Cutaneous zygomycosis

Bonifáz, Alexandro; Vázquez-González, Denisse; Tirado‐Sánchez, Andrés; Ponce-Olivera, Rosa María

doi:10.1016/j.clindermatol.2011.09.013

Cited by 46 publications

(54 citation statements)

References 39 publications

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“…The present case, from a clinical perspective, is similar to others reported (3,8,9). We believe that the infection was acquired through a skin laceration and inoculation of a foreign body of small diameter during the accident and encouraged by the location of the Philadelphia collar, which probably created an optimal microenvironment for the fungus.…”

Section: Figsupporting

confidence: 68%

“…We need to draw attention to the rapid progress of the infection, which spread and deepened easily in a manner typically characteristic of necrotizing fasciitis (4,10,11). Although the patient would have been considered immunocompetent, the history of controlled type 2 diabetes mellitus, which is a high-risk factor for infection by Mucorales (3,12), should be emphasized. Roden et al (13) stated that there is a 19% incidence of PCM, with 34% of cases due to traumatic inoculation and only 3% associated with car crashes.…”

Section: Figmentioning

confidence: 99%

“…In our experience, approximately 70% of cases have presented a cutaneous expansion related to uncontrolled diabetes mellitus and immunosuppression (neutropenia) (3). PCM is usually acquired by inoculation of material contaminated with spores, as in cases of sites of venipuncture and application of adhesive tapes in severely immunocompromised hosts (3,4). However, PCM can also occur in immunocompetent individuals, where the only predisposing factors identified are serious injuries (burns, car crashes) (3,4).…”

Section: Figmentioning

confidence: 99%

“…PCM is usually acquired by inoculation of material contaminated with spores, as in cases of sites of venipuncture and application of adhesive tapes in severely immunocompromised hosts (3,4). However, PCM can also occur in immunocompetent individuals, where the only predisposing factors identified are serious injuries (burns, car crashes) (3,4). There have been recent reports and small outbreaks caused by lacerations and injuries due to tornadoes (5, 6) and other natural disasters, such as tsunamis and volcanic eruptions (4, 7).…”

Section: Figmentioning

confidence: 99%

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Primary Cutaneous Mucormycosis Produced by the New Species Apophysomyces mexicanus

et al. 2014

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A case of fungal necrotizing fasciitis that appeared in an immunocompetent Mexican woman after a car accident is described. The patient did not respond to antifungal treatment and died 4 days later. The fungus was molecularly identified as a new species of Apophysomyces, namely, Apophysomyces mexicanus. CASE REPORTA 46-year-old woman was admitted to an emergency department 6 days after she suffered a rollover car accident, which occurred on a highway in a semiarid region with 75% relative humidity; the patient was ejected 10 meters from the car during the rollover, with consequent T12 vertebral fracture, Frankel grade B spinal cord injury, and superficial abrasions and lacerations over the neck. The patient was immobilized with a Philadelphia collar immediately after the accident, and her medical history showed type 2 diabetes mellitus, controlled with metformin-glibenclamide, and an allergy to nonsteroidal anti-inflammatory drugs. She received initial treatment in a regional hospital and was transferred to the emergency department of the Lic. Adolfo López Mateos Hospital 6 days later. After the collar was removed, a 3-cm-diameter fixed, irregular, red, swollen area was observed with a central necrosis of about 1 cm in length over the right posterior cervical triangle (Fig. 1A), along with multiple abrasions of the neck. Initial laboratory test results showed leukocytosis of 17 ϫ 10 9 /liter, glucose at 10.77 mmol/liter, hemoglobin at 121 g/liter, hematocrit at 0.352 liter/liter, urea nitrogen at 3.92 mmol/ liter, urea at 3.92 mmol/liter, and creatinine at 53.04 mmol/liter. A computed tomography (CT) scan of the neck after administration of contrast material revealed isodense homogeneous soft tissue bulking posterior to the sternocleidomastoid muscle, with no evidence of foreign bodies. An escharectomy was carried out, and ceftriaxone (2 g/day) and clindamycin (1.2 g/day) were administered. On the second day, the cellulitis and necrosis areas expanded to 10 cm in length (Fig. 1B), affecting the posterior, muscular, and submandibular cervical triangles. The patient underwent surgical exploration of the neck and debridement, which showed necrotic tissue that extended as far as the muscle. Material was collected and sent to the laboratory for histopathological examination and microbial culture. Direct mountings on KOH (10% [wt/vol]) showed dichotomously branched, broad coenocytic hyphae (Fig. 1C), similar to those observed on hematoxylin-eosin histopathology preparations (Fig. 1D). Culturing on Sabouraud dextrose agar (Difco/Becton Dickinson, Mexico) produced white, cottony fungal colonies made of pauciseptated hyphae evocative of a fungus belonging to Mucorales. Consequently, primary cutaneous mucormycosis (PCM) was diagnosed; therefore, amphotericin B deoxycholate (0.5 mg/kg of body weight/ day) and fluconazole (400 mg/day) were administered. A second debridement removed all necrotic tissue, reaching the free edges of the lesion and leaving a surgical mark (10 by 15 cm) (Fig. 1E). Despite antifungal treatment, th...

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Section: Figsupporting

confidence: 68%

Section: Figmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

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Primary Cutaneous Mucormycosis Produced by the New Species Apophysomyces mexicanus

et al. 2014

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“…The rhino-cerebral form of mycormycosis is most common followed by pulmonary, cutaneous and subcutaneous, gastrointestinal and disseminated form [3,4]. It is transmitted by inhalation, percutaneously or by ingestion of spores.…”

Section: Resultsmentioning

confidence: 99%

5 Year-old Boy with a Hearth Murmur and Fever

Dikkers

Ach²,

Lequin

2016

J Pulm Respir Med

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Fungal Infections

Hay

2024

Rook's Textbook of Dermatology

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Fungal infections are diseases affecting the skin and subcutaneous tissue. They include common conditions such as dermatophytosis or ringworm, Malassezia infection and superficial Candida infection. Subcutaneous fungal infections are now amongst the conditions classified as neglected tropical diseases (NTDs) or skin NTDs. Life‐threatening systemic mycoses which are internal infections can also affect the skin, often after blood stream dissemination. They are diagnosed by a combination of microscopy, histopathology and fungal culture, which is increasingly being replaced by molecular detection methods. There is also a wide range of antifungal agents available including griseofulvin, topical azole antifungals, itraconazole, fluconazole and the allylamine, terbinafine. Deeper infections are often treated with voriconazole, amphotericin B or echinocandin drugs, although there are increasing reports of antifungal drug resistance.

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Cutaneous zygomycosis

Cited by 46 publications

References 39 publications

Primary Cutaneous Mucormycosis Produced by the New Species Apophysomyces mexicanus

Primary Cutaneous Mucormycosis Produced by the New Species Apophysomyces mexicanus

5 Year-old Boy with a Hearth Murmur and Fever

Fungal Infections

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