Cutaneous Vasculitis Associated With Propylthiouracil Therapy

Carrasco, Mark

doi:10.1001/archinte.1987.00370090153027

Cited by 16 publications

(2 citation statements)

References 5 publications

(1 reference statement)

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“…The cold season in which the eruption occurred may also support such hypothesis. However, the ears are typically involved also in propylthiouracil‐induced vasculitis, which, incidentally, produces similar immunological abnormalities, 15 and in acute haemorrhagic oedema of the newborn, which in fact represents an idiopathic leucocytoclastic vasculitis 16 and bears some clinical resemblance to our cases.…”

Section: Discussionsupporting

confidence: 56%

Purpura of the ears: a distinctive vasculopathy with circulating autoantibodies complicating long-term treatment with levamisole in children

Rongioletti

Ghio

Ginevri³

et al. 1999

British Journal of Dermatology

136

118

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The cutaneous side-effects of levamisole include non-specific and lichenoid eruptions, fixed drug eruption and, very rarely, cutaneous vasculitis. We describe a distinctive clinical and histological vasculopathy with immunological abnormalities in children with paediatric nephrotic syndrome receiving long-term levamisole treatment. Four boys and one girl were identified. Their average age was 10 years. Levamisole had been used for an average of 24 months. Purpura of the ears was the most common finding corresponding histologically to a vasculopathic reaction pattern ranging from a leucocytoclastic and thrombotic vasculitis to a vascular occlusive disease without true vasculitis but with associated antinuclear, antiphospholipid and anticytoplasmic antibodies. The eruption resolved in all patients 2-3 weeks after the discontinuation of levamisole, but serum autoantibodies persisted for 2-14 months.

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Section: Discussionsupporting

confidence: 56%

Purpura of the ears: a distinctive vasculopathy with circulating autoantibodies complicating long-term treatment with levamisole in children

Rongioletti

Ghio

Ginevri³

et al. 1999

British Journal of Dermatology

136

118

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“…13,14 Causes of drug-induced AAV include intake of propylthiouracil, minocycline, allopurinol, and levamisole. Drug-induced AAV manifests as retiform purpura, painful subcutaneous nodules, and palpable purpura 13,14 (with a predilection for the face and earlobes in propylthiouracil-and levamisole-induced cases), 15,16 commonly with neutropenia. Direct immunofluorescence of cutaneous lesions reveals immune complex deposition in blood vessel walls.…”

Section: Discussionmentioning

confidence: 99%