Cutaneous wound closure materials: An overview and update

Al-Mubarak, Luluah; Al-Haddab, Mohammed

doi:10.4103/0974-2077.123395

Cited by 131 publications

(89 citation statements)

References 56 publications

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“…Sutures are classified as absorbable or non-absorbable, natural or synthetic, and multi-filament or monofilament ones [5]. Each of them has its own merits and demerits.…”

Section: Introductionmentioning

confidence: 99%

“…Non-absorbable sutures are characterized by the resistance to biodegradability. They include natural (surgical steel, silk, cotton, and linen) and synthetic non-absorbable sutures (nylon, polypropylene, and polybutester) [5][6][7]. Advantages of non-absorbable sutures include strength, a lack of premature breakage, and a minimal risk of inflammatory responses [7].…”

Section: Introductionmentioning

confidence: 99%

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Biomechanical Properties and Biocompatibility of a Non-Absorbable Elastic Thread

Choi¹,

Kang²,

Choi³

et al. 2019

JFB

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To date, extensive studies have been conducted to assess diverse types of sutures. But there is a paucity of data regarding biomechanical properties of commonly used suture materials. In the current experiment, we compared biomechanical properties and biocompatibility, such as tensile strength and elongation, the degree of bovine serum albumin (BSA) release, in vitro cytotoxicity and ex vivo frictional properties, between a non-absorbable elastic thread (NAT; HansBiomed Co. Ltd., Seoul, Korea) (NAT-R: NAT with a rough surface, NAT-S: NAT with a smooth surface) and the Elasticum® (Korpo SRL, Genova, Italy). The degree of tensile strength and elongation of Si threads was significantly higher in both the NAT-R and -S as compared with the Elasticum® (p < 0.05). Moreover, the degree of tensile strength and elongation of PET threads was significantly lower in both NAT-R and -S as compared with the Elasticum® (p < 0.05). Furthermore, the degree of tensile strength and elongation of braided Si/PET threads was significantly lower in NAT-S as compared with NAT-R and Elasticum® (p < 0.05). The degree of BSA release was significantly higher in the NAT-R as compared with Elasticum® and NAT-S throughout a 2-h period in the descending order (p < 0.05). The degree of cell viability was significantly higher in both NAT-R and -S as compared with Elasticum® (p < 0.05). The degree of coefficient of friction as well as the frictional force and strength was significantly higher in NAT-R as compared with NAT-S and Elasticum® (p < 0.05). NAT had a higher degree of biomechanical properties and biocompatibility as compared with Elasticum®. But further experimental and clinical studies are warranted to compare the efficacy, safety, and potential role as a carrier for drug delivery between NAT and Elasticum®.

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“…Sutures are classified as absorbable or non-absorbable, natural or synthetic, and multi-filament or monofilament ones [5]. Each of them has its own merits and demerits.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biomechanical Properties and Biocompatibility of a Non-Absorbable Elastic Thread

Choi¹,

Kang²,

Choi³

et al. 2019

JFB

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“…In a suture, fibers are pulled through the intact tissue to displace the edges of the wound together. There are two classes of sutures, interrupted and continuous, each with several types of stiches [90][91][92][93][94]. The number of strands and material of the suture affects the effectiveness of the suture [95].…”

