Cutaneous T‐cell lymphoma—Focus on some problems, and some solutions

Abstract

Cutaneous lymphomas are a heterogeneous group of several distinct entities of lymphoproliferative diseases. The diagnosis of a cutaneous lymphoma is a challenge, and it is always the result of a careful analysis of several information's consisting of clinical history, clinical picture, histological and molecular analyses. For this reason, experts taking care of patients with a skin lymphoma need to know all the peculiar diagnostic elements very well, in order not to run into mistakes. In this article, we will focus the discussion on some issues as the skin biopsy (when and where). In addition, we will discuss the approach to the erythrodermic patient, whose differential diagnoses include mycosis fungoides, and Sézary syndrome, beside more frequent inflammatory conditions. Finally, we will address the issue of quality of life and the possible support of the suffering patient with a cutaneous lymphoma, well knowing that the current therapeutic possibilities are unfortunately limited.

Cantharidin overcomes IL-2Rα signaling-mediated vorinostat resistance in cutaneous T-cell lymphoma through reactive oxygen species

“…Cutaneous T-cell lymphoma (CTCL), a rare non-Hodgkin’s lymphoma derived from T cell, can be divided into the most common variants named mycosis fungoides and Sezary syndrome. 1 The latter is the erythrodermic and leukemic form of the disease. Although the majority of patients with early-stage CTCL have a normal life, those in advanced stages have a comprised survival and progress to more malignant disease, that is characterized by malignant T cells accumulating in the skin, blood and lymph nodes.…”