Cutaneous T‐Cell Lymphoma With Sézary Syndrome in a Dog

Foster, Aiden P; Evans, Evan; Kerlin, Roy L.; Vail, David M.

doi:10.1111/j.1939-165x.1997.tb00735.x

Cited by 33 publications

(40 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4 In contrast, high tumor burden, advanced disease stage, and presence of Sézary syndrome were not identified as poor prognostic indicators in this study of canine ELSA, likely because of the lack of uniform staging performed in this retrospective study and the low number of cases in each prognostic category. For example, as Sézary syndrome is an infrequently reported finding with ELSA, 21 only 2 dogs presented with a lymphocytosis prompting review of blood smears and documentation of circulating malignant T cells. The number of dogs with Sézary syndrome likely was underestimated as a pathologist review of all blood smears was not consistently performed.…”

Section: Discussionmentioning

confidence: 99%

Response of Canine Cutaneous Epitheliotropic Lymphoma to Lomustine (CCNU): A Retrospective Study of 46 Cases (1999–2004)

Risbon¹,

Lorimier

Skorupski

et al. 2006

Veterinary Internal Medicne

View full text Add to dashboard Cite

Background: Epitheliotropic lymphoma (ELSA) is an uncommon cutaneous canine malignancy of T lymphocytes. A consensus regarding the therapeutic standard of care is lacking, warranting evaluation of chemotherapeutic agents traditionally employed against canine nodal lymphoma in the treatment of ELSA.Hypothesis: The purpose of this retrospective, multi-institutional study was to evaluate the efficacy of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in the treatment of ELSA.Animals: Forty-six dogs with adequate follow-up and treatment response information. Methods: All cases were diagnosed histopathologically. Immunohistochemisty (CD3, CD79a) was performed on 42/46 samples.Results: Presenting skin lesions included generalized scales (25/46), plaques or nodules (22/46), mucocutaneous lesions (14/ 46), and corneal involvement (1/46). Lymph node involvement and Sézary syndrome were documented in 7 and 2 dogs, respectively. The median number of CCNU treatments was 4 (range, 1-11), with a median starting dose of 60 mg/m 2 (range, 30-95). Of the 46 dogs, 15 achieved complete remission, 23 achieved partial remission, 5 had stable disease, and 3 had progressive disease, for an overall response rate of 83%. The median number of treatments to achieve a response was 1 (range, 1-6). The overall median duration of response was 94 days (range, 22-282). Sixteen dose reductions were required because of neutropenia (10/46), thrombocytopenia (1/46), anemia (1/46), increased liver enzyme activity (3/46), or unspecified reasons (1/46).Conclusions and Clinical Implications: Given the high response rate and well tolerated protocol, prospective studies are warranted to investigate the utility of CCNU alone or in multi-agent protocols for the treatment of ELSA.

show abstract

Section: Discussionmentioning

confidence: 99%

Response of Canine Cutaneous Epitheliotropic Lymphoma to Lomustine (CCNU): A Retrospective Study of 46 Cases (1999–2004)

Risbon¹,

Lorimier

Skorupski

et al. 2006

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…16,20 Cutaneous lymphoma with leukemia has occasionally been reported in dogs. 7,22 In cats, cutaneous lymphoproliferative diseases exhibit variable manifestations. There may be a benign 9 or malignant 4 behavior, lesions may be epitheliotropic 21,23 or restricted to the dermis, 4,13 and rarely there is association with leukemia.…”

Section: /Cd3mentioning

confidence: 99%

“…[5][6][7][8] In people, MF is the most common type of cutaneous T-cell lymphoma and accounts for more than 50% of all primary cutaneous lymphoma. 26 It is a proliferative disorder of CD4 show intraepithelial clustering of lymphocytes, known as Pautrier microabscess.…”

mentioning

confidence: 99%

Perforin Expression in Feline Epitheliotropic Cutaneous Lymphoma

2008

View full text Add to dashboard Cite

Abstract. Cutaneous lymphomas are uncommon in people and companion animals. The tumors can be broadly categorized into epitheliotropic and nonepitheliotropic forms, which appear to have different biological behaviors. The present case describes a feline cutaneous epitheliotropic lymphoma. Masses in a 9-year-old cat were first identified on the tail. The cat was treated with chemotherapy, but additional skin masses developed on the flank, face, and ears. Local radiation induced transient tumor regression, but eventual dissemination prompted euthanasia 13 months after initial tumor appearance. Granular lymphocytes were consistently detected on blood smears, and histologically, the tumor involved the skin and superficial subcutis. Tumor lymphocytes expressed cluster of differentiation 3 (CD3) and perforin molecules, suggestive of a cytotoxic phenotype. Location, histopathological features, and perforin expression were similar to a distinct entity in human medicine designated primary cutaneous, CD8-positive, epidermotropic, cytotoxic, T-cell lymphoma.

