Cutaneous T-Cell and NK-Cell Lymphomas

Kinney, Marsha C.; Jones, Dan

doi:10.1309/mttm86ut1xfql7rv

Cited by 31 publications

References 126 publications

(125 reference statements)

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Lethal vascular leak syndrome after denileukin diftitox administration to a patient with cutaneous gamma/delta T‐cell lymphoma and occult cirrhosis

et al. 2008

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Denileukin diftitox (Ontak) is an immunotoxin used in the treatment of cutaneous T-cell lymphomas. Vascular leak syndrome is a known complication of this therapy, although the syndrome is most often self-limited. We report the case of a patient with cutaneous gamma/delta (cd) T-cell lymphoma and previous undiagnosed liver disease treated with denileukin diftitox. Just 4 days after initiating drug therapy, the patient developed profound vascular leak syndrome characterized by a rapid fall in his previously normal serum albumin to levels below the limit of detection. The patient then quickly deteriorated into rhabdomyolysis and eventual death. To our knowledge, this is the first report of a death directly related to denileukin diftitox therapy. The purpose of this case is to increase awareness and improve management of patients who are treated with denileukin diftitox with resulting vascular leak syndrome leading to hypoalbuminemia. Am. J. Hematol. 83:593-600, 2008. V

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Lethal vascular leak syndrome after denileukin diftitox administration to a patient with cutaneous gamma/delta T‐cell lymphoma and occult cirrhosis

et al. 2008

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Cutaneous T-cell Lymphomas

Chandra¹,

Oyarzo

Jones

2009

Neoplastic Hematopathology

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Abstract/Scope of Chapter T-cell malignancies presenting in the skin include mycosis fungoides, primary cutaneous anaplastic large cell lymphoma, and the related regressing lesion lymphomatoid papulosis as well as viral-associated adult T-cell leukemia/lymphoma. Rarer and more aggressive primary cutaneous lymphomas include extranodal natural killer cell/T-cell lymphoma, nasal type, subcutaneous panniculitits-like T-cell lymphoma, cutaneous gamma-delta T-cell lymphoma, and cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma. Systemic T-cell lymphomas that frequently involve the skin secondarily, such as angioimmunoblastic T-cell lymphoma, systemic anaplastic large cell lymphoma, and peripheral T-cell lymphoma, unspecified, are covered in Chap. 22.

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Cutaneous T-Cell Lymphomas: Mycosis Fungoides and Sézary Syndrome

Duvic¹

2013

Lymphoma

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Cutaneous T-Cell and NK-Cell Lymphomas

Cited by 31 publications

References 126 publications

Lethal vascular leak syndrome after denileukin diftitox administration to a patient with cutaneous gamma/delta T‐cell lymphoma and occult cirrhosis

Lethal vascular leak syndrome after denileukin diftitox administration to a patient with cutaneous gamma/delta T‐cell lymphoma and occult cirrhosis

Cutaneous T-cell Lymphomas

Cutaneous T-Cell Lymphomas: Mycosis Fungoides and Sézary Syndrome

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