Cutavirus Infection in Primary Cutaneous B- and T-Cell Lymphoma

Kreuter, Alexander; Nasserani, Nima; Tigges, Christian; Oellig, Frank; Silling, Steffi; Akgül, Baki; Wieland, Ulrike

doi:10.1001/jamadermatol.2018.1628

Cited by 15 publications

(21 citation statements)

References 5 publications

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“…CuV has already gained much interest due to its association with cutaneous T-cell lymphoma, despite being discovered only in 2016. It has been predominantly searched for in skin cancers [ 4 , 20 , 21 , 22 ], however, nothing is known of its acute infections. No respiratory or stool samples have been analyzed for its prevalence or to characterize its possible symptoms in acute infections.…”

Section: Discussionmentioning

confidence: 99%

“…CuV has been more widely studied in skin samples than in stool or respiratory samples. So far, CuV DNA has been detected in skin biopsies of CTCL, melanoma and transplant patients with prevalences between 1.1–16% [ 4 , 21 , 22 , 23 ], but not in those of healthy subjects [ 4 , 21 ]. However, viral DNA has surprisingly been found in skin surface swabs of healthy adults (9/237, 3.8%) and of HIV-positive men (35/205, 17.1%) [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Its prevalence in stool has hitherto not been reported since the original discovery, which conveyed a low prevalence (1–2%) in Brazilian and Botswanan diarrheic children [ 4 ]. Excitingly, dermal CuV DNA is documented to be associated with cutaneous T-cell lymphoma (CTCL) [ 20 , 21 , 22 ]. It has also been detected in skin biopsies of melanoma and organ transplant patients, but not in those of healthy subjects [ 21 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Human Protoparvovirus DNA and IgG in Children and Adults with and without Respiratory or Gastrointestinal Infections

Mohanraj

Jokinen

Thapa

et al. 2021

Viruses

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Three human protoparvoviruses, bufavirus (BuV), tusavirus (TuV) and cutavirus (CuV), have recently been discovered in diarrheal stool. BuV has been associated with diarrhea and CuV with cutaneous T-cell lymphoma, but there are hardly any data for TuV or CuV in stool or respiratory samples. Hence, using qPCR and IgG enzyme immunoassays, we analyzed 1072 stool, 316 respiratory and 445 serum or plasma samples from 1098 patients with and without gastroenteritis (GE) or respiratory-tract infections (RTI) from Finland, Latvia and Malawi. The overall CuV-DNA prevalences in stool samples ranged between 0–6.1% among our six patient cohorts. In Finland, CuV DNA was significantly more prevalent in GE patients above rather than below 60 years of age (5.1% vs 0.2%). CuV DNA was more prevalent in stools among Latvian and Malawian children compared with Finnish children. In 10/11 CuV DNA-positive adults and 4/6 CuV DNA-positive children with GE, no known causal pathogens were detected. Interestingly, for the first time, CuV DNA was observed in two nasopharyngeal aspirates from children with RTI and the rare TuV in diarrheal stools of two adults. Our results provide new insights on the occurrence of human protoparvoviruses in GE and RTI in different countries.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Human Protoparvovirus DNA and IgG in Children and Adults with and without Respiratory or Gastrointestinal Infections

Mohanraj

Jokinen

Thapa

et al. 2021

Viruses

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“…Phan et al have found cutavirus DNA in 23.5% (4/17) ( 1 ) and Väisänen et al in 16% (4/25) of CTCL of the mycosis fungoides type ( 5 ). Our group recently analyzed 189 biopsies of various cutaneous B- and T-cell lymphoma types and detected cutavirus DNA only in 5.8% of 104 mycosis fungoides biopsy specimens ( 7 ). In contrast, Bergallo et al could not detect cutavirus in 55 CTCL samples ( 8 ).…”

mentioning

confidence: 99%

No Evidence for Role of Cutavirus in Malignant Melanoma

Wieland¹,

Silling²,

Hufbauer³

et al. 2019

Emerg. Infect. Dis.

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“…In 2016, CuV was found in human fecal samples and cutaneous T-cell lymphomas (CTCL) [5,11]. While CuV DNA was found in skin biopsies from~5% of German and 16% of Finnish patients with CTCL [16,17], it was absent in healthy patients, providing a statistically significant association to CTCL [17]. It has been infrequently detected also in malignant skin melanomas and carcinomas [11,17,18].…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization of Cuta- and Tusavirus: Insight into Protoparvoviruses Capsid Morphology

Mietzsch

McKenna

Väisänen

et al. 2020

Viruses

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Several members of the Protoparvovirus genus, capable of infecting humans, have been recently discovered, including cutavirus (CuV) and tusavirus (TuV). To begin the characterization of these viruses, we have used cryo-electron microscopy and image reconstruction to determine their capsid structures to ~2.9 Å resolution, and glycan array and cell-based assays to identify glycans utilized for cellular entry. Structural comparisons show that the CuV and TuV capsids share common features with other parvoviruses, including an eight-stranded anti-parallel β-barrel, depressions at the icosahedral 2-fold and surrounding the 5-fold axes, and a channel at the 5-fold axes. However, the viruses exhibit significant topological differences in their viral protein surface loops. These result in three separated 3-fold protrusions, similar to the bufaviruses also infecting humans, suggesting a host-driven structure evolution. The surface loops contain residues involved in receptor binding, cellular trafficking, and antigenic reactivity in other parvoviruses. In addition, terminal sialic acid was identified as the glycan potentially utilized by both CuV and TuV for cellular entry, with TuV showing additional recognition of poly-sialic acid and sialylated Lewis X (sLeXLeXLeX) motifs reported to be upregulated in neurotropic and cancer cells, respectively. These structures provide a platform for annotating the cellular interactions of these human pathogens.

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Cutavirus Infection in Primary Cutaneous B- and T-Cell Lymphoma

Abstract: Drs Halpern and Gonzalez reported having served on the scientific advisory board of Caliber Imaging and Diagnostics. No other disclosures were reported.

Cited by 15 publications

References 5 publications

Human Protoparvovirus DNA and IgG in Children and Adults with and without Respiratory or Gastrointestinal Infections

Human Protoparvovirus DNA and IgG in Children and Adults with and without Respiratory or Gastrointestinal Infections

No Evidence for Role of Cutavirus in Malignant Melanoma

Structural Characterization of Cuta- and Tusavirus: Insight into Protoparvoviruses Capsid Morphology

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