Cutaneous Wounds Produced by Capsaicin Treatment of Newborn Rats Are Due to Trophic Disturbances

Carrillo, Porfirio; Camacho, Miguel Ángel Martínez; Manzo, Jorge; Martı́nez–Gómez, Margarita; Salas, Manuel; Pacheco, Pablo

doi:10.1016/s0892-0362(97)00077-9

Cited by 12 publications

(14 citation statements)

References 35 publications

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“…Since the size of the spontaneous lesions was sometimes greater than that of the surgical wounds in control animals, the results should be regarded with caution. Nevertheless, the findings are in accordance with data on capsaicinevoked lesions in newborn rats, which heal within 20-30 days in the case of those which are largest [6]. In our previous study of surgical wounds of the skin in the thigh area, the 70% depletion of all neuropeptide-containing C fibers (by systemic treatment with capsaicin) did not impair the wound healing process [9].…”

Section: Discussionsupporting

confidence: 90%

“…The appearance of the skin lesions in the head and neck area of rats treated with capsaicin neonatally has been ascribed to intensified self-grooming and scratching behavior [7]. It has been shown that rats treated neonatally with capsaicin scratch themselves more frequently than control rats [6]. Indeed, a positive correlation was found between the frequency of scratching and the area of skin damage [5].…”

Section: Discussionmentioning

confidence: 99%

“…Several investigators working with rats and guinea pigs receiving capsaicin neonatally have described the appearance of cutaneous lesions in the head region [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Local Skin Lesions in the Rat after Subcutaneous Deposition of Capsaicin

Wallengren¹,

Chen

2002

Skin Pharmacol Physiol

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Capsaicin is used to investigate the role of peripheral sensory nerve fibers. In previous studies of rats treated by injection of capsaicin into the skin of the neck, ‘spontaneous’ lesions in the head and neck region were observed. In this study, the course of development over time, the regional distribution and the innervation of capsaicin-induced dermal lesions were assessed in young male Sprague-Dawley rats. In one experiment, capsaicin was administered subcutaneously by injection in the skin of the neck. In a second experiment, capsaicin was injected in the back by a long needle that tunneled under the skin and allowed the capsaicin to be deposited in the subcutaneous fat of the neck. The density and the distribution of dermal nerve fibers were investigated by immunohistochemistry, using antisera against a panneuronal marker, protein gene product 9.5 (PGP), and calcitonin gene-related peptide (CGRP). In the first experiment, rats developed lesions in the neck area 11 days after injection. In the second experiment, lesions appeared in the skin of the back and occasionally in the neck area 10 days after injection. Development of lesions in the afflicted areas was paralleled by local reduction in the density of CGRP-immunoreactive (IR) nerve fibers, 80% in the first experiment and 72% in the second. The number of PGP-IR fibers was likewise reduced, by 39 and 41%, respectively. The density of the CGRP-IR fibers in the wound area was the same as in the adjacent, nonlesioned skin. The healing of the capsaicin-induced lesions was slow compared with surgical wounds in control animals. The wounds healed with hypertrophic scars. The healing process in the skin of the back was associated with the proliferation of CGRP-IR fibers. The study shows cutaneous lesions to appear in the region of the subcutaneous deposition of capsaicin. A uniform depletion of capsaicin-sensitive nerve fibers in the area of deposition suggests that an additional factor is needed to induce lesions. Possibly, impaired nociception in the afflicted area results in more vigorous grooming behavior and this, in turn, in a local skin damage.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Local Skin Lesions in the Rat after Subcutaneous Deposition of Capsaicin

Wallengren¹,

Chen

2002

Skin Pharmacol Physiol

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“…A careful search of the literature revealed that this effect already has been recognized by some investigators [2][3][4]. It has been speculated that dysfunction in the nervous system, due to the ablation of capsaicin-sensitive nerve fibers, might be related to the induction of pruritus and scratches, leading to the transient cutaneous lesions [3,4]. However, it is interesting that even in rats wearing a plastic collar to protect themselves from scratching-induced damage, cutaneous lesions were still readily detectable [4], indicating that the scratch itself may not be critical in the manifestation of cutaneous lesion in these rat.…”

Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 97%

Chronically relapsing pruritic dermatitis in the rats treated as neonate with capsaicin; a potential rat model of human atopic dermatitis

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Jeong

et al. 2012

Journal of Dermatological Science

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Delta opioid receptor activation modulates affective pain and modality‐specific pain hypersensitivity associated with chronic neuropathic pain

Cahill

Holdridge

Liu

et al. 2020

J of Neuroscience Research

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Delta opioid receptor (DOR) agonists alleviate nociceptive behaviors in various chronic pain models, including neuropathic pain, while having minimal effect on sensory thresholds in the absence of injury. The mechanisms underlying nerve injury-induced enhancement of DOR function are unclear. We used a peripheral nerve injury (PNI) model of neuropathic pain to assess changes in the function and localization of DORs in mice and rats. Intrathecal administration of DOR agonists reversed mechanical allodynia and thermal hyperalgesia. The dose-dependent thermal antinociceptive effects of DOR agonists were shifted to the left in PNI rats. Administration of DOR

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Cutaneous Wounds Produced by Capsaicin Treatment of Newborn Rats Are Due to Trophic Disturbances

Cited by 12 publications

References 35 publications

Local Skin Lesions in the Rat after Subcutaneous Deposition of Capsaicin

Local Skin Lesions in the Rat after Subcutaneous Deposition of Capsaicin

Chronically relapsing pruritic dermatitis in the rats treated as neonate with capsaicin; a potential rat model of human atopic dermatitis

Delta opioid receptor activation modulates affective pain and modality‐specific pain hypersensitivity associated with chronic neuropathic pain

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