Cutaneous T-Cell–Rich Lymphoid Infiltrates After SARS-CoV-2 Vaccination

Abstract

The most common skin reactions to mRNA-based vaccination against SARS-CoV-2 have included local and delayed injection site reactions and urticaria and have been more frequently associated with the Moderna vaccine vs the Pfizer/ BioNTech vaccine. 1 To our knowledge, cutaneous lymphoid reactions to COVID-19 vaccination have yet to be assessed in comprehensive vaccine studies.Methods | From March to November 21, in accordance with a Northwestern University institutional review boardapproved protocol, this retrospective case series included 6 cases of T-cell-rich cutaneous lymphoid infiltrates shortly after SARS-CoV-2 vaccination, 2 of which were recently described by some of our group. 2 Written informed consent was obtained. This study followed the reporting guideline for case series. R, version 2021.09.1, was used for statistical analyses.

Post-Transplant Lymphoproliferative Disorder, Monomorphic Type, in a Kidney Transplant Patient After Administration of Anti-Influenza Vaccine

“…6 These local pseudolymphomatous responses at the injection site have also been described with other types of vaccines, including vaccines against early summer meningoencephalitis, tetanus, hepatitis A and B, 7,8 and the anti-COVID vaccine. 9,10 Pseudolymphomatous responses have also been described after injections of allergens. 11…”

Painful Palmoplantar Lesions Following Vaccination: Answer

“…10 Indeed, 4 cases of LyP have been reported after the first dose of COVID-19 vaccination. 11,12 All cases except 1 were caused by the…”

“…10 Indeed, 4 cases of LyP have been reported after the first dose of COVID-19 vaccination. 11,12 All cases except 1 were caused by the BNT162b2 vaccine. It is worth noting that 3 of them, including ours, regardless of their histological type, exhibit an acral distribution.…”

Real‐world data on primary cutaneous lymphoproliferative disorders following SARS‐CoV‐2 vaccination: A multicentre experience from tertiary referral hospitals

“…Conversely, in a recent case series, low‐grade cutaneous lymphoid reactions after COVID‐19 vaccination have been observed. 7 Recurrence of pre‐existing complete remission PCLDs has also been described following COVID‐19 vaccine, with several case reported so far. 3 , 8 , 9 The overproduction and exhaustion of CD4+ and CD8+ lymphocytes, expressing CD30 after being triggered by the vaccine, might be held responsible for the disease recurrence.…”