Cutaneous Xanthomas Associated With Chronic Myelomonocytic Leukemia

Diffuse plane normolipemic xanthoma associated with chronic myelomonocytic leukemia-1

“…Kim et al [6] reported a case of DNPX associated with chronic myeloid leukemia. The present case, together with the case reported by Kim et al [6], support the hypothesis proposed by Vail et al [5] described above. The present case, together with the case reported by Kim et al [6], support the hypothesis proposed by Vail et al [5] described above.…”

“…On physical examination, well-demarcated, yellow-orange to yellow-brown, flat to slightly elevated plaques were present on the eyelids and cheeks ( figure 1A). Xanthelasma is present in most cases of DNPX [1,5,6], including the present case, and precedes the appearance of other lesions [1,6]. A yellow patch with a poorly defined border was present on the left upper arm ( figure 1C).…”

“…Three of those 45 cases, including our patient, were associated with either chronic myelomonocytic [5,8] or chronic myeloid [6] leukemia. Three of those 45 cases, including our patient, were associated with either chronic myelomonocytic [5,8] or chronic myeloid [6] leukemia.…”

“…In addi- tion, slightly elevated, yellow-orange plaques were present on the skin overlying the clavicles and sternal manubrium ( figure 1B). However, Vail et al reported that xanthelasma developed after the occurrence of other DNPX lesions [5]. Skin biopsies were taken from a plaque on the right cheek and the patch on the left upper arm.…”

“…A non-uremic form is also well described, defined as the absence of ESRF, renal transplantation, acute kidney injury requiring renal replacement therapy (RRT) and severe chronic kidney disease (CKD) [2]. Associations with the risk of calciphylaxis include high serum phosphate, calcium/phosphate product and aluminium, secondary hyperparathyroidism, warfarin and steroid use, obesity, liver disease, female sex, and hypoalbuminemia [3][4][5]. Mortality rates are 60-80% and death results mainly from sepsis [5].…”