show abstract

“…The formation of distant metastases is described in dogs with mycosis fungoides and Sezary syndrome (Fontaine et al, 2009). Sezary syndrome is characterized by, as well as skin lesions, the presence of neoplastic cells with an atypical cerebriform appearance of the nucleus in peripheral blood (Sezary cells) (Thrall et al, 1994;Foster et al, 1997). In our case Sezary cells were not present.…”

Section: Discussionmentioning

confidence: 59%

“…The disease is also characterized by intensive pruritus (Thrall et al, 1984;Foster et al, 1997;Fontaine et al, 2009).…”

mentioning

confidence: 99%

Epitheliotropic cutaneous lymphoma (mycosis fungoides) with formation of nodal and distant metastases in a dog: a case report

Fictum¹,

Skoric²,

Segesova³

et al. 2009

Vet. Med. - Czech

View full text Add to dashboard Cite

The presented case describes an interesting manifestation of epitheliotropic cutaneous lymphoma with formation of nodal and distant metastases in an 8-year-old cocker spaniel. Cutaneous lesions included multiple hypotrichous to alopetic foci, scales, erythematous plaques and multiple cutaneous nodules, often with superficial ulceration. The lesions were present predominantly on the neck, thorax, abdomen and hind legs. Clinically, the dog showed lethargy and there was an inappetence and a mild dyspnoe. Subsequent findings were generalized lymphadenopathy, fever, pallor of mucous membranes and tachycardia. Smear impression of cutaneous nodules contained degenerated neutrophils with phagocytized cocci and macrophages. Cytological examination of nodules (FNA) showed a predominantly round cell population, with a compound of histiocytoid cells mixed with cells of inflammatory infiltration. Histopathological examination of the skin was performed. There was infiltrate of large neoplastic round cells in the superficial and deep dermis, morphologically resembling histiocytes. In some tissue sections the neoplastic infiltrate was present only in the superficial dermis, composed of medium-sized lymphocytes with hyperchromatic round, oval to indented nuclei 1.5 red cells in diameter and a small amount of eosinophilic cytoplasm. Focal exulceration, formation of Pautrier’s microabscesses in epidermis, and in some sections subepidermal and intraepidermal vesiculopustules and intraepidermal vesicles were present. Neoplastic infiltrate was CD3, CD18 and vimentin positive. Examination for CD79 and CD117 was negative. MHC II positivity was found only focally in cells of inflammatory infiltration in superficial dermis. Diagnosis of epitheliotropic cutaneous lymphoma (mycosis fungoides) was carried out. The response to the therapy of the disease was poor and the dog died two months after diagnosis. Necropsy revealed generalized lymphadenopathy, several white, fat-like nodules in heart muscle, lungs, esophagus and stomach, and mild hepatomegaly and splenomegaly. Multiple white disseminated foci were found in the spleen. Histopathological examination showed round cell, CD3 positive neoplastic infiltrate in heart, lungs, spleen, liver, lymph nodes, esophagus and stomach, morphologically corresponding with neoplastic infiltrate found in skin.

show abstract

Cutaneous T‐Cell Lymphoma With Sézary Syndrome in a Dog

Cited by 33 publications

References 15 publications

Response of Canine Cutaneous Epitheliotropic Lymphoma to Lomustine (CCNU): A Retrospective Study of 46 Cases (1999–2004)

Response of Canine Cutaneous Epitheliotropic Lymphoma to Lomustine (CCNU): A Retrospective Study of 46 Cases (1999–2004)

Perforin Expression in Feline Epitheliotropic Cutaneous Lymphoma

Epitheliotropic cutaneous lymphoma (mycosis fungoides) with formation of nodal and distant metastases in a dog: a case report

Contact Info

Product

Resources

About