Cutaneous transmissible venereal tumor without genital involvement in a prepubertal female dog

Abstract

An 11-month-old prepubertal crossbreed female dog was presented with multiple nodular lesions disseminated over the cervical, back, flank, and abdominal regions. The lesions were ulcerated and cauliflowerlike, or nodular and subcutaneous, measuring up to 13 cm in diameter. Cytologic preparations of one of the lesions revealed a uniform population of round to oval cells, with lightly basophilic cytoplasm that contained multiple distinct vacuoles. Frequent mitotic figures and occasional lymphocytes were also observed. The cytologic diagnosis was cutaneous transmissible venereal tumor (TVT) in a progressing growth phase. This was confirmed by histologic and immunohistochemical findings. Vaginal TVT was diagnosed later in the dog's mother. TVT is a contagious neoplasm of sexually mature dogs that usually is transmitted by coitus and affects the genital mucosa. To our knowledge, this is the first report of naturally occurring multicentric TVT in a prepubertal female dog and also is unique in its exclusively cutaneous (no mucosal) involvement. We speculate that transmission of neoplastic cells occurred during cohabitation and social/mothering behavior between the dogs. Despite the atypical clinical presentation, response to chemotherapy with vincristine was excellent, leading to complete regression of the neoplasm without relapse after 6 months.

Clinico-pathological study on metastatic form of canine Transmissible Veneral Tumour (TVT) and its therapeutic management

“…Impression smear prepared on 28 th day of post treatment shows regressing tumour cells and areas with populating neutrophils. Similar findings were also reported by Marcos et al, (2006) [5] and Gonzalez et al, (2000) [2] .…”

Multifocal metastatic cutaneous and mucosal transmissible venereal tumour in a female puppy

“…It is possible that the initial mild muzzle thickening noted by the owner was an early lesion. Pups may develop oral or tonsillar lesions associated with licking infected vaginal discharges of the dam (van Rensburg and Petrick 1980, Marcos and others 2006), which may account for the patient's young age of onset. A delayed latency period may also have been observed in this patient due to immunity in the dam (Moulton 1978).…”

Tumor Venéreo Transmisible Canino Extragenital: Estudio Retrospectivo De 11 Casos

“…Se indica que la afección de la cavidad nasal puede ser uni o bilateral, siendo la signología más frecuente la epistaxis del lado afectado (Ortega-Pacheco et al Park et al, 2006), fenómeno que se corrobora con los nueve casos de TVT nasal en estudio, donde este signo estuvo presente en todos los animales. Asimismo, ninguno de los caninos con TVT nasal presentó lesiones primarias en órganos genitales, de modo que se les considera como implantaciones primarias (Papazoglou et al, 2001;Marcos et al, 2006). La presentación anal es una de las ubicaciones menos frecuente de presentación extragenital, y usualmente sigue un patrón de implantación primaria debido al olfateo, estornudo o lamido de ejemplares afectados con TVT nasal u oral (Papazoglou et al, 2001).…”