Cutaneous tuberculosis- a clinico-pathological study

Agrawal, Ranjan; Kumar, Mukta; Kumar, P.

doi:10.7713/ijms.2012.0044

Cited by 3 publications

(2 citation statements)

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“…and Kumar et al29 our study we could demonstrate Acid Fast Bacilli (AFB) in 19% of patients by Ziehl Neelsen staining (ZN stain) method in pathological sections, this is similar to studies by M. Naveduz Zafar et al22 who found AFB in 18.42% cases and Ranjan Agarwal et al31 who found AFB in 17.19% cases but is not in accordance with the results of Mahaisavariya et al30 who found AFB in 30.77% cases.…”

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confidence: 76%

Histopathological Evaluation of Chronic Non Healing Ulcers of Skin in Patients Referred to Tertiary Care Hospital in Kashmir.

khaliq¹

2018

IJAR

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Background: Skin is the single largest organ of the body that protects against mechanical trauma, radiation and infection. Because of its complexity a wide range of diseases can develop from the skin ranging from infectious diseases to malignancy, some of which may present as non-healing ulcers. Non healing ulcers are an important cause of morbidity in developing countries. Study of non-healing skin ulcers is challenging and at times even frustrating than any other skin lesions. This study was taken keeping in view the present scenario were patient with non-healing ulcers go unnoticed for a long time without biopsy resulting in uncertainty of developing malignancy which can otherwise be identified at a very early stage by early histopathological examination. Aim: Aim of this study was to study the histopathological outcome of non-healing ulcers in this geographical area where much is not known about the etiology of non-healing ulcers. Methodology: This study was hospital based two years prospective study extending from January 2016 to December 2017 conducted in Department of Pathology, Government Medical College Srinagar. During this period patients referred from peripheral hospitals with ulcers that had not healed for 4 weeks or more after conventional therapies were included in this study. The detailed history and clinical examination findings were retrieved from the case files. Biopsies received were processed as per the standard protocol and slides were examined by the senior pathologist in the Department of Pathology, Government Medical College Srinagar. Results: During the two years period department received biopsies from 282 patients with non-healing ulcers. Out of 282 patients 180 were males and 102 were females with a M:F ratio of 1.76:1. 0ut of the 282 cases 100 (35.46%) were diagnosed as malignant ulcers and 182(64.54%) were diagnosed as benign ulcers (Table 1). Out of the 282 cases, 70 cases (24.82%) were found to be neuropathic diabetic ulcers, 52 (18.43%) were diagnosed as tubercular ulcers, 44 (15.60%) as infectious, 4 (1.42%) as leprosy, 4 (1.42%) cases were due to parasitic infection (cutaneous leishmaniasis) and 8 cases (2.83%) as others. Benign ulcers were found to be fairly common below 50 years

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confidence: 76%

Histopathological Evaluation of Chronic Non Healing Ulcers of Skin in Patients Referred to Tertiary Care Hospital in Kashmir.

khaliq¹

2018

IJAR

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“…Ulserasi, atrofi atau akantosis dapat ditemukan pada epidermis diatasnya. 13,14 Gambaran histopatologi skrofuloderma pada dermis berupa pembentukan abses disertai ulserasi. Tuberkel dan nekrosis kaseosa dapat ditemukan di perifer dengan bakteri dalam jumlah banyak.…”

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Lupus Vulgaris Dengan Lesi Diseminata

