Cutaneous toxicity of liquified methylamine gas

Abstract

The delayed‐type allergenicity of triforine (Saprol®), 1,4‐bis (2,2,2‐trichloro‐l‐formamidoethyl) piperazine, was studied. In a mass examination of chrysanthemum growers among whom triforine was commonly used, the highest rate of positive patch test reaction was seen to triforine (17%) among the 7 pesticides and chrysanthemum extracts tested. A higher prevalence rate of work‐related skin symptoms was seen in subjects with a positive patch test reaction to triforine (44%) than in those with negative reactions to all allergens tested (15%) (p < 0.05). 12 subjects (67%) with positive patch test reactions to triforine were also positive to dichlorvos (DDVP®), with a high × coefficient (0.65). The grading of guinea pig maximization test to triforine was grade IV (66%), defined as “strong”, Cross‐sensitization between triforine and dichlorvos was also shown. The present results confirm that triforine is capable of including delayed‐type allergy among chrysanthemum growers and of showing cross‐reactivity with dichlorvos.