Section: Soft Composite Damage and Repairmentioning

confidence: 99%

Biofidelic soft composites–experimental and computational modeling

Chanda¹

2018

Preprint

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Biofidelic soft composites or tissues form the building blocks of the human body. Understanding the complex mechanics of these soft composites is the key to understanding the genesis and progression of disease. Biomechanically, soft composites exhibit anisotropic mechanical behavior and comprise of multiple fiber layers within a soft matrix. To date, there is a lack of understanding of the anisotropic mechanical behavior of soft composites, primarily due to unavailability of a robust characterization framework. In this dissertation, novel multiscale computational and experimental investigation models are developed to simulate and characterize anisotropic soft composite mechanical behavior. Soft composite surrogates were first developed to simulate various tissues in the human body namely the skin, brain, artery and vaginal tissues. Novel anisotropic soft composite models were also fabricated taking into consideration the tissue anisotropy and multifunctional properties. Hyperelastic anisotropic constitutive relationships were formulated to precisely characterize the mechanical behavior of soft composite considering varying fiber and matrix contributions, fiber-matrix interactions, fiber orientations and multiple fiber layers. Coupled with high fidelity experimental and computational models, microscopy, and Digital Image Correlation (DIC) studies, the damage and repair of soft composite surrogates are also discussed in this dissertation, with relevance to soft tissue wounds and suture. Computational modeling to understand the interaction between multiple soft composite systems and its effect on soft composite damage are also highlighted in this work. Some specific soft composite interaction systems modeled were the female pelvic system under abdominal loads, whole body impact due to blast, and ulceration in diabetic foot. This dissertation lays the foundation for micro and macro scale anisotropic soft composite modeling and characterization using high fidelity experimental and numerical techniques which will be indispensable for studying tissue mechanics and other soft composite applications in engineering and medicine.

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“…Present‐day tissue adhesives (TAs) can be divided into four categories based on their chemical composition . Cyanoacrylates (CA), the largest TA category, are known to form a rigid and watertight bond and have been recently proposed to be potential candidates for the sealing of bowel anastomoses . Fibrin glues (FGs) act as hemostats by enhancing the final stage of the clotting cascade and form a network of fibrin molecules with the adhesive substrate, and have been useful in the sealing of experimental colorectal anastomoses .…”

Section: Introductionmentioning

confidence: 99%

“…8 Cyanoacrylates (CA), the largest TA category, are known to form a rigid and watertight bond and have been recently proposed to be potential candidates for the sealing of bowel anastomoses. 5,9 Fibrin glues (FGs) act as hemostats by enhancing the final stage of the clotting cascade and form a network of fibrin molecules with the adhesive substrate, and have been useful in the sealing of experimental colorectal anastomoses. [10][11][12][13] Polyethylene glycol adhesives (PEGs) are flexible hydrogels, primarily used in neurosurgery for sealing the Dura mater.…”

Section: Introductionmentioning

confidence: 99%

Clinical, mechanical, and immunohistopathological effects of tissue adhesives on the colon: An in‐vivo study

Vakalopoulos

Kroese

et al. 2016

J Biomed Mater Res

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Background: Tissue adhesives may be useful for sealing bowel anastomoses by preventing anastomotic leakage. Prior to clinical implementation, an in-depth analysis of the clinical and immunohistopathological effects of tissue adhesives on the target tissue and of the mechanical strength of the adhesive bond in an in vivo model is needed. Materials and methods:In 84 rats, two bowel segments were glued using one of the following tissue adhesive: Bioglue, Gelatin-resorcinol-formaldehyde (GRF), Glubran 2, Histoacryl Flex, Omnex, Duraseal Xact, or Tissucol. Rats were followed for 7 or 28 days. Endpoints were clinical complication rate, mechanical strength, and immunohistopathological reactions. Results: Of the seven tissue adhesives, GRF and Bioglue showed the highest rates of bowel wall destruction and ileus and the most severe immunohistopathological tissue reactions at 7 and 28 days. Cyanoacrylates (Histoacryl Flex, Omnex, Glubran 2) showed high mechanical strength and mild immunohistopathological reactions at 7 and 28 days. Duraseal Xact and Tissucol were the most inert tissue adhesives, but exhibited low mechanical strength. At 28 days, mechanical strength was significantly correlated to CD8, CD68, and Ki67 cell counts. Conclusion: Based on the clinical and immunohistopathological outcomes, GRF and Bioglue were found to be the least suitable tissue adhesives for colonic use. Duraseal Xact and Tissucol were inert but also showed low mechanical strength. Cyanoacrylates exhibited mild clinical and immunohistopathological effects while maintaining high strength, which makes them promising as colonic sealants.

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Cutaneous wound closure materials: An overview and update

Cited by 131 publications

References 56 publications

Biomechanical Properties and Biocompatibility of a Non-Absorbable Elastic Thread

Biomechanical Properties and Biocompatibility of a Non-Absorbable Elastic Thread

Biofidelic soft composites–experimental and computational modeling

Clinical, mechanical, and immunohistopathological effects of tissue adhesives on the colon: An in‐vivo study

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