Jayadi¹,

Ernaningtyas²,

Niode³

et al. 2015

JBM

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Lupus vulgaris (LV) is a chronic progressive form of paucibacillary cutaneous tuberculosis. Lesion is usually solitary in the form of nodes or erythematous plaques with an apple-jelly sign on diascopy. Disseminated LV is a rare form of cutanoeus tuberculosis with multiple lesions in several body areas. We reported a male of 40 years old with a suppurative wound on the left neck and reddish nodules on the face, neck, trunk, and limbs along with fever, night sweats, weight loss, and history of previous TB infections. There were multiple erythematous nodules and painful suppurating ulcers with enlargement of several lymph nodes. Apple-jelly sign appeared on diascopy. The FNAB showed specific granulamatous inflammation for TB with lymphocytes, epitheloid macrophages, and multinucleated giant cells. The histopathological finding showed tubercles surrounded by macrophages and lymphocytes. Anti-tuberculosis drugs category I were given for 6 months, ofloxacin, and open wound care compressed with NaCl 0.9%. In the third month of observation, there was significant improvement. Conclusion: This case was diagnosed as lupus vulgaris based on the history of lymphadenitis TB and scrofuloderma, lesions in several body area with positive diascopy test, the FNAB as well as the histopathologic result supporting the diagnosis of tuberculosis, and there was significant improvement after treatment with antiTB drugs.Keywords: lupus vulgaris, diseminata, tuberculosis, ofloksasinAbstrak: Lupus vulgaris (LV) merupakan tuberkulosis (TB) kutis pausibasiler kronis dan progresif. Lesi biasanya soliter, berupa nodus atau plak eritematosa dengan gambaran apple-jelly pada diaskopi. Lupus vulgaris diseminata merupakan bentuk TB kutis yang jarang ditemukan dengan lesi multipel pada beberapa area tubuh secara bersamaan. Kami melaporkan seorang laki-laki, 40 tahun, dengan luka bernanah pada leher kiri dan benjolan-benjolan kemerahan pada wajah, leher, badan, dan tungkai disertai demam, keringat malam, penurunan berat badan dan riwayat infeksi tuberkulosis sebelumnya. Pada pemeriksaan fisik tampak nodus eritematosa multipel disertai ulkus bernanah dan pembesaran beberapa kelenjar getah bening. Gambaran apple-jelly tampak pada diaskopi. Pemeriksaan FNAB menunjukkan gambaran radang granulomatik spesifik TB dengan adanya sel-sel radang limfosit, kelompok makrofag epiteloid, dan sel-sel datia Langhans. Pemeriksaan histopatologis memberikan gambaran tuberkel yang dikelilingi oleh makrofag dan limfosit. Terapi diberikan berupa OAT kategori I selama 6 bulan, ofloksasin, dan kompres terbuka dengan NaCL 0,9%. Pada bulan ketiga tampak perbaikan signifikan. Simpulan: Pada kasus ini, diagnosis lupus vulgaris ditegakkan berdasarkan adanya riwayat limfadenitis TB dan skrofuloderma, lesi di beberapa area tubuh sekaligus dengan pemeriksaan diaskopi positif, gambaran FNAB dan histopatologis menunjang diagnosis TB, dan pengobatan dengan OAT memberikan perbaikan bermakna.Kata kunci: lupus vulgaris, diseminata, OAT, ofloksasin

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Diagnostics and treatment of scrofuloderm

Gadzhimuradov

Alieva

Гунашева

et al. 2020

Tuberk. bolezni lëgk.

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ФГБОУ ВО «Дагестанский государственный медицинский университет» МЗ РФ, г. Махачкала, РФ 2 Андижанский государственный медицинский институт МЗ РУ, г. Андижан, Республика Узбекистан 3 ГБУ РД «РКВД», г. Махачкала, РФ Скрофулодерма-редкое проявление туберкулеза кожи. Приведено наблюдение случая вторичной скрофулодермы у мужчины 35 лет. Случай демонстрирует существенные и необратимые косметические дефекты скрофулодермы, а также важность своевременного применения методов эффективной диагностики туберкулеза (молекулярно-генетических, гистологических, мультисрезовой компьютерной томографии органов грудной клетки) и современных подходов к противотуберкулезной терапии, основанных на лекарственной чувствительности возбудителя.

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Cutaneous tuberculosis- a clinico-pathological study

Cited by 3 publications

References 0 publications

Histopathological Evaluation of Chronic Non Healing Ulcers of Skin in Patients Referred to Tertiary Care Hospital in Kashmir.

Histopathological Evaluation of Chronic Non Healing Ulcers of Skin in Patients Referred to Tertiary Care Hospital in Kashmir.

Lupus Vulgaris Dengan Lesi Diseminata

Diagnostics and treatment of scrofuloderm

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