Cutaneous true histiocytic malignancy: True histiocytic lymphoma

Malignant histiocytosis of the skin: a case report and review of the literature

“…Scrutiny of the dermatologic literature yields few cases of malignant histiocytosis presenting in the skin using restrictive criteria as defined by Pileri et al 1 (a malignant neoplasm of histiocytes, positive for one or more histiocytic markers but negative for accessory/dendritic cell markers). 1,6,13 Several cases in the past have also been diagnosed as such, but do not adhere to the latest criteria and/or lack the appropriate immunostaining techniques. 7,11,14,15 To the best of our knowledge, this is the first case reported that adheres to Pileri's criteria yet does not show evidence of systemic involvement.…”

“…7 Skin involvement is uncommon (10-15%), but is rarely the presenting symptom. [6][7][8][9][10][11][12][13] Skin lesions are typically erythematous, maculopapular and can progress to papular or nodular lesions, with purpura, scaling and/or ulceration. 7,9,11,12 The male to female ratio is 2-3.5 : 1.…”