Cutaneous wound healing using polymeric surgical dressings based on chitosan, sodium hyaluronate and resveratrol. A preclinical experimental study

Berce, Cristian; Muresan, Mihai-Stefan; Şoriţău, Olga; Petrushev, Bobe; Tefas, Lucia Ruxandra; Rigo, Isabella; Ungureanu, Gheorghe; Cătoi, Cornel; Irimie, Alexandra Iulia; Tomuleasa, Ciprian

doi:10.1016/j.colsurfb.2017.12.041

Cited by 43 publications

(28 citation statements)

References 57 publications

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“…A number of observations suggested that, in murine models of full-thickness wound, resveratrol stimulates cell proliferation and collagen, leading to acceleration in cutaneous wound healing. Application of wound dressings containing resveratrol to full-thickness skin wounds induced marked reductions in wound areas in comparison with the controls [122]. Similar acceleration in wound closure occurs following the placement of scaffolds containing resveratrol over the wound [123].…”

Section: Anti-inflammationmentioning

confidence: 75%

“…Rats were fed with resveratrol at a daily dose of 0.5 mg/kg body weight 7 days prior to operation and continued throughout the whole experiment period ↑Collagen deposition ↑Neovascularization ↑Fibroblast maturation ND [120] Following induction of full-thickness skin wound, wound was treated topically with 225 μL of 50 μM once daily for 17 days ↑Epithelialization ↓Wound size ↑Collagen deposition ↑Vascularization ↑AMPK pathway and SIRT1 [121] Mice Immediately after wound, a wound dressing containing 0.04% resveratrol was applied to full-thickness skin wound for 10 days ↓Wound size ↑Collagen fibers ↓Inflammation ND [122] Placing scaffolds containing 5% resveratrol on the wound for 7 days ↓Wound size ↑Expression of thioredoxin-1, heme oxygenase-1, and VEGF [123] Evidence-Based Complementary and Alternative Medicine structures for epidermal permeability barrier, requires transglutaminase [127]. Treatment of keratinocytes with resveratrol induced a dose-dependent increase in transglutaminase activity, while simultaneously inhibiting DNA synthesis, with a half-maximal concentration of 35 μM.…”

Section: Ratsmentioning

confidence: 99%

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Role of Resveratrol in Regulating Cutaneous Functions

Wen

Zhang

Yang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Protective role of the skin is against external insults and maintenance of electrolyte homeostasis of the body. Cutaneous dysfunction can account for the development of both cutaneous and systemic disorders. Thus, improvements in cutaneous functions can benefit a number of extracutaneous and cutaneous functions. Resveratrol, a natural ingredient, displays multiple benefits for various systems/organs, including the skin. The benefits of resveratrol for cutaneous functions include stimulation of keratinocyte differentiation and antimicrobial peptide expression, inhibition of keratinocyte proliferation and cutaneous inflammation, UV protection, anticancer, antiaging, and inhibition of melanogenesis. The mechanisms of action of resveratrol include activation of sirtuin 1 and nuclear factor erythroid 2-related factor 2, and inhibition of mitogen-activated protein kinase signaling. Evidence suggests that topical resveratrol could be a valuable alternative not only for daily skin care, but also for the prevention and treatment of various cutaneous disorders. This review summarizes the benefits of resveratrol for cutaneous functions.

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Section: Anti-inflammationmentioning

confidence: 75%

Section: Ratsmentioning

confidence: 99%

Role of Resveratrol in Regulating Cutaneous Functions

Wen

Zhang

Yang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Likewise, resveratrol, another natural polyphenol, has also been investigated for its anti‐inflammatory and bacteriostatic properties. Berce et al fabricated chitosan‐sodium hyaluronate‐resveratrol sponges that were shown to support the formation of granulation tissue with reduced neutrophilic infiltration in mice . Furthermore, the construct displayed a lack of bacterial contamination compared to the control, and supported local angiogenesis and re‐epithelialization.…”

Section: Advanced Tissue Engineering Approaches To Regenerate Skinmentioning

confidence: 99%

Current and Future Perspectives on Skin Tissue Engineering: Key Features of Biomedical Research, Translational Assessment, and Clinical Application

Navarro

Coburn

et al. 2019

Adv Healthcare Materials

157

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The skin is responsible for several important physiological functions and has enormous clinical significance in wound healing. Tissue engineered substitutes may be used in patients suffering from skin injuries to support regeneration of the epidermis, dermis, or both. Skin substitutes are also gaining traction in the cosmetics and pharmaceutical industries as alternatives to animal models for product testing. Recent biomedical advances, ranging from cellular‐level therapies such as mesenchymal stem cell or growth factor delivery, to large‐scale biofabrication techniques including 3D printing, have enabled the implementation of unique strategies and novel biomaterials to recapitulate the biological, architectural, and functional complexity of native skin. This progress report highlights some of the latest approaches to skin regeneration and biofabrication using tissue engineering techniques. Current challenges in fabricating multilayered skin are addressed, and perspectives on efforts and strategies to meet those limitations are provided. Commercially available skin substitute technologies are also examined, and strategies to recapitulate native physiology, the role of regulatory agencies in supporting translation, as well as current clinical needs, are reviewed. By considering each of these perspectives while moving from bench to bedside, tissue engineering may be leveraged to create improved skin substitutes for both in vitro testing and clinical applications.

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“…Przykłady mikro i nanonośników resweratrolu. Polimerowe membrany kolagen, laminina, chitozan in vitro oraz in vivo na szczurach [26,27] 24 h inkubacji, w teście MTS największą przeżywalność komórek gwarantowało zastosowanie liposomów z resweratrolem. Wykazano, że dzięki takiemu rozwiązaniu zwiększa się skuteczność resweratrolu w zapobieganiu i leczeniu uszkodzeń skóry związanej z nadmierną ekspozycją na promieniowanie UV.…”

Section: Charakterystyka Resweratroluunclassified