Cutis verticis gyrata

Walia, Rama; Bhansali, Anil

doi:10.1136/bcr.01.2011.3763

Cited by 6 publications

(8 citation statements)

References 3 publications

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“…In patients with acquired CVG, dermal collagen thickening and hypertrophy of the sebaceous structures (as in acromegaly), inflammation and edema, and, in some cases, malignant conditions (leukemia and sarcoma) are observed on pathologic review. [2][3][4] Irrespective of the underlying cause, the galea aponeurotica limits the soft tissue expansion and/or overgrowth of the scalp, which in turn leads to the unique and characteristic cerebriform pattern. Spontaneous resolution of acquired CVG can occur with treatment of the underlying medical cause; however, in many patients, the cutaneous changes are permanent.…”

Section: Discussionmentioning

confidence: 99%

“…1 CVG is an uncommon and typically innocuous dermatologic condition that occurs either in isolation (ie, primary essential CVG) or in association with a number of medical conditions (ie, primary nonessential or secondary/acquired CVG). 2 On histopathologic examination, the appearance of CVG is variable and depends on the underlying etiology. In isolated cases of CVG, dermal biopsy may reveal normal skin architecture.…”

Section: Discussionmentioning

confidence: 99%

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Cutis Verticis Gyrata in Association With Vemurafenib and Whole-Brain Radiotherapy

Harding

Barker

Wolchok

et al. 2014

JCO

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Case Report 1A 33-year-old man presented to an outside hospital with a 2-month history of lower back pain, fever, chills, and anorexia. Physical examination revealed subcutaneous nodules on the chest, abdomen, and back. Cross-sectional imaging demonstrated multiple masses throughout the paraspinal tissue, vertebrae, liver, and subcutis. A magnetic resonance imaging scan of the brain showed four brain metastases ranging from 2 to 12 mm in size. An excisional biopsy of a subcutaneous lesion revealed metastatic melanoma characterized by a BRAF V600E mutation.The patient initiated external-beam whole-brain radiotherapy (WBRT, 30 Gy over 10 daily fractions with 6 MV photons) and vemurafenib at a dose of 960 mg orally twice per day. After seven of 10 fractions of WBRT (21 Gy), the patient developed pain and erythema of the ears and scalp, resulting in a diagnosis of grade 2 radiation dermatitis. The patient temporarily stopped WBRT and received topical emollients. Vemurafenib was continued without a dose reduction. After slight improvement in his symptoms, WBRT was reinitiated to complete the 10 fractions. The patient subsequently noted recurrence and worsening of his symptoms, which reached their maximum severity approximately 3 weeks after completion of WBRT.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cutis Verticis Gyrata in Association With Vemurafenib and Whole-Brain Radiotherapy

Harding

Barker

Wolchok

et al. 2014

JCO

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“…Histological hypertrophy of sebaceous structures is seen with without collagen thickening. 7 Prevalence of CVG in males is 1 in 100 000 and 0.026 in 100 000 in females. 6 We present a case of primary essential CVG in a male patient without underlying medical conditions.…”

Section: Introductionmentioning

confidence: 98%

Hyaloronidase as a Treatment for Cutis Verticis Gyrata

Chaghouri¹,

2021

Plastic Surgery Case Studies

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A unique case of patient with primary essential CVG is presented. The patient has no underlying medical conditions. A series of hyaluronidase injections spaced out in 6 week intervals was injected into the subcutaneous tissues overlying the scalp deformities. The end result after 3 sessions of injections demonstrated significant improvement which has been maintained over the 12 month follow up period. This is the first case report of the successful use of hyaluronidase injections to treat CVG in Canada.

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“…CVG is rare entity with estimated prevalence of 1 in 100,000 and is more common in males than females (5 to 6:1) [1][2][3]. CVG was classified into primary and secondary form by Polan and Butterworth in 1953 and Garden and Robinson further improved the classification by dividing primary form into primary essential and primary nonessential.…”

Section: Introductionmentioning

confidence: 99%