the criteria and the emphasis on excessive adiposity. [8][9][10][11] Thus, discrepant cases are often reported in studies of the prevalence of MetS, or in the subjects' characteristics classified to MetS, depending on the definition used. 12-14 Currently, the International Diabetes Federation (IDF) criteria, 11 which define WC as an obligatory factor for diagnosing MetS, are under discussion for thier inability to detect metabolically abnormal but non-obese individuals. 12,15 In addition, a WHO expert consultation addressed the fact that Asians generally have a higher percentage of body fat and show greater abdominal obesity at a lower body mass index (BMI) than Caucasians. 16 The consultation also identified an additional trigger point for public health action or clinical intervention as being 23 kg/m 2 BMI because the relative risk for type 2 diabetes or CVD in Asian populations is substantial, even below 25 kg/m 2 BMI.Therefore, in order to evaluate the risk of MetS in premenopausal Asian women, the present study aimed to (a) elucidate the best marker of central obesity among the obesity-related anthropometric indices including computed tomography (CT) results, (b) define the optimal cut-off point of visceral fat area (VFA) in premenopausal women and (c) examine whether or not the WC derived from the cut-off point of the VFA can also reflect the features of MetS, particularly in subjects with BMI ≥23 kg/m 2 . J 2008; 72: 1308 -1315 (Received November 9, 2007 revised manuscript received March 12, 2008; accepted April 4, 2008 Background In clinical practice, using the patient's waist circumference (WC) to evaluate visceral obesity may underestimate disorders with a metabolic origin. This study examined whether or not the WC derived from the cut-off point of the visceral fat area (VFA) can reflect the features of metabolic syndrome (MetS) in premenopausal women. Circ Methods and ResultsComputed tomography-scanned VFA, MetS components and the concentrations of highsensitivity C-reactive protein (CRP) and adipone...

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Section: Discussionmentioning

confidence: 50%

“…Shigematsu et al also reported similar results to ours; their cut-off values for obesity-related metabolic disorders in Japanese obese women were 80 cm 2 in the premenopausal and 110 cm 2 in the postmenopausal. 24 Those results indicate that in premenopausal women relatively small amount of VFA has a detrimental effect on MetS risk.…”

Section: Discussionmentioning

confidence: 92%

Evaluation of Metabolic Syndrome Risk in Korean Premenopausal Women Not Waist Circumference but Visceral Fat

Hyun

Kim

Jang

et al. 2008

Circ J

View full text Add to dashboard Cite

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“…The cutoff point of metabolic disorders with the best equilibrium was reported to be 80 cm 2 for Japanese premenopausal women and 110 cm 2 for postmenopausal women [15]. VFA cutoff values yielding an 80% sensitivity for the detection of multiple risk factors of metabolic syndrome were 86.4 cm 2 for Japanese men under the age of 40 years and 103.9 cm 2 for those over the age of 40 years [16].…”

Section: Discussionmentioning

confidence: 99%

Visceral Fat Level Is an Independent Risk Factor for Cardiovascular Mortality in Hemodialysis Patients

et al. 2014

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Background: Obesity is an independent risk factor for morbidity and mortality in cardiovascular diseases not only in the general population, but also in hemodialysis (HD) patients. We previously reported that an increased visceral fat area (VFA) determined using computed tomography (CT) scans was associated with atherosclerosis in HD patients. However, whether a high VFA is associated with increased cardiovascular mortality in HD patients remains unknown. Therefore, we investigated the relationship between VFA and prognosis in HD patients. Methods: VFA was estimated in 126 patients on maintenance HD using CT scans. These patients were followed for 60 months. Results: Kaplan-Meier analysis revealed that the cardiovascular survival rate was significantly lower in the high-VFA group, with a VFA of 71.5 cm² or greater, than in the low-VFA group, with a VFA of less than 71.5cm². In univariate Cox proportional hazards analyses, age, albumin, low-density lipoprotein cholesterol, cardio-thoracic ratio and VFA above 71.5 cm² were significantly correlated with cardiovascular deaths. In multivariate analyses testing these factors as dependent variables, VFA above 71.5 cm² was estimated to be an independent predictor of cardiovascular deaths. Conclusion: These results suggest that an increased VFA is a stronger risk factor for cardiovascular deaths in HD patients. Measuring VFA may be recommended for predicting the risk of cardiovascular diseases in HD patients.

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“…A total of 210 healthy Japanese adults (105 men and 105 women, aged 35–60 years) with large visceral fat areas (80·2–187·8 cm 2 ) were enrolled for the study. The cut-off value of the visceral fat area for the enrolment was set to 80·0 cm 2 in accordance with a study conducted in Japan ( 13 ) , in which the value has been suggested as appropriate when pre-menopausal women are included in the study group. Those with serious disorders, including internal organ diseases, diabetes and hypersensitivity to dairy products, were excluded.…”

Section: Methodsmentioning

confidence: 99%

Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomised controlled trial

et al. 2013

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Consumption of fermented milk (FM) containing a probiotic, Lactobacillus gasseri SBT2055 (LG2055), previously showed a reduction in abdominal adiposity in a randomised controlled trial (RCT) using FM with 10 8 colony-forming units (cfu) of LG2055/g. However, whether the effectiveness is observed at lower concentrations, the recommended minimum or intermediate levels of probiotics (10 6 or 10 7 cfu/g, respectively), remains to be examined. A multi-centre, double-blind, parallel-group RCT was conducted using 210 healthy Japanese adults with large visceral fat areas (80·2 -187·8 cm 2 ). They were balanced for their baseline characteristics and randomly assigned to three groups receiving FM containing 10 7 , 10 6 or 0 (control) cfu LG2055/g of FM, and were asked to consume 200 g FM/d for 12 weeks. Abdominal visceral fat areas, which were determined by computed tomography, at week 12, changed from baseline by an average of 28·5 % (95 % CI 211·9, 2 5·1; P,0·01) in the 10 7 dose group, and by 2 8·2 % (95 % CI 210·8, 2 5·7; P, 0·01) in the 10 6 dose group. Other measures including BMI, waist and hip circumferences, and body fat mass were also significantly decreased from baseline at week 12 in both groups; interestingly, the cessation of taking FM for 4 weeks attenuated these effects. In the control group, none of these parameters significantly decreased from baseline. These findings demonstrate that consumption of LG2055 at doses as low as the order of 10 8 cfu/d exhibited a significant lowering effect on abdominal adiposity, and suggest that constant consumption might be needed to maintain the effect.

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Cutoff and Target Values for Intra-Abdominal Fat Area for Prevention of Metabolic Disorders in Pre- and Post-Menopausal Obese Women Before and After Weight Reduction

Cited by 7 publications

References 24 publications

Evaluation of Metabolic Syndrome Risk in Korean Premenopausal Women Not Waist Circumference but Visceral Fat

Evaluation of Metabolic Syndrome Risk in Korean Premenopausal Women Not Waist Circumference but Visceral Fat

Visceral Fat Level Is an Independent Risk Factor for Cardiovascular Mortality in Hemodialysis Patients

Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomised controlled trial

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